Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma

(2020) Nicholas Frazzette et al.   npj Precision Oncology

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

(2020) Satotaka Omori et al.   Cell Metabolism

Cellular Senescence

(2020) Yongxin Li et al.   HYPERTENSION

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

(2020) Antonio Marra et al.   npj Breast Cancer

EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures

(2020) Suhas V. Vasaikar et al.   BRITISH JOURNAL OF CANCER

Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors

(2020) Lise Lefèvre et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Senescent cells and macrophages: key players for regeneration?

(2020) Sonia S. Elder et al.   Open Biology

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species

(2019) Kurt A. Zimmerman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal-Tubule Epithelial Cell Nomenclature for Single-Cell RNA-Sequencing Studies

(2019) Lihe Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

(2019) Seo Rin Kim et al.   Translational Research

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

(2019) Adrian Santelli et al.   Journal of the American Heart Association

Spatiotemporal immune zonation of the human kidney

(2019) Benjamin J. Stewart et al.   SCIENCE

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

(2019) Fei Li et al.   Cancer Discovery

Using single-cell technologies to map the human immune system — implications for nephrology

(2019) Benjamin J. Stewart et al.   Nature Reviews Nephrology

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production

(2018) Daigo Sawaki et al.   CIRCULATION

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

(2018) Nikos Karaiskos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Renal scattered tubular-like cells confer protective effects in the stenotic murine kidney mediated by release of extracellular vesicles

(2018) Xiangyu Zou et al.   Scientific Reports

Aging, Cell Senescence, and Chronic Disease

(2018) Tamara Tchkonia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

(2018) Matthew D. Young et al.   SCIENCE

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney

(2018) Amrutesh S. Puranik et al.   Scientific Reports

Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels

(2018) In O Sun et al.   HYPERTENSION

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

(2018) Trygve E. Bakken et al.   PLoS One

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq

(2017) Lihe Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive Assessment of Renal Fibrosis with Magnetization Transfer MR Imaging: Validation and Evaluation in Murine Renal Artery Stenosis

(2017) Kai Jiang et al.   RADIOLOGY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth

(2017) Adriana P. Jiménez et al.   Oncotarget

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Low-Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

(2016) X. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Open-source ImmGen: mononuclear phagocytes

(2016)   NATURE IMMUNOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Long-Term Side Effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

(2016) Lauren Caldemeyer et al.   Current Hematologic Malignancy Reports

Atherosclerotic Renal Artery Stenosis: Current Status

(2015) Soon Hyo Kwon et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Global Deletion of Ankrd1 Results in a Wound-Healing Phenotype Associated with Dermal Fibroblast Dysfunction

(2015) Susan E. Samaras et al.   AMERICAN JOURNAL OF PATHOLOGY

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity

(2015) Takahiko Toyonaga et al.   PLoS One

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

(2014) Birgit Berkenkamp et al.   PLoS One

Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis

(2013) Alfonso Eirin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury

(2013) Meghan E. Clements et al.   PLoS One

Inflammatory and injury signals released from the post-stenotic human kidney

(2012) Alfonso Eirin et al.   EUROPEAN HEART JOURNAL

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Small Leucine-Rich Proteoglycans in Kidney Disease

(2011) L. Schaefer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apoptosis and acute kidney injury

(2011) Andrea Havasi et al.   KIDNEY INTERNATIONAL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Mechanisms of Tissue Injury in Renal Artery Stenosis: Ischemia and Beyond

(2009) Lilach O. Lerman et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Osteopontin functions as an opsonin and facilitates phagocytosis by macrophages of hydroxyapatite-coated microspheres: Implications for bone wound healing

(2008) Claudio E. Pedraza et al.   BONE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

VEGF Inhibition and Renal Thrombotic Microangiopathy

(2008) Vera Eremina et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival

(2008) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA