Review
Biology
Ewa Kwiatkowska, Sebastian Kwiatkowski, Violetta Dziedziejko, Izabela Tomasiewicz, Leszek Domanski
Summary: Acute kidney injury (AKI) can occur due to reduced renal perfusion, with the kidneys being susceptible to ischemia because of the anatomical microcirculation around the renal tubules. Impaired blood flow causes damage to the endothelium and thrombosis, leading to the destruction of small vessels. This peritubular rarefaction is believed to be the main cause of irreversible changes in the damaged kidney and the development of chronic kidney disease. This article discusses the structure of renal microcirculation, its regulation, and the mechanisms of acute ischemic damage, with a focus on preventing it through the inhibition of the renin-angiotensin-aldosterone system.
Article
Chemistry, Multidisciplinary
Ruo-bing Guo, Yin-feng Dong, Zhi Yin, Zhen-yu Cai, Jin Yang, Juan Ji, Yu-qin Sun, Xin-xin Huang, Teng-fei Xue, Hong Cheng, Xi-qiao Zhou, Xiu-lan Sun
Summary: The study demonstrates that iptakalim can significantly promote recovery of cerebral blood flow after cerebral ischemia and reperfusion, inhibit pericytes contraction, improve cerebral microcirculation, and reduce the number of obstructed capillaries. Furthermore, iptakalim treatment promotes K-ATP channel opening, leading to decreased calcium influx and ET-1 release.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, General & Internal
Patrick Weninger, Christoph Thallinger, Manuel Chytilek, Yannis Hanel, Caterina Steffel, Ramin Karimi, Xaver Feichtinger
Summary: The purpose of this study was to investigate the effects of repetitive ESWT on the recovery time, clinical results, and MRI results after ACL reconstruction. The results showed that patients in the ESWT group had a shorter recovery time, better clinical scores, and improved graft maturation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Su Jeong Wang, Chan-Hyuk Lee, Hyun Goo Kang, Ko Woon Kim, Minjoo Kim, Hwan-Jeong Jeong, Byoung-Soo Shin
Summary: This study analyzed the peripheral vasoreactivity of patients with acute ischemic stroke and hemiplegia using a modified Raynaud scan. The results showed that affected limb edema and anterior circulation were associated with impaired vasoreactivity, which may inform treatment for stroke patients with hemiparesis.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Katerina Apelt, Roel Bijkerk, Franck Lebrin, Ton J. Rabelink
Summary: Renal microvascular rarefaction is crucial in progressive kidney disease, yet there is a lack of non-invasive imaging modalities to monitor changes in renal microvasculature in patients. Studying and evaluating renal disease based on in vivo readouts with a resolution up to capillary level may lead to a paradigm shift in nephrology.
Article
Biochemistry & Molecular Biology
Jason S. Holsapple, Ben Cooper, Susan H. Berry, Aleksandra Staniszewska, Bruce M. Dickson, Julie A. Taylor, Paul Bachoo, Heather M. Wilson
Summary: Extracorporeal Shock Wave Therapy (ESWT) plays a crucial role in promoting wound healing by enhancing angiogenesis, reducing macrophage numbers, and increasing macrophage activation. Shockwave treatment boosts the uptake of apoptotic cells by macrophages, promotes healing-associated cytokine and growth factor gene expressions, and modulates macrophage morphology through mechanotransduction pathways, contributing to wound resolution. These findings reveal shockwaves as important regulators of macrophage functions linked with wound healing, representing an underappreciated role of clinically applied shockwaves that could be utilized for other macrophage-mediated disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Daun Jeong, Jin Hyuck Lee, Gyu Bin Lee, Ki Hun Shin, Jangsun Hwang, Se Youn Jang, Jin Yoo, Woo Young Jang
Summary: Extracorporeal shockwave therapy (ESWT) can promote microcirculation in patients with Wagner grades I to II diabetic foot ulcers. However, this effect requires at least 2 weeks or more than 6 sessions of treatment. Further studies with larger clinical groups and an extended period are needed for better comparison.
Review
Cardiac & Cardiovascular Systems
Michael Graber, Felix Naegele, Jakob Hirsch, Leo Poelzl, Victor Schweiger, Sophia Lechner, Michael Grimm, John P. Cooke, Can Gollmann-Tepekoeylue, Johannes Holfeld
Summary: Shockwave therapy (SWT) has shown potential as a regenerative approach in the field of regenerative medicine. It can induce tissue regeneration through growth factor release, modulation of inflammatory response, and angiogenesis. Clinical studies have suggested that SWT may improve angina, exercise tolerance, and hemodynamics in patients with myocardial ischemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Alexander Sogorski, Maryna Dostibegian, Marcus Lehnhardt, Christoph Wallner, Johannes M. Wagner, Mehran Dadras, Maxi von Glinski, Jonas Kolbenschlag, Bjoern Behr
Summary: The study demonstrates that remote ischemic conditioning can improve blood flow and oxygen saturation of free flaps, enhancing perfusion, preventing microcirculatory disorders, and reducing the risk of tissue necrosis. The effects on different perfusion zones last for at least 4 hours.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Medicine, General & Internal
Yin-Chin Wang, Ming-Jiuh Wang, Chih-Yuan Lee, Chien-Chia Chen, Ching-Tang Chiu, Anne Chao, Wing-Sum Chan, Meng-Kun Tsai, Yu-Chang Yeh
Summary: This study investigated the effect of dexmedetomidine on postoperative renal function and sublingual microcirculation in kidney transplant recipients. The results showed that early postoperative renal function was better in kidney transplant recipients receiving dexmedetomidine infusion, but total vessel density was not significantly different between the intervention and control groups.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Walter Vena, Liborio Vaccalluzzo, Sandro La Vignera, Emanuela Morenghi, Cristina D'Agostino, Anna Perri, Bruno Giammusso, Andrea G. Lania, Antonio Aversa, Alessandro Pizzocaro
Summary: This study aimed to evaluate the improvement of penile vascular flows after LISWT treatment in patients with ED. The results showed that LISWT improved erectile hardness and satisfaction rates among patients with ED.
MINERVA ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Yun-Nan Lin, Keng-Fan Liu, Chun-Ting Wang, Savitha Ramachandran, Ching-Jen Wang, Yur-Ren Kuo
Summary: This study demonstrated that both ESWT and BIO treatment significantly promoted diabetic wound healing and were associated with the GSK-3 beta-mediated Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Nataliya G. Kolosova, Egor Y. Plotnikov, Dmitry B. Zorov
Summary: Kidney diseases are common among elderly people due to age-related changes in renal tissue. The lack of targeted pharmacotherapies for acute kidney injury (AKI) results in high mortality rates. This study investigated the protective effects of calorie restriction (CR) on ischemic AKI in OXYS rats and found that CR provided significant nephroprotection. Improvements in mitochondrial functioning may be one of the mechanisms for the beneficial effects of CR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mohammad Rizki Akbar, Dwi Laksono Adiputro, Badai Bhatara Tiksnadi, Erwin Affandi Soeriadi, Melawati Hasan, Fauzan Muttaqien, Pradana Pratomo Raharjo, Eliza Nurazizah, Najmi Fauzan Tarsidin
Summary: This study reports clinical cases of patients with CABG-SAP undergoing ESMR therapy, and finds that this treatment can improve ischemic response, functional capacity, and physical component of quality of life.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Henna Korpela, Olli-Pekka Hatinen, Tiina Nieminen, Rahul Mallick, Pyry Toivanen, Jonna Airaksinen, Kaisa Valli, Mikko Hakulinen, Pekka Poutiainen, Jussi Nurro, Seppo Yla-Herttuala
Summary: The study found that the unprocessed VEGF-B isoform can function as an effective angiogenic growth factor, while only the VEGF-B186 C-terminal fragment is associated with arrhythmias.