Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity

Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis

(2020) Fabio Alessandro Facchini et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

(2020) Martin C. Moncrieffe et al.   STRUCTURE

Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview

(2020) Alessio Romerio et al.   Frontiers in Immunology

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

(2020) Andrea Iannucci et al.   PLoS Pathogens

Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

(2018) Fabio A. Facchini et al.   JOURNAL OF MEDICINAL CHEMISTRY

TLR4-based immunotherapeutics in cancer: a review of the achievements and shortcomings

(2018) Maryam A. Shetab Boushehri et al.   MOLECULAR PHARMACEUTICS

Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

(2017) Dieke van Dinther et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

(2017) Laure Perrin-Cocon et al.   Scientific Reports

The science of vaccine adjuvants: advances in TLR4 ligand adjuvants

(2016) Steven G Reed et al.   CURRENT OPINION IN IMMUNOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

TLR4 agonists as vaccine adjuvants: a chemist’s perspective

(2013) David A Johnson   Expert Review of Vaccines

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

TRIF Is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expansion

(2013) Siva K. Gandhapudi et al.   PLoS One

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

(2013) M. Vono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses

(2012) J. Garaude et al.   Science Translational Medicine

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics

(2008) David Johnson   CURRENT TOPICS IN MEDICINAL CHEMISTRY