Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

HPV18 Persistence Impairs Basal and DNA Ligand–Mediated IFN-β and IFN-λ1Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling

(2018) Silvia Albertini et al.   JOURNAL OF IMMUNOLOGY

The effects of CD14 and IL-27 on induction of endotoxin tolerance in human monocytes and macrophages

(2018) Carlene Petes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Lipopolysaccharide Detection across the Kingdoms of Life

(2017) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases

(2016) Divaker Choubey et al.   AGEING RESEARCH REVIEWS

Distinct Anti-IFI16 and Anti-GP2 Antibodies in Inflammatory Bowel Disease and Their Variation with Infliximab Therapy

(2016) Valeria Caneparo et al.   INFLAMMATORY BOWEL DISEASES

The Role of Lipopolysaccharide Structure in Monocyte Activation and Cytokine Secretion

(2016) Rebecca E. Plevin et al.   SHOCK

Association of Antibodies to Interferon-Inducible Protein-16 With Markers of More Severe Disease in Primary Sjögren's Syndrome

(2016) Alan N. Baer et al.   ARTHRITIS CARE & RESEARCH

Circulating Interferon-Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis

(2016) Alessia Alunno et al.   ARTHRITIS CARE & RESEARCH

NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis

(2016) Mari H. Tervaniemi et al.   Scientific Reports

Up-regulation of Interferon-inducible protein 16 contributes to psoriasis by modulating chemokine production in keratinocytes

(2016) Tianyu Cao et al.   Scientific Reports

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

(2015) Wiebe Vanhove et al.   INFLAMMATORY BOWEL DISEASES

The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation

(2015) Mandar Bawadekar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

(2015) Irene Lo Cigno et al.   JOURNAL OF VIROLOGY

Interferon gamma-inducible protein 16 in primary Sjögren’s syndrome: a novel player in disease pathogenesis?

(2015) Alessia Alunno et al.   ARTHRITIS RESEARCH & THERAPY

New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16

(2015) Xiangmin Ni et al.   Journal of Molecular Cell Biology

Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection

(2015) Muhammad Ayaz Anwar et al.   Scientific Reports

IFI16: At the interphase between innate DNA sensing and genome regulation

(2014) Martin R. Jakobsen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA

(2014) S. Chiliveru et al.   JOURNAL OF IMMUNOLOGY

Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage

(2014) V. Dell'Oste et al.   JOURNAL OF VIROLOGY

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

(2013) V. V. Singh et al.   JOURNAL OF VIROLOGY

Anti-IFI16 antibodies and their relation to disease characteristics in systemic lupus erythematosus

(2013) V Caneparo et al.   LUPUS

Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

(2013) Francesca Gugliesi et al.   PLoS One

Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A

(2013) Carolyn R. Casella et al.   PLoS One

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

(2010) S. Costa et al.   BRITISH JOURNAL OF DERMATOLOGY

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

(2010) Melania Manco et al.   ENDOCRINE REVIEWS

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Evaluation of a Whole-Blood Cytokine Release Assay for Use in Measuring Endotoxin Activity of Group B Neisseria meningitidis Vaccines Made from Lipid A Acylation Mutants

(2009) M. B. Stoddard et al.   Clinical and Vaccine Immunology

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

Role of IFI16 in DNA damage and checkpoint

(2007) Mutsuko Ouchi   Frontiers in Bioscience-Landmark