Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling

Porphyromonas gingivalis Promotes Immunoevasion of Oral Cancer by Protecting Cancer from Macrophage Attack

(2020) Shiyu Liu et al.   JOURNAL OF IMMUNOLOGY

Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism

(2019) Yannick Degboé et al.   Frontiers in Immunology

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis

(2019) Bo Li et al.   Aging-US

Dysregulation of Akt-FOXO1 pathway leads to dysfunction of regulatory T cells in psoriasis patients

(2019) Bing Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of macrophage polarization in periodontal disease

(2019) Carlos Garaicoa‐Pazmino et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

(2019) Siyuan Chen et al.   Cellular & Molecular Immunology

Serum- and glucocorticoid-inducible kinase 1 is essential for osteoclastogenesis and promotes breast cancer bone metastasis

(2019) Zheng Zhang et al.   MOLECULAR CANCER THERAPEUTICS

The cytokine network involved in the host immune response to periodontitis

(2019) Weiyi Pan et al.   International Journal of Oral Science

MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway

(2019) Feng Liu et al.   Stem Cell Research & Therapy

Mucosal Immunity and the FOXO1 Transcription Factors

(2019) Dana T. Graves et al.   Frontiers in Immunology

The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation

(2018) Wenqiang Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models

(2018) Z. Zhuang et al.   JOURNAL OF DENTAL RESEARCH

Macrophage polarization in human gingival tissue in response to periodontal disease

(2018) Li‐Na Zhou et al.   ORAL DISEASES

Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis

(2017) Wenyu Fu et al.   FASEB JOURNAL

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human

(2017) Brice Nativel et al.   Scientific Reports

Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: a meta-analysis

(2016) Amanda F. Stadler et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Molecular control of activation and priming in macrophages

(2016) Christopher K Glass et al.   NATURE IMMUNOLOGY

Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer

(2016) Shegan Gao et al.   Infectious Agents and Cancer

Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging

(2016) Jeffrey L. Ebersole et al.   Frontiers in Immunology

Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer’s disease

(2016) Ingar Olsen et al.   Journal of Oral Microbiology

Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases

(2016) Ingar Olsen et al.   Journal of Oral Microbiology

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

(2016) Roselind S. Lam et al.   PLoS One

Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure

(2015) Huaxin Zhou et al.   FASEB JOURNAL

Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues

(2015) O. A. Gonzalez et al.   IMMUNOLOGICAL INVESTIGATIONS

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

(2015) Nicholas S. Kirkby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular features of macrophage activation

(2015) Joachim L. Schultze et al.   SEMINARS IN IMMUNOLOGY

The Many Alternative Faces of Macrophage Activation

(2015) David A. Hume   Frontiers in Immunology

Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR)

(2014) Hung Caohuy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Pulmonary Lipopolysaccharide Tolerance Decreases TNF-  without Reducing Neutrophil Recruitment

(2014) S. Natarajan et al.   JOURNAL OF IMMUNOLOGY

IFN-  Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3- 

(2014) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages

(2014) J. P. Luyendyk et al.   JOURNAL OF IMMUNOLOGY

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

(2014) Emily B Heikamp et al.   NATURE IMMUNOLOGY

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Inflammatory and immune pathways in the pathogenesis of periodontal disease

(2013) Ali Cekici et al.   PERIODONTOLOGY 2000

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II–Induced Inflammation and Cardiac Fibrosis

(2012) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency

(2011) Teresa F. Ackermann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1

(2011) Emelie Wallerstedt et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Exploring the oral bacterial flora: current status and future directions

(2009) NB Parahitiyawa et al.   ORAL DISEASES