BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
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Title
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 11, Pages -
Publisher
Rockefeller University Press
Online
2021-09-24
DOI
10.1084/jem.20201656
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- (2021) Alexander N. R. Weber Frontiers in Cell and Developmental Biology
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- (2020) Mark Roschewski et al. Science Immunology
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- (2020) Venkat Giri Magupalli et al. SCIENCE
- X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure
- (2020) Caroline E. O'Riordan et al. Frontiers in Immunology
- The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice
- (2020) Maximilian Franke et al. BRAIN BEHAVIOR AND IMMUNITY
- Recent insights into the regulatory networks of NLRP3 inflammasome activation
- (2020) Alexander N. R. Weber et al. JOURNAL OF CELL SCIENCE
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- (2019) Ana Tapia-Abellán et al. Nature Chemical Biology
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- (2019) Humayun Sharif et al. NATURE
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- (2019) Caroline E. O'Riordan et al. Frontiers in Immunology
- Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming
- (2018) Jack P. Green et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- Regulation of NLRP3 Inflammasome by Phosphorylation
- (2018) Nan Song et al. Frontiers in Immunology
- Bruton tyrosine kinase inhibition: Clinical relevance beyond B cells
- (2017) Balaji Banoth et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase
- (2017) Xiao Liu et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Protein kinase D at the Golgi controls NLRP3 inflammasome activation
- (2017) Zhirong Zhang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity
- (2017) Alexander N. R. Weber et al. Frontiers in Immunology
- NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
- (2016) Marianne R. Spalinger et al. JOURNAL OF CLINICAL INVESTIGATION
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- The Inflammasomes and Autoinflammatory Syndromes
- (2015) Lori Broderick et al. Annual Review of Pathology-Mechanisms of Disease
- A frequent hypofunctionalIRAK2variant is associated with reduced spontaneous hepatitis C virus clearance
- (2015) Hui Wang et al. HEPATOLOGY
- A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
- (2015) Jonathan L. Schmid-Burgk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury
- (2015) Minako Ito et al. Nature Communications
- PyTMs: a useful PyMOL plugin for modeling common post-translational modifications
- (2014) Andreas Warnecke et al. BMC BIOINFORMATICS
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
- (2013) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Function and dysfunction of the PI system in membrane trafficking
- (2008) Mariella Vicinanza et al. EMBO JOURNAL
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- PBEQ-Solver for online visualization of electrostatic potential of biomolecules
- (2008) Sunhwan Jo et al. NUCLEIC ACIDS RESEARCH
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