FcRn expression in cancer: Mechanistic basis and therapeutic opportunities
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
FcRn expression in cancer: Mechanistic basis and therapeutic opportunities
Authors
Keywords
Neonatal Fc Receptor, Targeted cancer therapy, Tumour metabolism, Albumin-drug designs, Antibody-drug designs, Cancer immunotherapy
Journal
JOURNAL OF CONTROLLED RELEASE
Volume 337, Issue -, Pages 248-257
Publisher
Elsevier BV
Online
2021-07-08
DOI
10.1016/j.jconrel.2021.07.007
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression
- (2021) Aamir Ali Khan et al. CANCER AND METASTASIS REVIEWS
- Metabolism of Amino Acids in Cancer
- (2021) Zhen Wei et al. Frontiers in Cell and Developmental Biology
- Unlocking the potential of antibody–drug conjugates for cancer therapy
- (2021) Joshua Z. Drago et al. Nature Reviews Clinical Oncology
- Targeted drug delivery strategies for precision medicines
- (2021) Mandana T. Manzari et al. Nature Reviews Materials
- Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
- (2021) Ole A. Mandrup et al. Communications Biology
- FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs
- (2020) Maja Thim Larsen et al. JOURNAL OF CONTROLLED RELEASE
- Exploiting the folate receptor α in oncology
- (2020) Mariana Scaranti et al. Nature Reviews Clinical Oncology
- Albumin-based drug designs for pharmacokinetic modulation
- (2020) Diego Pilati et al. Expert Opinion on Drug Metabolism & Toxicology
- The Latest Battles Between EGFR Monoclonal Antibodies and Resistant Tumor Cells
- (2020) Wen-Qi Cai et al. Frontiers in Oncology
- The tumor microenvironment
- (2020) Nicole M. Anderson et al. CURRENT BIOLOGY
- Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
- (2020) Christopher R Brown et al. NUCLEIC ACIDS RESEARCH
- Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date
- (2019) Lee D Cranmer OncoTargets and Therapy
- KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs
- (2019) Huiqin Liu et al. JOURNAL OF CONTROLLED RELEASE
- Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
- (2019) Dilip K. Challa et al. mAbs
- Determinants of nutrient limitation in cancer
- (2019) Mark R. Sullivan et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment
- (2019) Golnaz Sadeghnezhad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Acidic Tumor Microenvironment as a Driver of Cancer
- (2019) Ebbe Boedtkjer et al. Annual Review of Physiology
- Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia
- (2019) Adrian C. Newland et al. AMERICAN JOURNAL OF HEMATOLOGY
- Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns
- (2018) Natalia A. Lozano et al. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies
- (2018) Kasper Mølgaard et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer
- (2018) Xiaofei Wang et al. MOLECULAR PHARMACEUTICS
- Superior Therapeutic Efficacy of Nanoparticle Albumin Bound Paclitaxel Over Cremophor-Bound Paclitaxel in Experimental Esophageal Adenocarcinoma
- (2018) Md Sazzad Hassan et al. Translational Oncology
- Progress and challenges towards targeted delivery of cancer therapeutics
- (2018) Daniel Rosenblum et al. Nature Communications
- Cancer-associated cachexia
- (2018) Vickie E. Baracos et al. Nature Reviews Disease Primers
- Harnessing albumin as a carrier for cancer therapies
- (2018) Ella N. Hoogenboezem et al. ADVANCED DRUG DELIVERY REVIEWS
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy
- (2018) Guillaume Compain et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment
- (2018) Diana Cadena Castaneda et al. Frontiers in Immunology
- M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study
- (2018) Leona E. Ling et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Hypoalbuminemia: Pathogenesis and Clinical Significance
- (2018) Peter B. Soeters et al. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
- Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy
- (2017) Nicolas Joubert et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin
- (2017) Esben G. W. Schmidt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome–Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter Study
- (2017) Giovanni Martinelli et al. JOURNAL OF CLINICAL ONCOLOGY
- Distribution of FcRn Across Species and Tissues
- (2017) Sari Latvala et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding
- (2017) Julie Schmøkel et al. NANOTECHNOLOGY
- Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
- (2017) Michal Pyzik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
- (2017) Jessica B. Spinelli et al. SCIENCE
- Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy
- (2017) Christian Kellner et al. TRANSFUSION MEDICINE AND HEMOTHERAPY
- Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers
- (2017) Brigitte Renoux et al. Chemical Science
- Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors
- (2017) Katerina T. Xenaki et al. Frontiers in Immunology
- KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma
- (2016) Lei Shi et al. BMC CANCER
- Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
- (2016) De Huang et al. CELL RESEARCH
- Nanotransporters for drug delivery
- (2016) Tessa Lühmann et al. CURRENT OPINION IN BIOTECHNOLOGY
- Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment
- (2016) Guowei Gu et al. CURRENT OPINION IN PHARMACOLOGY
- Key determinants of energy expenditure in cancer and implications for clinical practice
- (2016) S A Purcell et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Optimizing initial chemotherapy for metastatic pancreatic cancer
- (2016) Kalyan C Mantripragada et al. Future Oncology
- Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs
- (2016) Dorthe Viuff et al. JOURNAL OF CONTROLLED RELEASE
- Tasquinimod treatment for prostate cancer
- (2016) Vicki Brower LANCET ONCOLOGY
- Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
- (2016) Shawn M Davidson et al. NATURE MEDICINE
- Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
- (2016) Tilman Schlothauer et al. PROTEIN ENGINEERING DESIGN & SELECTION
- The Highly Evolvable Antibody Fc Domain
- (2016) Hye In Park et al. TRENDS IN BIOTECHNOLOGY
- Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis
- (2016) Emilie Dalloneau et al. Oncotarget
- Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption
- (2016) Rafal Swiercz et al. Oncotarget
- A Phase II Study of Weekly Paclitaxel Plus Gemcitabine as a Second-Line Therapy in Patients with Metastatic or Recurrent Small Cell Lung Cancer
- (2016) Tak Yun et al. Cancer Research and Treatment
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
- (2015) Zachary T. Schug et al. CANCER CELL
- Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
- (2015) J. J. Kamphorst et al. CANCER RESEARCH
- The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
- (2015) Wilhelm Palm et al. CELL
- Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting
- (2015) Saskia Meyer et al. mAbs
- Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants
- (2015) Steffan S. Petersen et al. MOLECULAR PHARMACEUTICS
- Localization of the human neonatal Fc receptor (FcRn) in human nasal epithelium
- (2015) Sara Heidl et al. PROTOPLASMA
- Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment
- (2015) John T. Isaacs et al. Oncotarget
- Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms
- (2014) Vaheh Oganesyan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Acidity Generated by the Tumor Microenvironment Drives Local Invasion
- (2013) V. Estrella et al. CANCER RESEARCH
- Long-term Survival and Biomarker Correlates of Tasquinimod Efficacy in a Multicenter Randomized Study of Men with Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer
- (2013) A. J. Armstrong et al. CLINICAL CANCER RESEARCH
- Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer
- (2013) Kristi Baker et al. IMMUNITY
- Cancer cachexia—pathophysiology and management
- (2013) Hajime Suzuki et al. JOURNAL OF GASTROENTEROLOGY
- Albumin Is Recycled from the Primary Urine by Tubular Transcytosis
- (2013) V. Tenten et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
- (2013) Cosimo Commisso et al. NATURE
- Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis
- (2013) Pamela J. Hornby et al. PHARMACEUTICAL RESEARCH
- Transepithelial Transport of Fc-Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery
- (2013) E. M. Pridgen et al. Science Translational Medicine
- Developing an antibody-binding protein cage as a molecular recognition drug modular nanoplatform
- (2012) Hyo Jin Kang et al. BIOMATERIALS
- Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions
- (2012) J. T. Sockolosky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
- (2012) Jan Terje Andersen et al. Nature Communications
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Phase II Randomized, Double-Blind, Placebo-Controlled Study of Tasquinimod in Men With Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer
- (2011) Roberto Pili et al. JOURNAL OF CLINICAL ONCOLOGY
- Fc-mediated transport of nanoparticles across airway epithelial cell layers
- (2011) Driton Vllasaliu et al. JOURNAL OF CONTROLLED RELEASE
- Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells
- (2011) K. Baker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection
- (2011) Z. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced antibody half-life improves in vivo activity
- (2010) Jonathan Zalevsky et al. NATURE BIOTECHNOLOGY
- Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
- (2009) Héctor Pérez Montoyo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Cancer Cell Metabolism: Warburg and Beyond
- (2008) Peggy P. Hsu et al. CELL
- Dependence of antibody-mediated presentation of antigen on FcRn
- (2008) S.-W. Qiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides
- (2007) Ulrik L. Rahbek et al. JOURNAL OF GENE MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started