An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression
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Title
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression
Authors
Keywords
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Journal
CANCER AND METASTASIS REVIEWS
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-10
DOI
10.1007/s10555-020-09952-0
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Note: Only part of the references are listed.- Three hypomethylated genes were associated with poor overall survival in pancreatic cancer patients
- (2019) Huiming Chen et al. Aging-US
- High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma
- (2019) Maria Cristina Curia et al. BMC CANCER
- Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood
- (2019) Maryam A. L. Eissa et al. Clinical Epigenetics
- Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
- (2019) Min-Wu Chao et al. Clinical Epigenetics
- Anti-tumor effect and mechanistic study of elemene on pancreatic carcinoma
- (2019) Jin Long et al. BMC Complementary and Alternative Medicine
- Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells
- (2019) Paul Dent et al. ONCOGENE
- Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells
- (2019) Christophe Glorieux et al. Cancer Communications
- Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 – NFκB crosstalk
- (2019) Caroline R. Delma et al. PHYTOCHEMISTRY
- Emerging trends in the immunotherapy of pancreatic cancer
- (2018) Kasturi Banerjee et al. CANCER LETTERS
- SMAD4Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy
- (2018) Feng Wang et al. CLINICAL CANCER RESEARCH
- Epigenetics and MicroRNAs in Cancer
- (2018) Alice Ramassone et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans
- (2018) Mami Takahashi et al. CANCER SCIENCE
- Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
- (2018) Giovanna Butera et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features
- (2018) Francesco Puleo et al. GASTROENTEROLOGY
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The role of stromal cancer-associated fibroblasts in pancreatic cancer
- (2017) Dagny von Ahrens et al. Journal of Hematology & Oncology
- Tumor Mutational Burden and Response Rate to PD-1 Inhibition
- (2017) Mark Yarchoan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer
- (2017) Hideyuki Hayashi et al. PANCREAS
- Biology of pancreatic stellate cells—more than just pancreatic cancer
- (2017) Pawel E. Ferdek et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- DNA methylation markers for diagnosis and prognosis of common cancers
- (2017) Xiaoke Hao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma
- (2017) Ingunn M. Stromnes et al. Cancer Immunology Research
- Association between alcohol intake and the risk of pancreatic cancer: a dose–response meta-analysis of cohort studies
- (2016) Ye-Tao Wang et al. BMC CANCER
- Key role of pancreatic stellate cells in pancreatic cancer
- (2016) Srinivasa P. Pothula et al. CANCER LETTERS
- Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
- (2016) Sebastian Moran et al. LANCET ONCOLOGY
- Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
- (2016) Hanane Laklai et al. NATURE MEDICINE
- Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
- (2016) Andrew P. Feinberg et al. NATURE REVIEWS GENETICS
- Targeting the cancer epigenome for therapy
- (2016) Peter A. Jones et al. NATURE REVIEWS GENETICS
- The molecular hallmarks of epigenetic control
- (2016) C. David Allis et al. NATURE REVIEWS GENETICS
- Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling
- (2016) J Li et al. ONCOGENE
- Epigenetic Determinants of Cancer
- (2016) Stephen B. Baylin et al. Cold Spring Harbor Perspectives in Biology
- Clinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas: a systematic review and meta-analysis
- (2016) Jin-Dao Wang et al. Oncotarget
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents
- (2015) Kai Xue et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
- (2015) Stefano Ugel et al. JOURNAL OF CLINICAL INVESTIGATION
- Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
- (2015) Richard A Moffitt et al. NATURE GENETICS
- SMAD4 Expression Predicts Local Spread and Treatment Failure in Resected Pancreatic Cancer
- (2015) Suguru Yamada et al. PANCREAS
- Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
- (2015) Manuel Hidalgo et al. PANCREATOLOGY
- Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies
- (2015) Andrea Teague et al. Therapeutic Advances in Medical Oncology
- Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
- (2015) Michael J. Thompson et al. PLoS One
- Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer
- (2015) Bo Tang et al. Scientific Reports
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- CDK4/6 and IGF1 Receptor Inhibitors Synergize to Suppress the Growth of p16INK4A-Deficient Pancreatic Cancers
- (2014) A. M. Heilmann et al. CANCER RESEARCH
- A Novel KLF4/LDHA Signaling Pathway Regulates Aerobic Glycolysis in and Progression of Pancreatic Cancer
- (2014) M. Shi et al. CLINICAL CANCER RESEARCH
- Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies
- (2014) Jonathan Haqq et al. EUROPEAN JOURNAL OF CANCER
- Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
- (2014) Ingunn M Stromnes et al. GUT
- PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines
- (2014) Patricia Izetti et al. INVESTIGATIONAL NEW DRUGS
- Molecular pathology of pancreatic cancer
- (2014) Yuriko Saiki et al. PATHOLOGY INTERNATIONAL
- KRAS: feeding pancreatic cancer proliferation
- (2014) Kirsten L. Bryant et al. TRENDS IN BIOCHEMICAL SCIENCES
- Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
- (2014) Julian Swierczynski WORLD JOURNAL OF GASTROENTEROLOGY
- Genetic predisposition to pancreatic cancer
- (2014) Paola Ghiorzo WORLD JOURNAL OF GASTROENTEROLOGY
- MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies
- (2014) GuemHee Baek et al. Cell Reports
- SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis
- (2013) G. Liu et al. CANCER RESEARCH
- Pankreaskarzinom im hohen Alter
- (2013) H. Nieß et al. CHIRURG
- Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells
- (2013) Zhiyuan Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA Methylation Signatures Identify Biologically Distinct Thyroid Cancer Subtypes
- (2013) Sandra Rodríguez-Rodero et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
- (2013) F. Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pancreatic cancer: why is it so hard to treat?
- (2013) Paul E. Oberstein et al. Therapeutic Advances in Gastroenterology
- S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells
- (2012) Hitoshi Sekine et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
- (2012) Matthew R. Porembka et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Inherited Pancreatic Cancer Syndromes
- (2012) Sheila Solomon et al. CANCER JOURNAL
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
- (2012) Enza Lonardo et al. CELL CYCLE
- The Pancreas Cancer Microenvironment
- (2012) C. Feig et al. CLINICAL CANCER RESEARCH
- Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
- (2012) Michael A Jacobetz et al. GUT
- Energy metabolism in cancer cells: How to explain the Warburg and Crabtree effects?
- (2012) Paolo Dell’ Antone MEDICAL HYPOTHESES
- Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
- (2012) Mangmang Li et al. MOLECULAR CELL
- SMAD4 Genetic Alterations Predict a Worse Prognosis in Patients With Pancreatic Ductal Adenocarcinoma
- (2012) Puneet Singh et al. PANCREAS
- MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
- (2012) N. V. Chaika et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Influence of Diet and Tobacco Smoking on Pancreatic Cancer Incidence in Poland in 1960–2008
- (2012) Mirosław Jarosz et al. Gastroenterology Research and Practice
- Pancreatic stellate cells: a starring role in normal and diseased pancreas
- (2012) Minoti V. Apte et al. Frontiers in Physiology
- Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)
- (2011) C. Bosetti et al. ANNALS OF ONCOLOGY
- Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose–response meta-analysis of prospective studies
- (2011) D. Aune et al. ANNALS OF ONCOLOGY
- MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer
- (2011) Jun Hao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- DNA Demethylation Dynamics
- (2011) Nidhi Bhutani et al. CELL
- TGFβ prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest
- (2011) Jon Lecanda et al. CELL CYCLE
- Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma
- (2011) A. Vincent et al. CLINICAL CANCER RESEARCH
- Epigenetic modifications in cancer
- (2011) R Kanwal et al. CLINICAL GENETICS
- A DNA methylation fingerprint of 1628 human samples
- (2011) A. F. Fernandez et al. GENOME RESEARCH
- Pancreatic cancer
- (2011) Audrey Vincent et al. LANCET
- Impact of KRAS Mutations on Clinical Outcomes in Pancreatic Cancer Patients Treated with First-line Gemcitabine-Based Chemotherapy
- (2011) S. T. Kim et al. MOLECULAR CANCER THERAPEUTICS
- Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
- (2011) D. Gaglio et al. Molecular Systems Biology
- Cancer epigenetics reaches mainstream oncology
- (2011) Manuel Rodríguez-Paredes et al. NATURE MEDICINE
- Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer
- (2011) R. A. Juergens et al. Cancer Discovery
- Genome-wide profiling at methylated promoters in pancreatic adenocarcinoma
- (2010) Noriyuki Omura et al. CANCER BIOLOGY & THERAPY
- Pancreatic cancerDNMT1expression and sensitivity toDNMT1inhibitors
- (2010) Ang Li et al. CANCER BIOLOGY & THERAPY
- Pancreatic Cancers Epigenetically Silence SIP1 and Hypomethylate and Overexpress miR-200a/200b in Association with Elevated Circulating miR-200a and miR-200b Levels
- (2010) A. Li et al. CANCER RESEARCH
- PALB2 mutations in European familial pancreatic cancer families
- (2010) EP Slater et al. CLINICAL GENETICS
- Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy
- (2010) A.S. Azmi et al. CURRENT CANCER DRUG TARGETS
- K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
- (2010) H. Chen et al. EJSO
- CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer
- (2010) Naoki Ikenaga et al. GASTROENTEROLOGY
- Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
- (2010) Eric J. Jacobs et al. INTERNATIONAL JOURNAL OF CANCER
- The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma
- (2010) Yi Zhu et al. MEDICAL ONCOLOGY
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
- (2010) S. A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Molecular Signals of Epigenetic States
- (2010) Roberto Bonasio et al. SCIENCE
- A Systems Perspective of Ras Signaling in Cancer
- (2009) E. C. Stites et al. CLINICAL CANCER RESEARCH
- Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications
- (2009) M. T. McCabe et al. CLINICAL CANCER RESEARCH
- SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer
- (2009) A. Blackford et al. CLINICAL CANCER RESEARCH
- Analysis of the Gene Coding for the BRCA2-Interacting Protein PALB2 in Familial and Sporadic Pancreatic Cancer
- (2009) Marc D. Tischkowitz et al. GASTROENTEROLOGY
- An operational definition of epigenetics
- (2009) S. L. Berger et al. GENES & DEVELOPMENT
- Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
- (2009) S. Jones et al. SCIENCE
- Molecular Characterization of Pancreatic Neoplasms
- (2008) Chanjuan Shi et al. ADVANCES IN ANATOMIC PATHOLOGY
- Polymorphisms of p16, p27, p73, and MDM2 Modulate Response and Survival of Pancreatic Cancer Patients Treated with Preoperative Chemoradiation
- (2008) Jinyun Chen et al. ANNALS OF SURGICAL ONCOLOGY
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
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