- Home
- Publications
- Publication Search
- Publication Details
Title
Exploiting the folate receptor α in oncology
Authors
Keywords
-
Journal
Nature Reviews Clinical Oncology
Volume 17, Issue 6, Pages 349-359
Publisher
Springer Science and Business Media LLC
Online
2020-03-09
DOI
10.1038/s41571-020-0339-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Bench to Bedside: Albumin Binders for Improved Cancer Radioligand Therapies
- (2019) Joseph Lau et al. BIOCONJUGATE CHEMISTRY
- Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial
- (2019) Johann S de Bono et al. LANCET ONCOLOGY
- Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
- (2019) Barbara Frigerio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients (pts) with platinum-resistant ovarian cancer: Final findings from the FORWARD II study.
- (2019) David M. O'Malley et al. JOURNAL OF CLINICAL ONCOLOGY
- Expert recommendations on the management of hypertension in patients with ovarian and cervical cancer receiving bevacizumab in the UK
- (2019) Chris Plummer et al. BRITISH JOURNAL OF CANCER
- Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study
- (2019) Udai Banerji et al. LANCET ONCOLOGY
- 992OFORWARD I (GOG 3011): A phase III study of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), versus chemotherapy in patients (pts) with platinum-resistant ovarian cancer (PROC)
- (2019) K Moore et al. ANNALS OF ONCOLOGY
- Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients
- (2018) Kimberly R. Kalli et al. CLINICAL CANCER RESEARCH
- Initial safety and activity findings from a phase IB escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα-targeting antibody-drug conjugate (ADC), with pembrolizumab in platinum-resistant epithelial ovarian cancer (EOC) patients
- (2018) U.A. Matulonis et al. GYNECOLOGIC ONCOLOGY
- Advances in targeting the folate receptor in the treatment/imaging of cancers
- (2018) Marcos Fernández et al. Chemical Science
- Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
- (2018) Joseph A. Reddy et al. Scientific Reports
- Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager
- (2018) Anna Wing et al. Cancer Immunology Research
- Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancer
- (2018) Kathleen N. Moore et al. GYNECOLOGIC ONCOLOGY
- MORAb-202, an antibody drug conjugate utilizing humanized anti-human FRa farletuzumab and the microtubule-targeting agent eribulin, has potent anti-tumor activity
- (2018) Xin Cheng et al. MOLECULAR CANCER THERAPEUTICS
- Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate
- (2018) Christian Brand et al. EJNMMI Research
- Targeting macrophages: therapeutic approaches in cancer
- (2018) Luca Cassetta et al. NATURE REVIEWS DRUG DISCOVERY
- Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha–Targeting Antibody–Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study
- (2017) Kathleen N. Moore et al. JOURNAL OF CLINICAL ONCOLOGY
- Chimeric antigen receptor T-cell therapy — assessment and management of toxicities
- (2017) Sattva S. Neelapu et al. Nature Reviews Clinical Oncology
- Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies
- (2017) Jiayin Shen et al. Oncotarget
- LBA40_PRTARGET: A RANDOMIZED, PHASE II TRIAL COMPARING VINTAFOLIDE VERSUS VINTAFOLIDE PLUS DOCETAXEL, VERSUS DOCETAXEL ALONE IN SECOND-LINE TREATMENT OF FOLATE-RECEPTOR-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC) PATIENTS
- (2017) N. Hanna et al. ANNALS OF ONCOLOGY
- Outcomes After Oncoplastic Breast-Conserving Surgery in Breast Cancer Patients: A Systematic Literature Review
- (2016) Lucy De La Cruz et al. ANNALS OF SURGICAL ONCOLOGY
- Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes
- (2016) Ling Han et al. CURRENT BIOLOGY
- Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)
- (2016) Linda W. Martin et al. JOURNAL OF CLINICAL ONCOLOGY
- A Randomized, Double-Blind, Placebo-Controlled, Phase III Study to Assess Efficacy and Safety of Weekly Farletuzumab in Combination With Carboplatin and Taxane in Patients With Ovarian Cancer in First Platinum-Sensitive Relapse
- (2016) Ignace Vergote et al. JOURNAL OF CLINICAL ONCOLOGY
- Critical parameters in targeted drug development: the pharmacological audit trail
- (2016) Udai Banerji et al. SEMINARS IN ONCOLOGY
- Profile of farletuzumab and its potential in the treatment of solid tumors
- (2016) Seiya Sato et al. OncoTargets and Therapy
- Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17
- (2016) Quirijn R.J.G. Tummers et al. Oncotarget
- Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients
- (2016) Leonora S.F. Boogerd et al. Oncotarget
- Targeting folate receptor alpha for cancer treatment
- (2016) Anthony Cheung et al. Oncotarget
- Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of 161Tb-folate and 177Lu-folate
- (2016) Stephanie Haller et al. EJNMMI Research
- Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha–Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models
- (2016) Jose F. Ponte et al. NEOPLASIA
- Molecular Imaging of Folate Receptor β–Positive Macrophages during Acute Lung Inflammation
- (2015) Wei Han et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments
- (2015) J. A. Ledermann et al. ANNALS OF ONCOLOGY
- Complications of hyperglycaemia with PI3K–AKT–mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials
- (2015) E Geuna et al. BRITISH JOURNAL OF CANCER
- Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha
- (2015) Mariann F. Hansen et al. CELLULAR SIGNALLING
- A randomized double-blind phase III trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD/Doxil®/Caelyx®) in combination versus PLD in participants with platinum-resistant ovarian cancer (PROCEED) (NCT01170650)
- (2015) A.M. Oza et al. GYNECOLOGIC ONCOLOGY
- Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression
- (2015) Akira Kurosaki et al. INTERNATIONAL JOURNAL OF CANCER
- Does Aggressive Surgery Improve Outcomes? Interaction Between Preoperative Disease Burden and Complex Surgery in Patients With Advanced-Stage Ovarian Cancer: An Analysis of GOG 182
- (2015) Neil S. Horowitz et al. JOURNAL OF CLINICAL ONCOLOGY
- IMGN853, a Folate Receptor- (FR )-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR -Expressing Tumors
- (2015) O. Ab et al. MOLECULAR CANCER THERAPEUTICS
- Folate receptor-targeted radionuclide therapy: preclinical investigation of anti-tumor effects and potential radionephropathy
- (2015) Stephanie Haller et al. NUCLEAR MEDICINE AND BIOLOGY
- Assessment of folate receptor-β expression in human neoplastic tissues
- (2015) Jiayin Shen et al. Oncotarget
- Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors
- (2015) Ignace Vergote et al. Therapeutic Advances in Medical Oncology
- Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance
- (2015) Daniel J. O'Shannessy et al. Oncotarget
- Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study
- (2014) M Köbel et al. BRITISH JOURNAL OF CANCER
- Immunotherapy Targeting Folate Receptor Induces Cell Death Associated with Autophagy in Ovarian Cancer
- (2014) Y. Wen et al. CLINICAL CANCER RESEARCH
- A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors
- (2014) P. P. Peethambaram et al. INVESTIGATIONAL NEW DRUGS
- A folate-integrated magnetic polymer micelle for MRI and dual targeted drug delivery
- (2014) Lijiao Ao et al. Nanoscale
- Juno is the egg Izumo receptor and is essential for mammalian fertilization
- (2014) Enrica Bianchi et al. NATURE
- The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity
- (2013) JianMin Lin et al. CANCER BIOLOGY & THERAPY
- Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer
- (2013) Deborah K. Armstrong et al. GYNECOLOGIC ONCOLOGY
- PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer
- (2013) R. Wendel Naumann et al. JOURNAL OF CLINICAL ONCOLOGY
- A Phase I Study of Folate Immune Therapy (EC90 Vaccine Administered With GPI-0100 Adjuvant Followed by EC17) in Patients With Renal Cell Carcinoma
- (2013) Robert J. Amato et al. JOURNAL OF IMMUNOTHERAPY
- Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells
- (2013) Anna Tochowicz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural basis for molecular recognition of folic acid by folate receptors
- (2013) Chen Chen et al. NATURE
- Clinical Significance of Folate Receptor β–expressing Tumor-associated Macrophages in Pancreatic Cancer
- (2012) Hiroshi Kurahara et al. ANNALS OF SURGICAL ONCOLOGY
- The human proton-coupled folate transporter
- (2012) Sita Kugel Desmoulin et al. CANCER BIOLOGY & THERAPY
- Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors
- (2012) Patricia M. LoRusso et al. JOURNAL OF CLINICAL ONCOLOGY
- DOTA Conjugate with an Albumin-Binding Entity Enables the First Folic Acid-Targeted 177Lu-Radionuclide Tumor Therapy in Mice
- (2012) C. Muller et al. JOURNAL OF NUCLEAR MEDICINE
- High Expression of Folate Receptor Alpha in Lung Cancer Correlates with Adenocarcinoma Histology and Mutation
- (2012) Maria Ines Nunez et al. Journal of Thoracic Oncology
- A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
- (2012) Lana E Kandalaft et al. Journal of Translational Medicine
- Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease
- (2012) Daniel J O’Shannessy et al. SpringerPlus
- Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia
- (2011) Rongbao Zhao et al. Annual Review of Nutrition
- In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)
- (2011) D.-G. Song et al. CANCER RESEARCH
- Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity
- (2011) S. M. Rudman et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
- (2011) Gooitzen M van Dam et al. NATURE MEDICINE
- The role of folate receptor alpha (FRα) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy
- (2010) J E Nutt et al. BRITISH JOURNAL OF CANCER
- Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor , in Epithelial Ovarian Cancer: a Phase I Study
- (2010) J. A. Konner et al. CLINICAL CANCER RESEARCH
- Breast Cancers: MR Imaging of Folate-Receptor Expression with the Folate-Specific Nanoparticle P1133
- (2010) Reinhard Meier et al. RADIOLOGY
- A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
- (2008) W. Xia et al. BLOOD
- Folate receptor alpha as a tumor target in epithelial ovarian cancer
- (2008) Kimberly R. Kalli et al. GYNECOLOGIC ONCOLOGY
- Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor-Positive Solid Tumors
- (2008) R. E. Fisher et al. JOURNAL OF NUCLEAR MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started