Article
Oncology
Qingqing Dai, Fei Song, Xincheng Li, Fan Huang, Hongchuan Zhao
Summary: IQGAPs play an essential role in hepatocellular carcinoma (HCC) progression. This study found that IQGAP1 and 3 were upregulated in HCC tissues, while IQGAP2 was downregulated. Positive expression of IQGAP1 and 3 was associated with poor prognosis, while positive expression of IQGAP2 was associated with better prognosis.
Article
Oncology
Jiaxing Guo, Meiyuan Huang, Shuang Deng, Haiyan Wang, Zuli Wang, Bokang Yan
Summary: In this study, we reveal the previously unrecognized role of RPLP2 in HCC and provide a new regulatory mechanism of ferroptosis, indicating that RPLP2 may be a novel therapeutic target for HCC. Elevated level of RPLP2 is strongly associated with advanced clinicopathologic features and predicts poor prognosis of HCC patients. Inhibition of RPLP2 could lead to the acceleration of ferroptosis to suppress tumor progression of HCC. Drug sensitivity analysis predicts many drugs that potentially target RPLP2.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Yugang Huang, Xiuwen Chen, Li Wang, Tieyan Wang, Xianbin Tang, Xiaomin Su
Summary: Overexpression of Centromere Protein F (CENPF) is significantly correlated with tumorigenesis and poor prognosis in hepatocellular carcinoma (HCC) patients. Down-regulation of CENPF inhibits cell proliferation, migration, and invasion, while slightly promoting apoptosis in human HepG2 cells. Gene-set enrichment analysis (GSEA) reveals that CENPF is mainly enriched in cell cycle regulation, particularly during G2/M transition of mitosis in HCC. Immune infiltration analysis shows significant differences in immune cell populations in HCC samples with different levels of CENPF expression. These findings suggest that CENPF may serve as a potential prognostic biomarker and therapeutic target for HCC.
Article
Oncology
Jukun Wang, Chao Zhang, Xin Chen, Yu Li, Ang Li, Dongbin Liu, Fei Li, Tao Luo
Summary: This study found that CXC chemokines can influence the survival of patients with hepatocellular carcinoma (HCC) by recruiting different types of immune cells into the tumor microenvironment.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Jiali Meng, Yuanchao Wei, Qing Deng, Ling Li, Xiaolong Li
Summary: This study found that TOP2A may serve as a new biomarker and therapeutic target for hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Biochemistry & Molecular Biology
Ziyu Meng, Xue Geng, Xiaoyue Lin, Ziwei Wang, Danchun Chen, Hua Liang, Ying Zhu, Yutong Sui
Summary: Hepatocellular carcinoma (HCC) is difficult to diagnose early and has resistance to therapeutic drugs. SLC37A3 is significantly upregulated in HCC and associated with tumor stages. Knockdown of SLC37A3 inhibits HCC tumor formation and cell proliferation, promotes apoptosis, and affects glucose metabolism regulation. SLC37A3 may serve as a potential diagnostic and prognostic biomarker for HCC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Hongtao Fu, Kun Li, Shui Wang, Yuming Li
Summary: Breast cancer is the most frequent cancer in women globally. This study explored new biomarkers for breast cancer diagnosis and found that CCNB1 expression was higher in breast cancer tissues compared to normal tissues. CCNB1 was significantly related to survival time, tumor mutation burden, and other factors in breast cancer. The ACO26401.3/CCNB1-miR-139-5p axis was identified as a promising upstream pathway related to CCNB1 in breast cancer.
Article
Biochemistry & Molecular Biology
Yujing Zhang, Xinyue Yang, Yang Hu, Xin Huang
Summary: In this study, the role of EXOSCs, especially EXOSC5, in hepatocellular carcinoma (HCC) was systematically investigated using multiple public databases and experimental validation. It was found that EXOSCs were elevated in HCC and their over-expression could predict HCC to some extent. Higher mRNA expressions of specific EXOSCs were related to clinical cancer stage, shorter overall survival and disease-free survival in HCC patients. Bioinformatic analyses also revealed the involvement of EXOSCs in RNA metabolism and immune cell infiltration. Additionally, it was discovered that EXOSC5 promoted cell growth and proliferation in HCC via activated STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kai Zhang, Enwu Yuan
Summary: This study created a unique prognostic profile based on NK cell marker genes that can accurately predict the efficacy of immunotherapy for HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ke Xu, Yu Liu, Huiyan Luo, Tengfei Wang
Summary: This study highlights the importance of efferocytosis in the progression of hepatocellular carcinoma (HCC) and develops a predictive model based on efferocytosis-related genes (ERGs) for assessing patient risk and prognosis. The results also reveal the presence of distinct immune environments and prognostic stratification within HCC based on ERGs. These findings contribute to the development of personalized treatment strategies, including immunotherapy and chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Slawomir Wolczynski, Guangming Li, Xiangdong Li
Summary: This study aims to elucidate the potential role and molecular mechanism of circZKSaa in the regulation of hepatocellular carcinoma (HCC) progression. Through a series of experiments, it was found that circZKSaa inhibited HCC progression and sensitized HCC cells to sorafenib. Furthermore, the high expression of cicZKSCAN1 in sorafenib-treated HCC cells was regulated by QKI-5. These findings demonstrate that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.
Article
Medicine, General & Internal
Wei Yan, Dan-Dan Wang, He-Da Zhang, Jinny Huang, Jun-Chen Hou, Su-Jin Yang, Jian Zhang, Ling Lu, Qian Zhang
Summary: Through the analysis of publicly available databases and bioinformatics, we found that SMC gene family has important expression patterns, potential functions, and prognostic values in hepatocellular carcinoma (HCC). Upregulation of SMC2, SMC3, and SMC4 is associated with clinical stage and poor prognosis of HCC. SMC family members are involved in various biological processes underlying tumorigenesis.
Article
Oncology
Jiahao Yu, Weirui Zhang, Dawei Ding, Yinan Hu, Guanya Guo, Jingbo Wang, Ying Han
Summary: The study suggests that Pseudouridine 5'-phosphatase (PUDP) may function as an oncogene in hepatocellular carcinoma (HCC) and is positively correlated with the infiltration of tumor-promoting immune cells. Patients with high PUDP expression are less likely to benefit from immunotherapy and PUDP serves as an independent risk factor for HCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Yuping Bai, Wenbo Qi, Le Liu, Jing Zhang, Lan Pang, Tiejun Gan, Pengfei Wang, Chen Wang, Hao Chen
Summary: This study constructed seven prognostic markers related to HCC survival. Patients were divided into high and low risk groups, with significant differences between them shown in KM curve analysis. Stratified analysis revealed significant differences in risk values among different ages, genders, stages, and grades, which could serve as independent predictors.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Multidisciplinary
Shengru Chen, Qinghua Zhang, Dongke Rong, Yue Xu, Jinfeng Zhang, Fangfang Pei, He Bai, Yan-Xing Shang, Shan Lin, Qiao Jin, Haitao Hong, Can Wang, Wensheng Yan, Haizhong Guo, Tao Zhu, Lin Gu, Yu Gong, Qian Li, Lingfei Wang, Gang-Qin Liu, Kui-juan Jin, Er-Jia Guo
Summary: This study reports the creation of morphotropic grain boundaries in laterally interconnected cobaltite homostructures. By modulating and isolating electronic states and magnetic behavior through the grain boundaries, artificially engineered functionalities can be achieved in the planar matrix.
ADVANCED MATERIALS
(2023)
Letter
Surgery
Qiyuan Huang, Xiaojuan Jiang, Guo Chen, Tao Zhu
ASIAN JOURNAL OF SURGERY
(2023)
Article
Nanoscience & Nanotechnology
Huiying Xiang, Yuan Yuan, Cheng Zhang, Xu Dai, Tao Zhu, Linbo Song, Yu Gai, Ruijin Liao
Summary: By studying the effects of surfaces with different pore sizes and porosities on the performance of SLIPSs, it was found that small pores and high porosity are beneficial for the preparation of durable anti-icing SLIPSs, which can greatly improve the lubricant stability and achieve rapid self-healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Automation & Control Systems
Ming Cai, Tao Zhu, Yadong Gong, Xingjun Gao, Qiang Gong, Ning Yu
Summary: This study investigates the impact of rhenium element and grain boundaries on the dislocation slip during the grinding process of Ni-based superalloys. The experiments reveal that the rhenium element significantly enhances the high-temperature durability of the alloys. Under low-temperature conditions, DD5 exhibits better machining quality compared to DD98, while under high-temperature conditions, DD5 has lower machining quality. Moreover, the surface quality of GH4169 is better than DD5 due to grain boundaries, and their chip morphologies differ significantly.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Oncology
Fan Yang, Chloe Shay, Marin Abousaud, Chris Tang, Yamin Li, Zhaohui Qin, Nabil F. Saba, Yong Teng
Summary: This study analyzes immune-related adverse events (irAEs) associated with seven FDA-approved immune checkpoint inhibitors (ICIs) in cancer treatment, revealing the pattern of toxicity burden among patients. The findings highlight that irAEs related to anti-PD-1 ICIs require fewer hospital care resources compared to anti-PD-L1 and anti-CTLA-4 ICIs. Age and sex have specific impacts on tissue and organ toxicities of ICIs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Jianbin Zhang, Conghui Shang, Xinyue Dai, Yao Zhang, Tao Zhu, Nan Zhou, Hua Xu, Rusen Yang, Xiaobo Li
Summary: Germanium arsenic (GeAs), a promising two-dimensional material, has high carrier mobility and tunable bandgap, making it suitable for electronic and optoelectronic devices. However, the rapid degradation of GeAs in the environment hampers its practical application. This study presents a method to stabilize GeAs using a graphene capping layer, which effectively suppresses environmental degradation and improves device performance. The encapsulated GeAs photodetectors maintained key electronic properties for over 3 months under ambient conditions, with an improved responsivity 20 times higher than pure GeAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Endocrinology & Metabolism
Tao Zhu, Xu Chen, Shenglu Jiang
Summary: Transplantation of brown adipose tissue (BAT), engineered thermogenic progenitor cells, and adipocytes have been studied for their potential in improving obesity and metabolic disorders. However, the whitening of the brown fat graft and impaired metabolic function are significant challenges. This review discusses specific experiment designs, graft outcomes, and metabolic benefits, providing guidance for further investigation and innovation in BAT transplantation methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Huiying Xiang, Yuan Yuan, Tao Zhu, Xu Dai, Cheng Zhang, Yu Gai, Ruijin Liao
Summary: In recent years, the depletion of lubricant in slippery lubricant-infused porous surface (SLIPS) has been a concern, limiting its application in anti-icing. This study focuses on the lubricant storage, depletion, and self-healing rate after depletion to improve the anti-icing durability of SLIPS. By fabricating a dendritic porous structure and optimizing the pore depth ratio and surface porosity, the dendritic slippery surface (Y-SLIPS) shows better anti-icing durability compared to traditional slippery surface (I-SLIPS). The Y-SLIPS can withstand more frosting/defrosting cycles and icing/deicing cycles while maintaining extremely low ice-adhesion strength.
MATERIALS TODAY PHYSICS
(2023)
Article
Mechanics
Dongdong Chen, Xiaoyu Sun, Shoune Xiao, Guangwu Yang, Bing Yang, Tao Zhu, Mingmeng Wang
Summary: This study investigated the energy-absorbing mechanisms of composite structures subjected to quasistatic and dynamic axial crushing loads. Double hat-shaped composite tubes made of CFRP and GFRP were tested and analyzed. Results showed that the CFRP structures had reduced energy absorption at higher loading rates, while the GFRP structures remained relatively constant. A finite element model considering strain rate effects accurately predicted the crushing behavior. Mechanical properties of the composite materials played a critical role in the distinct responses of CFRP and GFRP structures. The findings contribute to the crashworthiness design of composite energy-absorbing structures.
COMPOSITE STRUCTURES
(2023)
Article
Biochemistry & Molecular Biology
Shanzhu Guo, Yue Jiang, Jingjing Jiao, Yan Shi, Tao Zhu, Long Li
Summary: In this study, a gelatin-based biomimetic three-layer vascular scaffold with spatial alignment features mimicking the natural structure of blood vessels was successfully constructed using a sequential electrospinning strategy combined with folding and rolling manipulation. The scaffold could fully mimic the natural multi-layer structures of blood vessels and showed great potential for guiding the spatial arrangement of cells in blood vessels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Mechanical
Long Yang, Bing Yang, Guangwu Yang, Lanxin Jiang, Shoune Xiao, Tao Zhu
Summary: Fa-N curves and σn_s-N curves of bolted connections under different geometric and load parameters were obtained through tensile-shear fatigue tests. The correlation of these curves was poor and did not meet engineering requirements. To address this issue, an equivalent structural stress calculation model considering the bolt load as the input condition was derived. A plate-shell finite element model for bolted connections was established to extract load parameters for bolts and obtain the equivalent structural stress at the crack initiation position. Finally, a fatigue evaluation method based on equivalent structural stress and considering geometric and load parameters was developed for bolted connections.
INTERNATIONAL JOURNAL OF FATIGUE
(2023)
Article
Optics
Laiyang Dang, Bowen Zheng, Yulong Cao, Chaoze Zhang, Ligang Huang, Paul Ikechukwu Iroegbu, Leilei Shi, Tianyi Lan, Jiali Li, Guolu Yin, Tao Zhu
Summary: We have proposed and demonstrated a fiber laser scheme with wide tunability and ultra-narrow linewidth by utilizing an original Fabry-Perot laser main cavity and a distributed external feedback structure. This was achieved by injecting a distributed feedback signal into the main cavity to induce intense mode competition. The obtained single frequency fiber laser exhibits excellent performance with a side mode suppression ratio of 69 dB, an output linewidth of 570 Hz, a white frequency noise of 110 Hz(2)/Hz at a high frequency offset, and a relative intensity noise less than -140 dB/Hz. The laser also maintains high spectral purity under different pump powers for each wavelength channel. This work presents a promising method for obtaining tunable ultra-narrow linewidth lasers.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Qiang Wang, Fengdan Zhu, Yanjuan Cai, Tao Zhu, Xiaolan Lu
Summary: A nomogram model was established to predict the risk of active tuberculosis (ATB) and differentiate it from inactive tuberculosis (IATB) using the concentration of interferon-γ (IFN-γ) and clinical characteristics. The model was trained and validated in different cohorts and combined with adenosine deaminase (ADA) to improve the performance in ATB cases with pleural effusion (PE). The diagnostic nomogram model showed good sensitivity and specificity in both the training and validation cohorts, and the combination with ADA further improved the performance.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Electrical & Electronic
Hongxia Li, Yuxin Lu, Tao Zhu, Rongxin Cao, Yuxiong Xue, Xianghua Zeng
Summary: The impact of gamma-irradiation on the properties of unpacked InGaN/GaN LEDs was investigated. Photoluminescence spectra revealed three peaks corresponding to different materials, and their peak positions remained unaffected by gamma irradiation doses up to 100 kGy. However, the intensities of the peaks were changed with gamma irradiation. The LED properties, including operating voltage, luminous flux, and photoelectric conversion efficiency, were all influenced by the total gamma-ray doses.
MICROELECTRONICS RELIABILITY
(2023)
Article
Engineering, Mechanical
Tao Zhu, Haoxu Ding, Chao Wang, Yuxin Liu, Shoune Xiao, Guangwu Yang, Bing Yang
Summary: The paper focuses on the quasi-static fracture experiments of SUS301L-MT under different stress states in order to improve the accuracy of the corresponding finite element simulation and guide the design of vehicle crashworthiness. The fracture behavior, locations, and strains of the material were obtained through tests, and the parameters of the GISSMO failure model were calibrated and verified. Results show good agreement between simulation and experimental data for the force-displacement curve, but further study and improvement are needed for the strain distribution.
CHINESE JOURNAL OF MECHANICAL ENGINEERING
(2023)