The stressosome, a caspase‐8‐activating signalling complex assembled in response to cell stress in an ATG5‐mediated manner

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer

(2020) Laura K. Hillert et al.   CELL DEATH AND DIFFERENTIATION

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

(2020) Mable Lam et al.   eLife

Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes

(2020) Tatsuya Hattori et al.   CELL DEATH AND DIFFERENTIATION

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

(2020) Alisa F. Zyryanova et al.   MOLECULAR CELL

Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic–induced necroptosis

(2020) Burak Uzunparmak et al.   JCI Insight

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

FLIP as a therapeutic target in cancer

(2018) Luke Humphreys et al.   FEBS Journal

Caspase-8 function, and phosphorylation, in cell migration

(2018) Nadine Keller et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

(2018) Giulia Fianco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

(2017) Raffaella Iurlaro et al.   MOLECULAR AND CELLULAR BIOLOGY

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

Caspase-9: structure, mechanisms and clinical application

(2017) Ping Li et al.   Oncotarget

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

(2017) Giulia Fianco et al.   eLife

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

DED or alive: assembly and regulation of the death effector domain complexes

(2015) J S Riley et al.   Cell Death & Disease

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

(2014) Shane Deegan et al.   Autophagy

Caspase-8 as a Regulator of Tumor Cell Motility

(2014) R.P. Graf et al.   CURRENT MOLECULAR MEDICINE

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Applying Physics-Based Scoring to Calculate Free Energies of Binding for Single Amino Acid Mutations in Protein-Protein Complexes

(2013) Hege Beard et al.   PLoS One

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA