ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

(2019) Yao Liang Wong et al.   eLife

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

(2019) Huib H. Rabouw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular eIF2B subunit localisation: implications for the integrated stress response and its control by small molecule drugs

(2019) Rachel E. Hodgson et al.   MOLECULAR BIOLOGY OF THE CELL

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

(2019) Lillian R. Kenner et al.   SCIENCE

Structural basis for eIF2B inhibition in integrated stress response

(2019) Kazuhiro Kashiwagi et al.   SCIENCE

Structural basis for the inhibition of translation through eIF2α phosphorylation

(2019) Yuliya Gordiyenko et al.   Nature Communications

The structural basis of translational control by eIF2 phosphorylation

(2019) Tomas Adomavicius et al.   Nature Communications

Vanishing white matter: deregulated integrated stress response as therapy target

(2019) Truus E. M. Abbink et al.   Annals of Clinical and Translational Neurology

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

(2019) Ping Jun Zhu et al.   SCIENCE

A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α

(2018) Ana Crespillo-Casado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

(2018) Jordan C. Tsai et al.   SCIENCE

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

(2018) Yao Liang Wong et al.   eLife

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

(2017) Austin Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

(2017) Ana Crespillo-Casado et al.   eLife

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of eukaryotic translation initiation factor 2B

(2016) Kazuhiro Kashiwagi et al.   NATURE

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells

(2016) Yusuke Sekine et al.   PLoS One

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The  /Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo

(2010) K. Dev et al.   MOLECULAR AND CELLULAR BIOLOGY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS