The detection and functions of RNA modification m6A based on m6A writers and erasers

The m6A methylome of SARS-CoV-2 in host cells

(2021) Jun’e Liu et al.   CELL RESEARCH

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection

(2021) Na Li et al.   Cell Reports

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

(2020) Bo Tang et al.   Molecular Cancer

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

(2020) Jun Liu et al.   SCIENCE

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

(2020) Jiazhen Wang et al.   Cell Stem Cell

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

(2020) Chao Shen et al.   Cell Stem Cell

The potential role of RNA N6-methyladenosine in Cancer progression

(2020) Tianyi Wang et al.   Molecular Cancer

A metabolic labeling method detects m6A transcriptome-wide at single base resolution

(2020) Xiao Shu et al.   Nature Chemical Biology

Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine

(2020) Ye Wang et al.   Nature Chemical Biology

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

(2020) Jiexin Li et al.   NUCLEIC ACIDS RESEARCH

Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity

(2020) Ilenia Pellarin et al.   ONCOGENE

Limits in the detection of m6A changes using MeRIP/m6A-seq

(2020) Alexa B. R. McIntyre et al.   Scientific Reports

N6-Methyladenosine Modification of Hepatitis B and C Viral RNAs Attenuates Host Innate Immunity via RIG-I Signaling

(2020) Geon-Woo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability

(2020) Zijie Zhang et al.   NATURE GENETICS

Photoactivatable RNA N 6 ‐Methyladenosine Editing with CRISPR‐Cas13

(2020) Jie Zhao et al.   Small

RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting

(2020) Shuo Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct RNAN-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates

(2020) Joel D. W. Toh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRADES: Targeted RNA Demethylation by SunTag System

(2020) Jing Mo et al.   Advanced Science

Programmable N6-methyladenosine modification of CDCP1 mRNA by RCas9-methyltransferase like 3 conjugates promotes bladder cancer development

(2020) Xiaoling Ying et al.   Molecular Cancer

FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

(2019) Mathieu Ringeard et al.   NATURE

N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling

(2019) Abhirami Visvanathan et al.   Genes

N6-Methyladenosine and Viral Infection

(2019) Wei Dang et al.   Frontiers in Microbiology

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

(2019) Xiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

The Critical Role of RNA m6A Methylation in Cancer

(2019) Qing Lan et al.   CANCER RESEARCH

m6A RNA methylation regulators contribute to malignant progression and have clinical prognostic impact in gliomas

(2019) Rui-Chao Chai et al.   Aging-US

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling

(2019) Miguel Angel Garcia-Campos et al.   CELL

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

(2019) Jun Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

(2019) Lei Wang et al.   SCIENCE

Regulation of Viral Infection by the RNA Modification N6-methyladenosine

(2019) Graham D. Williams et al.   Annual Review of Virology

Single-base mapping of m6A by an antibody-independent method

(2019) Zhang Zhang et al.   Science Advances

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

(2019) Wen Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

(2019) Xiao-Min Liu et al.   Nature Chemical Biology

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

(2019) Tianfang Xia et al.   PATHOLOGY RESEARCH AND PRACTICE

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

(2019) Yang Liu et al.   SCIENCE

m6A RNA Methylation Controls Proliferation of Human Glioma Cells by Influencing Cell Apoptosis

(2019) Feng Li et al.   CYTOGENETIC AND GENOME RESEARCH

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

(2019) Wendan Ren et al.   Nature Communications

Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems

(2019) Liang-Zhong Yang et al.   MOLECULAR CELL

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

(2018) Yuan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

N6-methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

(2018) Wuxun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

Reversible RNA Modification N 1 -methyladenosine (m 1 A) in mRNA and tRNA

(2018) Chi Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

An Elongation- and Ligation-Based qPCR Amplification Method for the Radiolabeling-Free Detection of Locus-Specific N 6 -Methyladenosine Modification

(2018) Yu Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of ribonucleoside modifications by liquid chromatography coupled with mass spectrometry

(2018) Manasses Jora et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI

(2017) Kamil Růžička et al.   NEW PHYTOLOGIST

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

(2016) Gianluigi Lichinchi et al.   Cell Host & Microbe

N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

(2016) Nandan S. Gokhale et al.   Cell Host & Microbe

Posttranscriptional m 6 A Editing of HIV-1 mRNAs Enhances Viral Gene Expression

(2016) Edward M. Kennedy et al.   Cell Host & Microbe

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

Structural insights into the molecular mechanism of the m6A writer complex

(2016) Paweł Śledź et al.   eLife

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

(2016) Gianluigi Lichinchi et al.   Nature Microbiology

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

DecreasedN6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated WithFTOExpression Rather ThanALKBH5

(2015) Fan Shen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-Throughput Sequencing Technologies

(2015) Jason A. Reuter et al.   MOLECULAR CELL

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Functional annotation of native enhancers with a Cas9–histone demethylase fusion

(2015) Nicola A Kearns et al.   NATURE METHODS

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

(2014) Chao Xu et al.   Nature Chemical Biology

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

m6A mRNA Methylation: A New Circadian Pacesetter

(2013) Michael H. Hastings   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

(2013) Keiko Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iCLIP: Protein–RNA interactions at nucleotide resolution

(2013) Ina Huppertz et al.   METHODS

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

(2013) Ye Fu et al.   Nature Communications

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

FoxM1: a potential drug target for glioma

(2012) Yu Li et al.   Future Oncology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis

(2011) C. F. Hongay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The YTH Domain Is a Novel RNA Binding Domain

(2010) Zhaiyi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Nuclear Degradation of Wilms Tumor 1-associating Protein and Survivin Splice Variant Switching Underlie IGF-1-mediated Survival

(2009) Theodore W. Small et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS