Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity

Epithelial ovarian cancer

(2019) Stephanie Lheureux et al.   LANCET

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

(2019) Maura Sonego et al.   Science Advances

Identification and Characterization of a New Platinum-Induced TP53 Mutation in MDAH Ovarian Cancer Cells

(2019) Ilaria Lorenzon et al.   Cells

Systematic profiling of alternative splicing signature reveals prognostic predictor for ovarian cancer

(2018) Junyong Zhu et al.   GYNECOLOGIC ONCOLOGY

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

(2018) Michael Seiler et al.   NATURE MEDICINE

Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis

(2018) Ilenia Segatto et al.   CANCER RESEARCH

Mechanisms of Drug Resistance in High-Grade Serous Ovarian Cancer

(2018) Alison E. Freimund et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Targeting DNA Damage Response and Repair as a Therapeutic Strategy for Ovarian Cancer

(2018) Panagiotis A. Konstantinopoulos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Chemotherapy induces alternative transcription and splicing: Facts and hopes for cancer treatment

(2017) Charles A. Lambert et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF

(2017) Ken-ichi Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

(2017) Stefan Meyer et al.   Cell Death & Disease

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells

(2017) Maura Sonego et al.   Scientific Reports

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

Therapeutic targeting of splicing in cancer

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining

(2016) Lahcen Jaafar et al.   NUCLEIC ACIDS RESEARCH

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold

(2016) Gavin J. Knott et al.   NUCLEIC ACIDS RESEARCH

Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

(2015) Maude Gabriel et al.   BMC CANCER

PSF: nuclear busy-body or nuclear facilitator?

(2015) Christopher A. Yarosh et al.   Wiley Interdisciplinary Reviews-RNA

Ovarian cancer

(2014) Gordon C Jayson et al.   LANCET

Expression of human BRCA1Δ17–19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response

(2013) Jan Sevcik et al.   CELLULAR SIGNALLING

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer

(2013) Maura Sonego et al.   EMBO Molecular Medicine

PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells

(2013) Tamotsu Tsukahara et al.   Biomed Research International

The BRCA1 alternative splicing variant Δ14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells

(2012) Jan Sevcik et al.   CELLULAR SIGNALLING

Cisplatin treatment leads to changes in nuclear protein and microRNA expression

(2012) Guanglin Zhang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

(2010) Valerie Edmond et al.   EMBO JOURNAL

Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

(2010) Florian Heyd et al.   MOLECULAR CELL

Nuclear proteome analysis of cisplatin-treated HeLa cells

(2010) Wei Wu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Impacts of ERCC1 Gene Exon VIII Alternative Splicing on Cisplatin-Resistance in Ovarian Cancer Cells

(2009) Yehong Sun et al.   CANCER INVESTIGATION

E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

(2008) G Merdzhanova et al.   CELL DEATH AND DIFFERENTIATION

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA