A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease

Age-related alteration in HNE elimination enzymes

(2021) Hongqiao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Intracellular mRNA transport and localized translation

(2021) Sulagna Das et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Redox-active phytoconstituents ameliorate cell damage and inflammation in rat hippocampal neurons exposed to hyperglycemia+Aβ1-42 peptide

(2021) Zubeyir Elmazoglu et al.   NEUROCHEMISTRY INTERNATIONAL

3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases

(2020) Maria Bandookwala et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance

(2020) Hongsheng Zhang et al.   JOURNAL OF NEUROSCIENCE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

(2020) D. Allan Butterfield et al.   NEUROBIOLOGY OF DISEASE

Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology

(2020) Azhaar Ashraf et al.   Alzheimers Research & Therapy

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression

(2020) Cristina Fernández-Mendívil et al.   Antioxidants

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

(2020) Chiara Lanzillotta et al.   Antioxidants

Postmortem Protein Degradation as a Tool to Estimate the PMI: A Systematic Review

(2020) Angela Zissler et al.   Diagnostics

Apolipoprotein E/Aβ Complex Accumulates in AD Cortical Synapses via apoE Receptors and Is Enhanced by APOE4

(2019) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

(2019) Frank J. Wolters et al.   NEUROLOGY

Hippocampal microvasculature changes in association with oxidative stress in Alzheimer's disease

(2018) Abhik Sen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shared pathological pathways of Alzheimer's disease with specific comorbidities: current perspectives and interventions

(2018) Christiane M. Nday et al.   JOURNAL OF NEUROCHEMISTRY

FAR2 is Associated with Kidney Disease in Mice and Humans

(2018) Grant Backer et al.   PHYSIOLOGICAL GENOMICS

Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

(2018) Masaki Tsuchiya et al.   Nature Communications

Oxidative and Nitrosative Modifications of Biliverdin Reductase-A in the Brain of Subjects with Alzheimer's Disease and Amnestic Mild Cognitive Impairment

(2018) Eugenio Barone et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Hemoglobin is Reduced in Alzheimer's Disease, Argyrophilic Grain Disease, Parkinson's Disease, and Dementia with Lewy Bodies

(2018) Isidro Ferrer et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease

(2018) D Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Placentation defects are highly prevalent in embryonic lethal mouse mutants

(2018) Vicente Perez-Garcia et al.   NATURE

Shotgun lipidomics in substantiating lipid peroxidation in redox biology: Methods and applications

(2017) Changfeng Hu et al.   Redox Biology

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34

(2016) Verónica Demicheli et al.   BIOCHEMISTRY

3-Nitrotyrosine quantification methods: Current concepts and future challenges

(2016) Dulce Teixeira et al.   BIOCHIMIE

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease

(2016) Masashi Asai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

APOE genotype and stress response - a mini review

(2016) Janina Dose et al.   Lipids in Health and Disease

New ATP8A2 gene mutations associated with a novel syndrome: encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy

(2016) Elena Martín-Hernández et al.   NEUROGENETICS

Clinical Relevance of Biomarkers of Oxidative Stress

(2015) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Potential hippocampal genes and pathways involved in Alzheimer’s disease: a bioinformatic analysis

(2015) L. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium

(2015) Katsumori Segawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Biomarkers of Necrosis in Xenografts Using Imaging Mass Spectrometry

(2015) Roberto Fernández et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

ATP Synthase Deficiency due to TMEM70 Mutation Leads to Ultrastructural Mitochondrial Degeneration and Is Amenable to Treatment

(2015) Anne K. Braczynski et al.   Biomed Research International

Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes

(2014) Raffaele Renella et al.   AMERICAN JOURNAL OF HEMATOLOGY

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

An anemia of Alzheimer's disease

(2014) N G Faux et al.   MOLECULAR PSYCHIATRY

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

(2014) Elina M. Sutinen et al.   Frontiers in Cellular Neuroscience

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

(2014) Ya-Ting Chang et al.   Biomed Research International

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

(2013) Valentina Gambino et al.   AGING CELL

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Gene-based GWAS and biological pathway analysis of the resilience of executive functioning

(2013) Shubhabrata Mukherjee et al.   Brain Imaging and Behavior

Cytochrome P450–mediated drug metabolism in the brain

(2013) Sharon Miksys et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Genetic Analysis of Mesangial Matrix Expansion in Aging Mice and Identification of Far2 as a Candidate Gene

(2013) G. A. Noordmans et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms

(2013) Lei Chen et al.   PLoS One

A Protocol for Quantifying Lipid Peroxidation in Cellular Systems by F2-Isoprostane Analysis

(2013) Christiaan F. Labuschagne et al.   PLoS One

Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53

(2012) Ido Goldstein et al.   CARCINOGENESIS

Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion

(2012) Onur Emre Onat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Blood markers of oxidative stress in Alzheimer's disease

(2012) Alice Skoumalová et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

(2012) Akihiko Nunomura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TMEM70: a mutational hot spot in nuclear ATP synthase deficiency with a pivotal role in complex V biogenesis

(2012) Alessandra Torraco et al.   NEUROGENETICS

Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

(2012) Xianjun Zhu et al.   PLoS Genetics

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

(2011) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Catalytic versus Inhibitory Promiscuity in Cytochrome P450s: Implications for Evolution of New Function

(2011) Robert S. Foti et al.   BIOCHEMISTRY

Circulating biomarkers of protein oxidation for Alzheimer disease: Expectations within limits

(2011) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress

(2011) Young-Ok Son et al.   BMB Reports

Plasmalogens the neglected regulatory and scavenging lipid species

(2011) Stefan Wallner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Screening for nuclear genetic defects in the ATP synthase-associated genes TMEM70, ATP12 and ATP5E in patients with 3-methylglutaconic aciduria

(2011) F Tort et al.   CLINICAL GENETICS

Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth

(2011) Mahmoud Hosseini et al.   Clinics

Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation

(2011) Xiulian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobin level in older persons and incident Alzheimer disease: Prospective cohort analysis

(2011) R. C. Shah et al.   NEUROLOGY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

(2010) Hafiz Mohmmad Abdul et al.   AGING CELL

Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

(2010) Ana C. Andreazza et al.   ARCHIVES OF GENERAL PSYCHIATRY

Expression and processing of the TMEM70 protein

(2010) Kateřina Hejzlarová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative damage to RNA: mechanisms, consequences, and diseases

(2010) Qiongman Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons

(2010) Jin Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine

(2010) You-Lin Tain et al.   FREE RADICAL BIOLOGY AND MEDICINE

Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes

(2010) María C. Serrano-Pérez et al.   GLIA

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery

(2010) Susanne Bryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

Circulating plasmalogen levels and Alzheimer Disease Assessment Scale–Cognitive scores in Alzheimer patients

(2010) Paul Wood   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Complex V TMEM70 deficiency results in mitochondrial nucleoid disorganization

(2010) Jessie M. Cameron et al.   MITOCHONDRION

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferentially Increased Nitration of α-Synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson’s Disease

(2009) Steven R. Danielson et al.   ANALYTICAL CHEMISTRY

Redox Proteomic Analysis of Carbonylated Brain Proteins in Mild Cognitive Impairment and Early Alzheimer's Disease

(2009) Rukhsana Sultana et al.   ANTIOXIDANTS & REDOX SIGNALING

Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain

(2009) Tero Tapiola et al.   ARCHIVES OF NEUROLOGY

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Asymmetrical Dimethylarginine Is Increased in Plasma and Decreased in Cerebrospinal Fluid of Patients with Alzheimer’s Disease

(2009) Sönke Arlt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

(2009) F. Dutheil et al.   DRUG METABOLISM AND DISPOSITION

Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis

(2009) Junghee Lee et al.   FASEB JOURNAL

Determining time of death: temperature-dependent postmortem changes in calcineurin A, MARCKS, CaMKII, and protein phosphatase 2A in mouse

(2009) Yekaterina O. Poloz et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: Role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway

(2009) Shan Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

(2009) Nicolas Abello et al.   JOURNAL OF PROTEOME RESEARCH

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

(2009) Akihiko Nunomura et al.   NEUROBIOLOGY OF DISEASE

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

(2009) Niresh Hariparsad et al.   NUCLEIC ACIDS RESEARCH

Importance of the lipid peroxidation biomarkers and methodological aspects FOR malondialdehyde quantification

(2009) Denise Grotto et al.   QUIMICA NOVA

Gene–environment interaction and oxidative stress in cardiovascular disease

(2008) Jeffrey W. Stephens et al.   ATHEROSCLEROSIS

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy

(2008) Alena Čížková et al.   NATURE GENETICS

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY