Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

(2019) Allison McIntosh et al.   BRAIN PATHOLOGY

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

(2019) Donald G Matthews et al.   Antioxidants

Heme Oxygenase 1 Induces Tau Oligomer Formation and Synapse Aberrations in Hippocampal Neurons

(2018) Zizhen Si et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluation of salivary heme oxygenase-1 as a potential biomarker of early Parkinson's disease

(2018) Wei Song et al.   MOVEMENT DISORDERS

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

(2018) Mariapaola Nitti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of Heme Oxygenase 1 Causes Cognitive Decline and Affects Pathways for Tauopathy in Mice

(2018) Dayong Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The sinister face of heme oxygenase-1 in brain aging and disease

(2018) Hyman M. Schipper et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway

(2018) Fabiana Morroni et al.   Aging and Disease

Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia

(2018) Kota Murohashi et al.   Canadian Respiratory Journal

HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide

(2018) Roberto Motterlini et al.   Redox Biology

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)

(2017) Ken Ling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Heme oxygenase-1 derived carbon monoxide suppresses Aβ1–42 toxicity in astrocytes

(2017) Nishani T Hettiarachchi et al.   Cell Death & Disease

Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

(2017) Faiz Ul Amin et al.   Scientific Reports

Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry

(2016) Tarek Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo

(2016) Aniket Nikam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine

(2016) Robert H. LeBlanc et al.   Journal of Neuroinflammation

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction

(2016) Yuping Li et al.   Journal of Neuroinflammation

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

The non-canonical functions of the heme oxygenases

(2016) Luca Vanella et al.   Oncotarget

Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer’s Disease

(2016) Hye Youn Sung et al.   PLoS One

Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice

(2015) Xiao-Ying Zhang et al.   Journal of Neuroinflammation

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

(2015) Taku Hatano et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Neurotherapeutic effects of novel HO-1 inhibitorsin vitroand in a transgenic mouse model of Alzheimer's disease

(2015) Ajay Gupta et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Early induction of oxidative stress in a mouse model of Alzheimer’s disease with heme oxygenase activity

(2014) SANLI XING et al.   Molecular Medicine Reports

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Heme oxygenase-1 protects against Alzheimer’s amyloid-β1-42-induced toxicity via carbon monoxide production

(2014) N Hettiarachchi et al.   Cell Death & Disease

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Heme oxygenase-1 and acute kidney injury

(2013) Karl A. Nath   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis

(2013) Paolo Fagone et al.   JOURNAL OF NEUROIMMUNOLOGY

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Upregulation of Heme Oxygenase-1 by Acteoside Through ERK and PI3 K/Akt Pathway Confer Neuroprotection Against Beta-Amyloid-Induced Neurotoxicity

(2011) Hong-Quan Wang et al.   NEUROTOXICITY RESEARCH

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Serum heme oxygenase-1 levels are increased in Parkinson’s disease but not in Alzheimer’s disease

(2009) I. Mateo et al.   ACTA NEUROLOGICA SCANDINAVICA

Suppression of Glial HO-1 Activitiy as a Potential Neurotherapeutic Intervention in AD

(2009) Hyman Schipper et al.   Current Alzheimer Research

Heme Oxygenase-1 as a Therapeutic Target in Neurodegenerative Diseases and Brain Infections

(2008) Antonio Cuadrado et al.   CURRENT PHARMACEUTICAL DESIGN