Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

(2021) Sophie G Kellaway et al.   Life Science Alliance

The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia

(2021) Guillermo Rodríguez-Hernández et al.   Frontiers in Cell and Developmental Biology

Role of HDACs in normal and malignant hematopoiesis

(2020) Pan Wang et al.   Molecular Cancer

Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation

(2020) Hyeseon Kang et al.   GENES & DEVELOPMENT

Conditional expression of HGAL leads to the development of diffuse large B-cell lymphoma in mice

(2020) Javier Raboso-Gallego et al.   BLOOD

Unravelling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

(2019) Antonio Agraz-Doblas et al.   HAEMATOLOGICA

Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation

(2019) Bethan Psaila et al.   BLOOD

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

(2019) Yan Liu et al.   Journal of Hematology & Oncology

HDAC Inhibitors in Acute Myeloid Leukemia

(2019) San José-Enériz et al.   Cancers

Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

(2019) Ekta Khattar et al.   Nature Communications

Loss of Pax5 Exploits Sca1-BCR-ABLp190Susceptibility to Confer the Metabolic Shift Essential for pB-ALL

(2018) Alberto Martín-Lorenzo et al.   CANCER RESEARCH

Lmo2 expression defines tumor cell identity during T‐cell leukemogenesis

(2018) Idoia García‐Ramírez et al.   EMBO JOURNAL

Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia

(2018) Carolina Vicente-Dueñas et al.   LEUKEMIA

RUNX1 and the endothelial origin of blood

(2018) Long Gao et al.   EXPERIMENTAL HEMATOLOGY

Subtype-specific regulatory network rewiring in acute myeloid leukemia

(2018) Salam A. Assi et al.   NATURE GENETICS

Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment

(2017) Ciaran Mooney et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

(2017) J A Cutler et al.   LEUKEMIA

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

(2017) Yu Liu et al.   NATURE GENETICS

microRNAs: important regulators of stem cells

(2017) Na Li et al.   Stem Cell Research & Therapy

On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver

(2016) Leonidas Benetatos et al.   ANNALS OF HEMATOLOGY

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

(2016) S. Nestorowa et al.   BLOOD

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

(2016) Anne-France Le Rolle et al.   Oncotarget

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation

(2015) O. N. Kuvardina et al.   BLOOD

Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates

(2015) Allen Wang et al.   Cell Stem Cell

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

(2015) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish

(2015) Xiaohui Liu et al.   Journal of Hematology & Oncology

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Molecular Pathogenesis of MALT Lymphoma

(2015) Katharina Troppan et al.   Gastroenterology Research and Practice

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

(2015) Rajneesh Pathania et al.   Nature Communications

LMO2 at 25 years: a paradigm of chromosomal translocation proteins

(2015) Jennifer Chambers et al.   Open Biology

HGAL localization to cell membrane regulates B-cell receptor signaling

(2014) X. Lu et al.   BLOOD

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

(2014) Jonah Riddell et al.   CELL

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

(2014) Amit Grover et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status

(2014) M Schmidt et al.   LEUKEMIA

The ets transcription factor Fli-1 in development, cancer and disease

(2014) Y Li et al.   ONCOGENE

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

(2013) Noushine Mossadegh-Keller et al.   NATURE

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

(2012) Monika Lichtinger et al.   EMBO JOURNAL

Epigenetics

(2012) James R. Tollervey et al.   Epigenetics

Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

(2012) C. Vicente-Duenas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia

(2012) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT–SSX2

(2011) C B Garcia et al.   ONCOGENE

MicroRNA Gene Regulatory Pathways in the Establishment and Maintenance of ESC Identity

(2010) Natalia J. Martinez et al.   Cell Stem Cell

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

(2009) Myriam Hemberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Synovial Sarcoma-Associated SYT-SSX2 Oncogene Antagonizes the Polycomb Complex Protein Bmi1

(2009) Roy Barco et al.   PLoS One

Hematopoietic Cytokines Can Instruct Lineage Choice

(2009) M. A. Rieger et al.   SCIENCE

Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus

(2008) K. Walter et al.   BLOOD

Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study group

(2008) T. Burmeister et al.   BLOOD

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Cancer induction by restriction of oncogene expression to the stem cell compartment

(2008) María Pérez-Caro et al.   EMBO JOURNAL