Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

(2016) Ekta Khattar et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of mutantTERTpromoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas

(2016) Yinghui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation

(2016) S. C. Ak nc lar et al.   Cancer Discovery

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

(2016) Chloé Lescale et al.   Cell Reports

Quantitative assessment of telomerase components in cancer cell lines

(2015) Semih Can Akıncılar et al.   FEBS LETTERS

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity

(2015) Cheryl M. Koh et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells

(2015) Andrea Björkman et al.   JOURNAL OF IMMUNOLOGY

Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia

(2015) CHENJIAO YAO et al.   Molecular Medicine Reports

Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

(2014) Chelsia Qiuxia Wang et al.   Cell Reports

Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity

(2013) Frank Yeung et al.   Cell Reports

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

(2012) N. Özlem Arat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells

(2012) Masahiro Kato et al.   TUMOR BIOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy

(2011) B. Y. S. Chuah et al.   ANNALS OF ONCOLOGY

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms

(2011) Yong Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dyskeratosis Congenita

(2011) I. Dokal   Hematology-American Society of Hematology Education Program

TRF2/RAP1 and DNA–PK mediate a double protection against joining at telomeric ends

(2010) Oriane Bombarde et al.   EMBO JOURNAL

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

Mammalian Rap1 widens its impact

(2010) Laure Crabbe et al.   NATURE CELL BIOLOGY

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

(2010) Hsiangling Teo et al.   NATURE CELL BIOLOGY

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer

(2009) J. Joshua Smith et al.   GASTROENTEROLOGY

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas

(2009) R. M. Nepal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes

(2008) Raghuvir S Tomar et al.   EMBO JOURNAL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics