Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision
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Title
Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision
Authors
Keywords
Receptor tyrosine kinase signaling, Tumor growth, Angiogenesis, Cancer therapies
Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 180, Issue -, Pages 739-752
Publisher
Elsevier BV
Online
2021-03-18
DOI
10.1016/j.ijbiomac.2021.03.075
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Note: Only part of the references are listed.- Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
- (2021) Xinya Gao et al. NATURE CELL BIOLOGY
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- (2021) Kalin Wilson et al. ONCOGENE
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- (2021) Xiong Shu et al. Stem Cell Research & Therapy
- mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors
- (2020) Yi-Ran Pan et al. Cell Communication and Signaling
- Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition
- (2020) Jenny Y. Xue et al. NATURE
- Pan-cancer analysis of whole genomes
- (2020) NATURE
- Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)
- (2020) Aaron C. Tan Thoracic Cancer
- Long noncoding RNA MALAT1 inhibits the apoptosis and autophagy of hepatocellular carcinoma cell by targeting the microRNA-146a/PI3K/Akt/mTOR axis
- (2020) Ningfu Peng et al. Cancer Cell International
- The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells
- (2020) Ina Nepstad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- EGFR blockade reverts resistance to KRAS G12C inhibition in colorectal cancer
- (2020) Vito Amodio et al. Cancer Discovery
- 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo
- (2020) Xueyin Zu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
- (2020) David S. Hong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
- (2020) Rong Wang et al. Nature Communications
- A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia
- (2020) Fabian Lang et al. BMC Pharmacology & Toxicology
- circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
- (2020) Wei Gao et al. Molecular Cancer
- Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer
- (2019) Ramona Graves-Deal et al. Oncotarget
- Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
- (2019) Carolina Caro-Vegas et al. mBio
- A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors
- (2019) Hiroshi Fukamachi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade
- (2019) Ying Zhu et al. GUT
- Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age – a multicenter retrospective study
- (2019) Afshin Saffari et al. Orphanet Journal of Rare Diseases
- PTEN expression and mutations in TSC1 , TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma
- (2019) Juan M. Roldan‐Romero et al. INTERNATIONAL JOURNAL OF CANCER
- The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens
- (2019) Yi-Ying Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
- (2019) Nan Jin et al. Nature Communications
- Fibroblast Growth Factor Receptor Signaling in Skin Cancers
- (2019) Malgorzata Czyz Cells
- Two novel TSC2 mutations in renal epithelioid angiomyolipoma sensitive to everolimus
- (2019) Tao Wang et al. CANCER BIOLOGY & THERAPY
- Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC
- (2019) Suresh S. Ramalingam et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
- (2019) Shanu Modi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regorafenib: A Review in Metastatic Colorectal Cancer
- (2018) Sohita Dhillon DRUGS
- Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic, and transcriptomic comparison
- (2018) Ina Nepstad et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Resistance to the Antiproliferative In Vitro Effect of PI3K-Akt-mTOR Inhibition in Primary Human Acute Myeloid Leukemia Cells Is Associated with Altered Cell Metabolism
- (2018) Ina Nepstad et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
- (2018) Shaocong Wu et al. Molecular Cancer
- Mechanisms of receptor tyrosine kinase activation in cancer
- (2018) Zhenfang Du et al. Molecular Cancer
- Advances in studies of tyrosine kinase inhibitors and their acquired resistance
- (2018) Qinlian Jiao et al. Molecular Cancer
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models
- (2018) Masahiro Matsuki et al. Cancer Medicine
- The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment
- (2018) Hanjiao Qin et al. PeerJ
- mTOR Pathways in Cancer and Autophagy
- (2018) Mathieu Paquette et al. Cancers
- Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors
- (2018) Stephen J H Dobbin et al. HEART
- Role of mTOR Signaling in Tumor Microenvironment: An Overview
- (2018) Fabiana Conciatori et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Brigatinib versus Crizotinib in ALK-Positive Non–Small-Cell Lung Cancer
- (2018) D. Ross Camidge et al. NEW ENGLAND JOURNAL OF MEDICINE
- Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors
- (2018) Pedro Miguel Lacal et al. PHARMACOLOGICAL RESEARCH
- Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis
- (2018) Ina Nepstad et al. Cancers
- HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib
- (2018) Y Wang et al. ANNALS OF ONCOLOGY
- MTORC1/2 inhibition as a therapeutic strategy for PIK3CA mutant cancers
- (2018) Stephanie L. Fricke et al. MOLECULAR CANCER THERAPEUTICS
- Azacytidine in combination with tyrosine kinase inhibitors induced durable responses in patients with advanced phase chronic myelogenous leukemia
- (2017) Mathilde Ruggiu et al. LEUKEMIA & LYMPHOMA
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- (2017) Roberta M. Manzat Saplacan et al. MEDIATORS OF INFLAMMATION
- Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma
- (2017) Jian-Yang Ao et al. MOLECULAR CANCER THERAPEUTICS
- Emerging functions of the EGFR in cancer
- (2017) Sara Sigismund et al. Molecular Oncology
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- (2017) Ahmet Zehir et al. NATURE MEDICINE
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- (2017) Shuo Cai et al. ONCOLOGY REPORTS
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- (2017) Alexandra C. Newton et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2017) Qiaowei Zheng et al. TUMOR BIOLOGY
- CSF-1R Inhibitor Development: Current Clinical Status
- (2017) Florent Peyraud et al. Current Oncology Reports
- Role of tumor microenvironment in tumorigenesis
- (2017) Maonan Wang et al. Journal of Cancer
- Phytochemicals and PI3K Inhibitors in Cancer—An Insight
- (2017) Vasanti Suvarna et al. Frontiers in Pharmacology
- Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy
- (2017) Seraina Faes et al. Cancers
- PIK3CAmutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab
- (2016) S. Loibl et al. ANNALS OF ONCOLOGY
- Expression and Clinical Significance of Sushi Domain-Containing Protein 3 (SUSD3) and Insulin-like Growth Factor-I Receptor (IGF-IR) in Breast Cancer
- (2016) Shuang Zhao et al. Asian Pacific Journal of Cancer Prevention
- Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and PDGF autocrine/paracrine loops
- (2016) Yang Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer
- (2016) Qing-Bai She et al. BMC CANCER
- Eph Receptor Tyrosine Kinases in Tumor Immunity
- (2016) Eileen Shiuan et al. CANCER RESEARCH
- New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer
- (2016) Sherry X. Yang et al. CANCER TREATMENT REVIEWS
- Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors
- (2016) E. Toska et al. CLINICAL CANCER RESEARCH
- Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton
- (2016) Andrei S Chagin CURRENT OPINION IN PHARMACOLOGY
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- The insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies
- (2016) Morteza Motallebnezhad et al. TUMOR BIOLOGY
- A photoactivatable Src homology 2 (SH2) domain
- (2016) X. Song et al. RSC Advances
- Roxarsone induces angiogenesis via PI3K/Akt signaling
- (2016) Yujing Wang et al. Cell and Bioscience
- Overexpression of EGFR Protein in Bruneian Lung Cancer Patients
- (2015) Yu Hao Han et al. Asian Pacific Journal of Cancer Prevention
- Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling
- (2015) Shaogang Sun et al. CANCER CELL
- Inhibition of the VEGF/VEGFR Pathway Improves Survival in Advanced Kidney Cancer: A Systematic Review and Meta-Analysis
- (2015) Roberto Iacovelli et al. CURRENT DRUG TARGETS
- The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis
- (2015) Roberto Ronca et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Regulation of Endothelial Cell Proliferation and Vascular Assembly through Distinct mTORC2 Signaling Pathways
- (2015) Shan Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- Phosphoinositide signaling in cancer: INPP4B Akt(s) out
- (2015) John F. Woolley et al. TRENDS IN MOLECULAR MEDICINE
- MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
- (2015) G S Choudhary et al. Cell Death & Disease
- PTEN mediates Notch-dependent stalk cell arrest in angiogenesis
- (2015) Helena Serra et al. Nature Communications
- cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
- (2015) Lukas Stanczuk et al. Cell Reports
- Targeting RTK Signaling Pathways in Cancer
- (2015) Tarik Regad Cancers
- Anti-Angiogenic Effect of Metformin in Mouse Oxygen-Induced Retinopathy Is Mediated by Reducing Levels of the Vascular Endothelial Growth Factor Receptor Flk-1
- (2015) Soo Geun Joe et al. PLoS One
- PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies
- (2015) Matthias Scheffler et al. Oncotarget
- AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation
- (2014) Elisa Boscolo et al. ANGIOGENESIS
- Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
- (2014) H J Lee et al. BRITISH JOURNAL OF CANCER
- Classes of phosphoinositide 3-kinases at a glance
- (2014) S. Jean et al. JOURNAL OF CELL SCIENCE
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
- (2014) K M Dodd et al. ONCOGENE
- Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
- (2014) Carolina Vera et al. Journal of Ovarian Research
- The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers
- (2014) Elisavet Paplomata et al. Therapeutic Advances in Medical Oncology
- Signaling of the ITK (Interleukin 2-inducible T Cell Kinase)-SYK (Spleen Tyrosine Kinase) Fusion Kinase Is Dependent on Adapter SLP-76 and on the Adapter Function of the Kinases SYK and ZAP70
- (2013) Alamdar Hussain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
- (2013) Adriana Soler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dual Phosphorylation of Btk by Akt/Protein Kinase B Provides Docking for 14-3-3ζ, Regulates Shuttling, and Attenuates both Tonic and Induced Signaling in B Cells
- (2013) Dara K. Mohammad et al. MOLECULAR AND CELLULAR BIOLOGY
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Development of PI3K inhibitors: lessons learned from early clinical trials
- (2013) Jordi Rodon et al. Nature Reviews Clinical Oncology
- Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review
- (2013) Monica Franciosi et al. PLoS One
- In vitro and ex vivo angiogenic effects of roxarsone on rat endothelial cells
- (2013) Jiaqiao Zhu et al. TOXICOLOGY LETTERS
- Repositioning metformin for cancer prevention and treatment
- (2013) Brendan J. Quinn et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Receptor Tyrosine Kinase-Mediated Angiogenesis
- (2013) M. Jeltsch et al. Cold Spring Harbor Perspectives in Biology
- VEGFR and Type-V RTK Activation and Signaling
- (2013) M. Shibuya Cold Spring Harbor Perspectives in Biology
- The Role of Epidermal Growth Factor Receptor in Cancer Metastasis and Microenvironment
- (2013) Takamitsu Sasaki et al. Biomed Research International
- Pathological Role of Serum- and Glucocorticoid-Regulated Kinase 1 in Adverse Ventricular Remodeling
- (2012) Saumya Das et al. CIRCULATION
- Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
- (2012) J. M. Spoerke et al. CLINICAL CANCER RESEARCH
- Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy
- (2012) Rossano Lattanzio et al. INTERNATIONAL JOURNAL OF CANCER
- Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
- (2012) M. Shibuya JOURNAL OF BIOCHEMISTRY
- Role of AKT isotypes in breast cancer
- (2012) Sunil Badve et al. JOURNAL OF PATHOLOGY
- Regulation of Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase (Btk) through a Novel SH3-Dependent Interaction with Ankyrin Repeat Domain 54 (ANKRD54)
- (2012) M. O. Gustafsson et al. MOLECULAR AND CELLULAR BIOLOGY
- The functions and regulation of the PTEN tumour suppressor
- (2012) Min Sup Song et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis
- (2011) C. Lieu et al. CLINICAL CANCER RESEARCH
- TEC family kinases in health and disease - loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK
- (2011) Alamdar Hussain et al. FEBS Journal
- Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer
- (2011) Todd W. Miller et al. JOURNAL OF CLINICAL ONCOLOGY
- Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study
- (2011) Kenneth J O'Byrne et al. LANCET ONCOLOGY
- Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
- (2010) R. Novosyadlyy et al. CANCER RESEARCH
- Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: Focus on Pi3K/AKT/eNOS pathway
- (2010) Bert R. Everaert et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways
- (2010) Rodrigue Romon et al. Molecular Cancer
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
- (2009) Kristy J. Gotink et al. ANGIOGENESIS
- Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein
- (2009) Alamdar Hussain et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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