Review
Biology
Ji-Sun Lee, Claire E. Tocheny, Leslie M. Shaw
Summary: This review provides an overview of the role of the IGF signaling pathway in breast cancer and discusses its potential as a therapeutic target. Dysregulation of IGF pathway components contributes to breast cancer risk and progression, and the pathway has also been implicated in resistance to current therapies. Unfortunately, targeting IGF signaling for breast cancer treatment has been unsuccessful so far due to adverse effects on normal glucose metabolism. However, recent discoveries offer hope for continued efforts in this area.
Review
Biochemistry & Molecular Biology
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Zhou Yu, Baoqiang Song
Summary: The article describes the expression changes and fibrosis-promoting effects of insulin-like growth factor 2 (IGF-2) in different tissues during fibrosis process.
Article
Oncology
Seyda Berk, Joseph A. M. J. L. Janssen, Peter M. van Koetsveld, Fadime Dogan, Naci Degerli, Servet Ozcan, Fahrettin Kelestimur, Leo J. Hofland
Summary: The effects of glucose, insulin, and IGF on the growth of colon cancer cells vary between early and late stages. Glucose plays a more significant role in stimulating proliferation in early stage cells, while growth factor-mediated stimulation becomes more pronounced in late stage cells. Strict glucose control may be crucial in controlling tumor growth in early stages, while inhibiting the endocrine actions of IGFs and insulin is more important in late stages of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Michael W. Lero, Leslie M. Shaw
Summary: This review underscores the significance of the IR/IGF-1R signaling pathway in cancer and its potential as a therapeutic target. Understanding the pathway's role in normal mammary gland function provides insight into its aberrations in breast cancer. However, efforts to target this pathway for cancer treatment are hindered by a lack of biomarkers and adverse effects on normal metabolism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Veronica Vella, Marika Giuliano, Maria Luisa Nicolosi, Maria Giovanna Majorana, Malgorzata Anna Marc, Maria Grazia Muoio, Andrea Morrione, Marcello Maggiolini, Rosamaria Lappano, Ernestina Marianna De Francesco, Antonino Belfiore
Summary: The study suggests that DDR1 may function as a novel regulator of breast cancer metabolism independently of IR/IGF1R stimulation, making it a potential target for therapy in breast cancer.
Review
Endocrinology & Metabolism
Leonie Rieger, Rosemary O'Connor
Summary: The internalization and localization of the IGF-1 receptor play crucial roles in cell signaling and biological processes, with different cell types and cell adhesion receptors regulating this process. Further study on how IGF-1R intracellular trafficking and compartmentalized signaling is controlled, particularly in cancer, is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomoko Okuyama, Mayu Kyohara, Yasuo Terauchi, Jun Shirakawa
Summary: IGFs mainly mediate long-term actions in cell fates, while insulin predominantly exerts its role on metabolic activities. The interactions between insulin receptor signaling and IGF-I receptor signaling in metabolism and cell fates are complicated, and the function of IGF-I in respective tissues remains insufficiently understood. Clarifying the precise roles of IGF-I signaling on metabolism separate from those of insulin signaling is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Review
Biochemistry & Molecular Biology
S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
Summary: The insulin-like growth factor signalling system plays a crucial role in the growth and development of fishes and shellfishes, serving as important biomarkers for assessing growth and nutritional status in aquaculture.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Review
Cell Biology
Joseph A. M. J. L. Janssen, Terry J. Smith
Summary: The insulin-like growth factor-I receptor (IGF-IR) plays an important role in the pathogenesis of TAO, and targeting this receptor with specific biologic agents may lead to a paradigm shift in the therapy of TAO.
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, Fumihiko Hakuno, Asako Takenaka
Summary: This study evaluates the contribution of protein nutrition and the GH/IGF-I system to body growth regulation. The results show that a reduction in serum EAA concentration hinders Igf1 transcription and decreases serum IGF-I levels. Restoring serum IGF-I levels through recombinant IGF-I infusion rescues body growth, indicating the importance of EAAs for animal growth.
Review
Food Science & Technology
Sima Ghaffari, Amin Abbasi, Mohammad Hossein Somi, Seyed Yaghoub Moaddab, Leila Nikniaz, Hossein Samadi Kafil, Hamed Ebrahimzadeh Leylabadlo
Summary: This article comprehensively reviews the features of Akkermansia muciniphila in terms of its function in host physiology and frequently utilized nutrition, indicating its potential as next-generation probiotics. However, certain issues need to be addressed before its extensive use as a probiotic.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Mahdi Asghari Ozma, Amin Abbasi, Mohammad Ahangarzadeh Rezaee, Hedayat Hosseini, Negin Hosseinzadeh, Sahar Sabahi, Seyyed Mohammad Ali Noori, Sama Sepordeh, Ehsaneh Khodadadi, Masoud Lahouty, Hossein Samadi Kafil
Summary: The medicinal characteristics of garlic's bioactive constituents have attracted scientific attention, and spectroscopic and chemometric techniques are important tools for fraud detection and food chain safety. Further studies are needed to explore the health advantages, potential toxicities, and safety profile of garlic's bioactive compounds.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Immunology
Masoud Ahangari Maleki, Aida Malek Mahdavi, Mohammad Sadegh Soltani-Zangbar, Mehdi Yousefi, Alireza Khabbazi
Summary: This study suggests that synbiotic supplementation has a beneficial effect on the IL-17/IL-23 pathway in patients with axial spondyloarthritis, but does not improve disease activity.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hadi Feizi, Mohammad Ahangarzadeh Rezaee, Reza Ghotaslou, Mohammad Sadrkabir, Farhad Jadidi-Niaragh, Pourya Gholizadeh, Sepehr Taghizadeh, Khudaverdi Ghanbarov, Mehdi Yousefi, Hossein Samadi Kafil
Summary: Colorectal cancer is influenced by genetic and environmental factors, including the gut microbiome. Gut microbiota alteration, particularly bacteriome alteration, is a common feature among CRC risk factors. The study suggests that gut microbial alterations could play a key role in promoting or contributing to CRC development as a cause or consequence.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
Ramin Pourakbari, Forough Parhizkar, Mohammad Sadegh Soltani-Zangbar, Parisa Samadi, Majid Zamani, Leili Aghebati-Maleki, Roza Motavalli, Ata Mahmoodpoor, Farhad Jadidi-Niaragh, Bahman Yousefi, Hossein Samadi Kafil, Mohammad Hojjat-Farsangi, Shahla Danaii, Mehdi Yousefi
Summary: This study identifies the impact of preeclampsia (PE) exosomes on the activity of Th17 and Treg cells and their related gene expression and cytokine profiles in healthy pregnant women. PE patients exhibited decreased Treg cell number and increased Th17 cells, while intervention with PE exosomes led to significant changes in gene expression and cytokine levels. These findings suggest a possible role of PE exosomes in the pathogenesis of PE.
REPRODUCTIVE SCIENCES
(2023)
Review
Cell Biology
Mojgan Esparvarinha, Sahar Madadi, Lida Aslanian-Kalkhoran, Hamid Nickho, Sanam Dolati, Helen Pia, Shahla Danaii, Simin Taghavi, Mehdi Yousefi
Summary: Pregnancy problems such as recurrent pregnancy loss, repeated implantation failure, and pre-eclampsia are common in reproductive ages and can be caused by genetic, immunological, and environmental factors, as well as infections. By identifying and eliminating the causes of abortion, the chances of successful pregnancy can be increased, but for cases with unknown causes, an imbalance in immune cell pattern may be present, leading to failed pregnancy. Therefore, treatment focuses on increasing tolerance rather than suppressing the maternal immune system.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Quantum Science & Technology
Taylor L. Patti, Omar Shehab, Khadijeh Najafi, Susanne F. Yelin
Summary: This article introduces a method that combines classical Markov chain Monte Carlo techniques with variational quantum algorithms, allowing the algorithm to converge to global minima and improve solution quality. The effectiveness of the technique is demonstrated through quantum circuit simulations and tests on large-scale quantum models.
QUANTUM SCIENCE AND TECHNOLOGY
(2023)
Article
Water Resources
Hamed Sabzchi-Dehkharghani, Hossein Samadi Kafil, Abolfazl Majnooni-Heris, Abbas Akbarzadeh, Rana Naderi-Ahranjani, Ahmad Fakherifard, Mohammad Mosaferi, Neda Gilani, Mojtaba Noury, Parisa Eydi, Sajjad Sayyari Sis, Nasimolzahra Toghyanian, Reza Yegani
Summary: Accurate monitoring of urban water resources is crucial during the COVID-19 pandemic, as demonstrated in this study investigating the amount of SARS-CoV-2 RNA in Tabriz urban water network in Iran. None of the water supply resources tested positive for SARS-COV-2 RNA, except for a sample from a well adjacent to an urban wastewater discharge point. Periodic sampling from wells and qanats is recommended during the pandemic to ensure safety.
SUSTAINABLE WATER RESOURCES MANAGEMENT
(2023)
Article
Chemistry, Analytical
Fatemeh Maleki, Habib Razmi, Mohammad-Reza Rashidi, Mehdi Yousefi, Soghra Ramazani, Marjan Ghorbani, Mohammad Hojjat-Farsangi, Kourosh Shahpasand
Summary: An electrochemical immunosensing platform was developed using a modified glassy carbon electrode and nanomaterials for the detection of receptor tyrosine kinase-orphan receptor-2 (ROR2). The modified nanomaterials exhibited good electrochemical behavior, mechanical strength, and sensitivity. Through various characterization methods, the designed immunosensor performance was validated and showed accurate detection of ROR2 with good selectivity, reproducibility, and stability in human plasma samples.
Article
Multidisciplinary Sciences
Forough Chakari-Khiavi, Arezoo Mirzaie, Balal Khalilzadeh, Hadi Yousefi, Rozita Abolhasan, Amin Kamrani, Ramin Pourakbari, Koorosh Shahpasand, Mehdi Yousefi, Mohammad-Reza Rashidi
Summary: This study developed a novel electrochemical immunosensor for the early-stage measurement of Alzheimer's disease. The immunosensor demonstrated selective and sensitive detection of the conformation of p-tau protein, with a low limit of detection and desired reproducibility and stability. Application of the immunosensor in the serum of AD patients validated its accuracy and feasibility.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Applied
Mahdi Asghari Ozma, Edris Nabizadeh, Mir Reza Valiollahzadeh, Jalil Rashedi, Behroz Mahdavi Poor, Vahid Asgharzadeh, Hossein Samadi Kafil, Ehsaneh Khodadadi, Zahra Taghinejad, Amin Abbasi, Ali Esmaeili, Mohammad Asgharzadeh
Summary: SARS-CoV-2 in China originated from animal to human transmission in late 2019. It quickly spread worldwide through human-to-human transmission, resulting in high mortality, especially among people with underlying diseases like hypertension. The virus binds to ACE2, a receptor that regulates the renin-angiotensin system and degrades vasoconstrictor angiotensin 2 (Ang II). Infection reduces ACE2 levels, leading to decreased Ang II degradation and increased complications associated with hypertension. Additionally, the anti-inflammatory effects of Ang1-7 are diminished. Lung damage and reduced oxygen delivery occur due to viral multiplication, inflammation, and edema of lung tissue. Careful management of hypertension patients can prevent infection and possibly reduce mortality with oxygen therapy and exogenous ACE2 supplements.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Genetics & Heredity
Peyvand Kashi, Farzaneh Pakdel, Mohammad Hossein Soroush Barhaghi, Mohammad Ahangarzadeh Rezaee, Sepehr Taghizadeh, Javid Sadeghi, Mehdi Yousefi, Reza Ghotaslou, Mohammad Asgharzadeh, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, the epidemiology of tuberculosis during the COVID-19 era was examined using MIRU-VNTR. The results showed that the pandemic had a direct effect on the transmission and diagnosis of tuberculosis. The decrease in diagnosis and clustering can be attributed to public controls, hygiene measures, and the use of masks. However, there may be a decrease in the focus on other respiratory infections during the pandemic. Further research on the co-infection of COVID-19 and tuberculosis, as well as the role of masks and sanitization in combating tuberculosis, is strongly recommended.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Ehsan Aminsobahni, Maryam Hosseini, Nasim Gholizadeh, Mohammad Sadegh Soltani-Zangbar, Golaleh Savari, Kimia Motlagh Asghari, Tannaz Pourlak, Mohammadali Zolfaghari, Forough Chakari-Khiavi, Roza Motavalli, Aref Chakari-Khiavi, Ali Akbar Shekarchi, Ata Mahmoodpoor, Javad Ahmadian Heris, Khadijeh Pouya, Amir Mehdizadeh, Zohreh Babalou, Mehdi Yousefi
Summary: Physiological changes during pregnancy increase the susceptibility to severe respiratory diseases, including COVID-19. This study investigated the effects of COVID-19 on T cell response and serum cytokine profile in pregnant women. The findings showed decreased lymphocyte count and poor T cell response, as well as elevated levels of inflammatory cytokines in infected pregnant women. Hypertension and metabolic changes were identified as potential prognostic factors in COVID-19 pregnant patients.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Applied
Mandi Asghari Ozma, Masoud Lahouty, Amin Abbasi, Mohammad Ahangarzadeh Rezaee, Hossein Samadi Kafil, Mohammad Asgharzadeh
Summary: Tuberculosis is a global health-threatening disease, with different lineages of Mycobacterium tuberculosis having varying transmission rates and pathogenicity. Rapid diagnosis and timely treatment are crucial in controlling the disease.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)