Microbial production, molecular modification, and practical application of l-Asparaginase: A review

Microbial l-asparaginase: purification, characterization and applications

(2020) Faizan Muneer et al.   ARCHIVES OF MICROBIOLOGY

Role of glutathione on acrylamide inhibition: Transformation products and mechanism

(2020) Yuchen Zhu et al.   FOOD CHEMISTRY

Recent Strategies and Applications for l-Asparaginase Confinement

(2020) João C. F. Nunes et al.   MOLECULES

Improvement of catalytic efficiency and thermal stability of l-asparaginase from Bacillus subtilis 168 through reducing the flexibility of the highly flexible loop at N-terminus

(2019) Yue Feng et al.   PROCESS BIOCHEMISTRY

Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry

(2019) Agnieszka Koszucka et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Bacterial l ‐asparaginases for cancer therapy: Current knowledge and future perspectives

(2019) Abdolmajid Ghasemian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thermal sensitivity as a quality control attribute for biotherapeutics: The L‐asparaginase case

(2019) Han Yao et al.   Drug Testing and Analysis

Crystallization and Preliminary X-ray Diffraction Study of a Mutant of L-Asparaginase from Wolinella succinogenes

(2019) V. I. Timofeev et al.   CRYSTALLOGRAPHY REPORTS

Molecular cloning, structural modeling and characterization of a novel glutaminase-free L-asparaginase from Cobetia amphilecti AMI6

(2019) Mohamed G. Farahat et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic LeukemiasIn Vivo

(2018) Hien Anh Nguyen et al.   CANCER RESEARCH

Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies

(2018) Noeman Ardalan et al.   MEDICAL HYPOTHESES

Marine microbial L-asparaginase: Biochemistry, molecular approaches and applications in tumor therapy and in food industry

(2018) Fatemeh Izadpanah Qeshmi et al.   MICROBIOLOGICAL RESEARCH

Improvement of l -asparaginase thermal stability by regulating enzyme kinetic and thermodynamic states

(2018) Yue Feng et al.   PROCESS BIOCHEMISTRY

Monitoring of asparagine depletion and anti-l-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial

(2018) Jérôme Paillassa et al.   Blood Cancer Journal

Low Bioavailability and High Immunogenicity of a New Brand of E. coli l -Asparaginase with Active Host Contaminating Proteins

(2018) Priscila Pini Zenatti et al.   EBioMedicine

Inhibitory effects of pomegranate flower extract and vitamin B3 on the formation of acrylamide during the donut making process

(2018) Mahin Heydari Ashkezari et al.   Journal of Food Measurement and Characterization

Biochemical characterization of a novel L-asparaginase from Paenibacillus barengoltzii being suitable for acrylamide reduction in potato chips and mooncakes

(2017) Ran Shi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acrylamide mitigation in French fries using native l-asparaginase from Aspergillus oryzae CCT 3940

(2017) Fernanda Furlan Gonçalves Dias et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B. subtilis WB600 through a combined strategy

(2016) Yue Feng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Amino acid residues adjacent to the catalytic cavity of tetramer l -asparaginase II contribute significantly to its catalytic efficiency and thermostability

(2016) Shuiqing Long et al.   ENZYME AND MICROBIAL TECHNOLOGY

The use of asparaginase to reduce acrylamide levels in cooked food

(2016) Fei Xu et al.   FOOD CHEMISTRY

Molecular expression of l -asparaginase gene from Nocardiopsis alba NIOT-VKMA08 in Escherichia coli : A prospective recombinant enzyme for leukaemia chemotherapy

(2016) Balakrishnan Meena et al.   GENE

A novel bacterial type II l -asparaginase and evaluation of its enzymatic acrylamide reduction in French fries

(2016) Zhibin Sun et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Design and Characterization ofErwinia Chrysanthemil-Asparaginase Variants with Diminished l-Glutaminase Activity

(2016) Hien Anh Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saccharomyces cerevisiae asparaginase II, a potential antileukemic drug: Purification and characterization of the enzyme expressed in Pichia pastoris

(2016) Luciana Facchinetti de Castro Girão et al.   PROTEIN EXPRESSION AND PURIFICATION

Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp.

(2016) Kruthi Doriya et al.   3 Biotech

Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp.

(2016) Kruthi Doriya et al.   3 Biotech

Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity

(2016) Iris Munhoz Costa et al.   Scientific Reports

A Comprehensive Review on l-Asparaginase and Its Applications

(2015) Tahira Batool et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

High yield expression of novel glutaminase free l-asparaginase II of Pectobacterium carotovorum MTCC 1428 in Bacillus subtilis WB800N

(2015) Sushma Chityala et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Therapeuticl-asparaginase: upstream, downstream and beyond

(2015) André Moreni Lopes et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Reduction of acrylamide level through blanching with treatment by an extremely thermostable l-asparaginase during French fries processing

(2015) Shaohua Zuo et al.   EXTREMOPHILES

Extracellular Production of Recombinant l-Asparaginase II in Escherichia coli: Medium Optimization Using Response Surface Methodology

(2015) Mohammad Bagher Ghoshoon et al.   International Journal of Peptide Research and Therapeutics

Asparaginase-associated toxicity in children with acute lymphoblastic leukemia

(2015) Nobuko Hijiya et al.   LEUKEMIA & LYMPHOMA

Cysteine alone or in combination with glycine simultaneously reduced the contents of acrylamide and hydroxymethylfurfural

(2015) Yueyu Zou et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Engineering of Helicobacter pylori L-Asparaginase: Characterization of Two Functionally Distinct Groups of Mutants

(2015) Maristella Maggi et al.   PLoS One

Recent research progress on microbial l-asparaginases

(2014) Shaohua Zuo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells

(2014) W. K. Chan et al.   BLOOD

Asparaginase in the treatment of non-ALL hematologic malignancies

(2014) Ashkan Emadi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cloning, expression, and characterization of thermophilicL-asparaginase fromThermococcus kodakarensisKOD1

(2014) Sung-Jun Hong et al.   JOURNAL OF BASIC MICROBIOLOGY

Refolding and purification of recombinant L-asparaginase from inclusion bodies of E. coli into active tetrameric protein

(2014) Arun K. Upadhyay et al.   Frontiers in Microbiology

Current developments in solid-state fermentation

(2013) Leya Thomas et al.   BIOCHEMICAL ENGINEERING JOURNAL

Engineering proteins for thermostability through rigidifying flexible sites

(2013) Haoran Yu et al.   BIOTECHNOLOGY ADVANCES

Recombinant Erwinia carotovora l-asparaginase II production in Escherichia coli fed-batch cultures

(2013) G. Roth et al.   BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING

Effect of surface charge alteration on stability of l-asparaginase II from Escherichia sp.

(2013) Jalaja Vidya et al.   ENZYME AND MICROBIAL TECHNOLOGY

Effect of vacuum roasting on acrylamide formation and reduction in coffee beans

(2013) Monica Anese et al.   FOOD CHEMISTRY

Mutations in Subunit Interface and B-cell Epitopes Improve Antileukemic Activities ofEscherichia coliAsparaginase-II

(2013) Ranjit Kumar Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient production of l-asparaginase from Bacillus licheniformis with low-glutaminase activity: Optimization, scale up and acrylamide degradation studies

(2012) Richi V. Mahajan et al.   BIORESOURCE TECHNOLOGY

Plant asparaginase-based asparagine biosensor for leukemia

(2012) Kuldeep Kumar et al.   Artificial Cells Nanomedicine and Biotechnology

Hyperthermophilic asparaginase mutants with enhanced substrate affinity and antineoplastic activity: structural insights on their mechanism of action

(2011) Saurabh Bansal et al.   FASEB JOURNAL

In silico Engineering of L-Asparaginase to Have Reduced Glutaminase Side Activity for Effective Treatment of Acute Lymphoblastic Leukemia

(2011) Ramya LN et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

(2010) M. N. Offman et al.   BLOOD

Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies

(2010) Edoardo Capuano et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

New Research Developments on Acrylamide: Analytical Chemistry, Formation Mechanism, and Mitigation Recipes

(2009) Yu Zhang et al.   CHEMICAL REVIEWS

Engineering thermal stability of l-asparaginase by in vitro directed evolution

(2009) Georgia A. Kotzia et al.   FEBS Journal

Acrylamide removal from heated foods

(2009) Monica Anese et al.   FOOD CHEMISTRY

Effect of L-asparaginase on acrylamide mitigation in a fried-dough pastry model

(2009) Kristína Kukurová et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Recent advances in solid-state fermentation

(2008) Reeta Rani Singhania et al.   BIOCHEMICAL ENGINEERING JOURNAL