Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies

Published 2018 View Full Article

Authors

Keywords

L-asparaginase, Escherichia coli, Glutaminase activity, Acute lymphocytic leukemia, Molecular dynamics, QMMM studies

Journal

MEDICAL HYPOTHESES

Volume 112, Issue -, Pages 7-17

Publisher

Elsevier BV

Online

2018-01-31

DOI

10.1016/j.mehy.2018.01.004

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