Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review

Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone

(2019) Bu Choi   MOLECULES

Development and Validation of a UHPLC-DAD Method for the Quantitative Analysis of Major Dihydrochalcone Glucosides from Thonningia sanguinea VAHL

(2019) Luca Pompermaier et al.   PLANTA MEDICA

3′-O-β-d-glucopyranosyl-α,4,2′,4′,6′-pentahydroxy-dihydrochalcone, from Bark of Eysenhardtia polystachya Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice

(2019) Rosa Pérez Gutierrez et al.   MOLECULES

Identification of Phytoconstituents in Leea indica (Burm. F.) Merr. Leaves by High Performance Liquid Chromatography Micro Time-of-Flight Mass Spectrometry

(2019) Deepika Singh et al.   MOLECULES

Hydrogenation of Halogenated 2′-Hydroxychalcones by Mycelia of Marine-Derived Fungus Penicillium raistrickii

(2019) Iara Lisboa de Matos et al.   MARINE BIOTECHNOLOGY

Eight new biflavonoids with lavandulyl units from the roots of Sophora flavescens and their inhibitory effect on PTP1B

(2019) Hai-Wei Yan et al.   BIOORGANIC CHEMISTRY

Atmospheric hydrogenation of α, β-unsaturated ketones catalyzed by highly efficient and recyclable Pd nanocatalyst

(2019) Pu Chen et al.   CATALYSIS COMMUNICATIONS

Synthesis of 4-C-β-D-Glucosylated Isoliquiritigenin and Analogues for Aldose Reductase Inhibition Studies.

(2019) Mannem Rajeswara Reddy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Impact of air-drying on polyphenol extractability from apple pomace

(2019) Simona Birtic et al.   FOOD CHEMISTRY

Production of high antioxidant activity flavonoid monoglucosides from citrus flavanone with immobilised α‐L‐rhamnosidase in one step

(2019) Aolu Liu et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

One-Pot Synthesis of O-Heterocycles or Aryl Ketones Using an InCl3/Et3SiH System by Switching the Solvent

(2019) Wenqiang Jia et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanisms of action of cytotoxic phenolic compounds from Glycyrrhiza iconica roots

(2019) Dicle Çevik et al.   PHYTOMEDICINE

Quantitation of dietary dihydrochalcones in Indian crabapple (Malus sikkimensis) using validated high-performance liquid chromatography

(2019) Shalini Dixit et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis

(2019) Ming Cheng et al.   Journal of Natural Medicines

Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration

(2019) Sithandiwe E. Mazibuko-Mbeje et al.   PLoS One

Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems

(2019) Bin Ding et al.   BMC Complementary and Alternative Medicine

Glucosylation of flavonoids and flavonoid glycosides by mutant dextransucrase from Lactobacillus reuteri TMW 1.106

(2019) Tizian Klingel et al.   CARBOHYDRATE RESEARCH

Effective Hydrogenation of 3-(2”-furyl)- and 3-(2”-thienyl)-1-(2’-hydroxyphenyl)-prop-2-en-1-one in Selected Yeast Cultures

(2019) Łużny et al.   MOLECULES

Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells

(2019) Yi-Hsuan Hsiao et al.   PHYTOMEDICINE

Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents

(2019) M. Irshad et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities

(2019) Hae Min So et al.   BIOORGANIC CHEMISTRY

Biocatalytic hydrogenation of the C=C bond in the enone unit of hydroxylated chalcones—process arising from cyanobacterial adaptations

(2018) Beata Żyszka-Haberecht et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Alpha, 2’-dihydroxy-4,4’-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy

(2018) Boshun Wan et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation

(2018) Ryuji Tsunekawa et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope

(2018) Shuwen Yin et al.   FEBS LETTERS

Monoamine oxidases inhibitors from Colvillea racemosa : Isolation, biological evaluation, and computational study

(2018) Enas I. Mohamed et al.   FITOTERAPIA

Genetic diversity of dihydrochalcone content in Malus germplasm

(2018) Benjamin L. Gutierrez et al.   GENETIC RESOURCES AND CROP EVOLUTION

Enzymatic production of natural sweetener trilobatin from citrus flavanone naringin using immobilised α-l -rhamnosidase as the catalyst

(2018) Lin Lei et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Development of dihydrochalcone-functionalized gold nanoparticles for augmented antineoplastic activity

(2018) Jason Payne et al.   International Journal of Nanomedicine

Antioxidant Structure–Activity Relationship Analysis of Five Dihydrochalcones

(2018) Xican Li et al.   MOLECULES

Synthesis of dihydroisorcordoin derivatives and their in vitro anti-oomycete activities

(2018) Iván Montenegro et al.   NATURAL PRODUCT RESEARCH

Multi-functional neuroprotective activity of neohesperidin dihydrochalcone: a novel scaffold for Alzheimer's disease therapeutics identified via drug repurposing screening

(2018) Sandipan Chakraborty et al.   NEW JOURNAL OF CHEMISTRY

Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity

(2018) Yibo Jin et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Zornioside, a dihydrochalcone C -glycoside, and other compounds from Zornia brasiliensis

(2018) Yuri M. Nascimento et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

The protective effect of phloretin in osteoarthritis: an in vitro and in vivo study

(2018) Wenhao Zheng et al.   Food & Function

Zornioside, a dihydrochalcone C -glycoside, and other compounds from Zornia brasiliensis

(2018) Yuri M. Nascimento et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Bioactive Phenolics of the Genus Artemisia (Asteraceae): HPLC-DAD-ESI-TQ-MS/MS Profile of the Siberian Species and Their Inhibitory Potential Against α-Amylase and α-Glucosidase

(2018) Daniil N. Olennikov et al.   Frontiers in Pharmacology

Chemical Constituents of Balanophora involucrata

(2018) Jing Feng et al.   CHEMISTRY OF NATURAL COMPOUNDS

Renal protective effects of aspalathin and nothofagin from rooibos ( Aspalathus linearis ) in a mouse model of sepsis

(2018) Sumin Yang et al.   Pharmacological Reports

Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria

(2018) H. Koudokpon et al.   Biomed Research International

Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis, Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway

(2018) Min Xu et al.   MEDICAL SCIENCE MONITOR

Nothofagin suppresses mast cell-mediated allergic inflammation

(2018) Byeong-Cheol Kang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Identification of Pinocembrin as an Anti-Glycation Agent and α-Glucosidase Inhibitor from Fingerroot (Boesenbergia rotunda): The Tentative Structure–Activity Relationship towards MG-Trapping Activity

(2018) Thammatee Potipiranun et al.   MOLECULES

Aspalathin ameliorates doxorubicin-induced oxidative stress in H9c2 cardiomyoblasts

(2018) Samukelisiwe C. Shabalala et al.   TOXICOLOGY IN VITRO

Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone, aspalathin

(2018) Chantelle Human et al.   FOOD CHEMISTRY

Structure-antioxidant capacity relationship of dihydrochalcone compounds in Malus

(2018) Zhengcao Xiao et al.   FOOD CHEMISTRY

Extraction, identification, and antioxidant and anticancer tests of seven dihydrochalcones from Malus ‘Red Splendor’ fruit

(2017) Zhengcao Xiao et al.   FOOD CHEMISTRY

Biosynthetic Pathway and Metabolic Engineering of Plant Dihydrochalcones

(2017) Mwafaq Ibdah et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation

(2017) Ana R. Jesus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties

(2017) Michael Eichenberger et al.   METABOLIC ENGINEERING

Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

(2017) Yu-Sheng Shi et al.   MOLECULES

The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model

(2017) Rabia Johnson et al.   MOLECULES

New prenylated dihydrochalcones from the leaves of Artocarpus elasticus

(2017) Mareena Daus et al.   Phytochemistry Letters

Phloretin induces apoptosis of human esophageal cancer via a mitochondria‑dependent pathway

(2017) Hongtao Duan et al.   Oncology Letters

Biotechnological methods for chalcone reduction using whole cells of Lactobacillus, Rhodococcus and Rhodotorula strains as a way to produce new derivatives

(2016) Monika Stompor et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

First Enantioselective Synthesis of Brosimacutins H and I

(2016) Ziping Ye et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Solubilities of Naringin Dihydrochalcone in Pure Solvents and Mixed Solvents at Different Temperatures

(2016) Ning Tang et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

Comparison of bioactive potential of cranberry fruit and fruit-based products versus leaves

(2016) Jan Oszmiański et al.   Journal of Functional Foods

Pharmacokinetics, Pharmacodynamics and Clinical Use of SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

(2015) André J. Scheen   CLINICAL PHARMACOKINETICS

Aspalathin and nothofagin from rooibos (Aspalathus linearis) inhibit endothelial protein C receptor shedding in vitro and in vivo

(2015) Soyoung Kwak et al.   FITOTERAPIA

Low calorie sweeteners in food and food supplements on the Italian market

(2015) Steven Janvier et al.   Food Additives & Contaminants Part B-Surveillance

Anti-inflammatory Effects of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) In Vitro and In Vivo

(2015) Wonhwa Lee et al.   INFLAMMATION

Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice

(2015) Qiong Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Preparative isolation, quantification and antioxidant activity of dihydrochalcones from Sweet Tea (Lithocarpus polystachyus Rehd.)

(2015) Yinshi Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense

(2015) Doudou Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Honeybush herbal teas (Cyclopia spp.) contribute to high levels of dietary exposure to xanthones, benzophenones, dihydrochalcones and other bioactive phenolics

(2015) Alexandra E. Schulze et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate

(2015) Sithandiwe E. Mazibuko et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dihydrochalcone Compounds Isolated from Crabapple Leaves Showed Anticancer Effects on Human Cancer Cell Lines

(2015) Xiaoxiao Qin et al.   MOLECULES

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

(2015) Priya J. Ghumatkar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Artocarpus altilis(Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells

(2015) Yoon Jung Jeon et al.   PHYTOTHERAPY RESEARCH

Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha

(2015) Tze Han Sum et al.   TETRAHEDRON

Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells

(2015) Tian-Tian Zhang et al.   Food & Function

Antithrombotic activities of aspalathin and nothofagin via inhibiting platelet aggregation and FIIa/FXa

(2014) Sae-Kwang Ku et al.   ARCHIVES OF PHARMACAL RESEARCH

Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.

(2014) Camilla R. Dal Picolo et al.   FITOTERAPIA

Biochemical and antimicrobial activity of phloretin and its glycosilated derivatives present in apple and kumquat

(2014) Davide Barreca et al.   FOOD CHEMISTRY

Towards the synthesis of glycosylated dihydrochalcone natural products using glycosyltransferase-catalysed cascade reactions

(2014) Alexander Gutmann et al.   GREEN CHEMISTRY

Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrassThalassodendron ciliatum(Forsk.) den Hartog

(2014) Magdy M.D. Mohammed et al.   NATURAL PRODUCT RESEARCH

Geranyl Dihydrochalcones from Artocarpus altilis and Their Antiausteric Activity

(2014) Mai Nguyen et al.   PLANTA MEDICA

Immunomodulation of phloretin by impairing dendritic cell activation and function

(2014) Chi-Chen Lin et al.   Food & Function

Anticholinesterase Activities Of Selected Polyphenols – A Short Report

(2014) Dominik Szwajgier   POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES

Rhodium(I)-Catalyzed Arylation of β-Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/ Conjugate Addition

(2013) Quanbin Jiang et al.   ADVANCED SYNTHESIS & CATALYSIS

Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro

(2013) Tomasz Tronina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phenylpropiophenone derivatives as potential anticancer agents: Synthesis, biological evaluation and quantitative structure–activity relationship study

(2013) Branka M. Ivković et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microbial synthesis of dihydrochalcones using Rhodococcus and Gordonia species

(2013) Monika Stompor et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum

(2013) Jariya Somsrisa et al.   MOLECULES

Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents

(2013) Madeline Simpson et al.   MOLECULES

Discovery of Dihydrochalcone as Potential Lead for Alzheimer’s Disease: In Silico and In Vitro Study

(2013) Man Hoang Viet et al.   PLoS One

Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications

(2012) Anna Baldisserotto et al.   MOLECULES

Two New C-benzylated Dihydrochalcone Derivatives from the Leaves of Melodorum siamensis

(2012) Uma Prawat et al.   PLANTA MEDICA

New antibacterial dihydrochalcone derivatives from buds of Populus balsamifera

(2012) Serge Lavoie et al.   TETRAHEDRON LETTERS

An efficient and heterogeneous recyclable palladium catalyst for chemoselective conjugate reduction of α,β-unsaturated carbonyls in aqueous medium

(2011) Dattatraya B. Bagal et al.   GREEN CHEMISTRY

Solubilities of Phloretin in 12 Solvents at Different Temperatures

(2011) Bingbo Li et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

(2011) Lindie Schloms et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Biotransformation of chalcones by the endophytic fungus Aspergillus flavus isolated from Paspalum maritimum trin

(2011) Marivaldo J. C Corrêa et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats

(2011) Mahmood Najafian et al.   MOLECULAR BIOLOGY REPORTS

Estrogenic and Antiestrogenic Activities of Phloridzin

(2010) Junzhi Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Microbial glucosylation of flavonols by Cunninghamella echinulata

(2010) Shunichi Miyakoshi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Efficient chemoselective biohydrogenation of 1,3-diaryl-2-propen-1-ones catalyzed by Saccharomyces cerevisiae yeasts in biphasic system

(2010) Vanessa Dutra Silva et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Inhibition of Oxidation of Aqueous Emulsions of Omega-3 Fatty Acids and Fish Oil by Phloretin and Phloridzin

(2010) H. Vasantha Rupasinghe et al.   MOLECULES

Chalcones and Dihydrochalcones Augment TRAIL-Mediated Apoptosis in Prostate Cancer Cells

(2010) Ewelina Szliszka et al.   MOLECULES

Phloridzin: Biosynthesis, distribution and physiological relevance in plants

(2010) Christian Gosch et al.   PHYTOCHEMISTRY

Cloning and heterologous expression of glycosyltransferases from Malus x domestica and Pyrus communis, which convert phloretin to phloretin 2′-O-glucoside (phloridzin)

(2010) Christian Gosch et al.   PLANT SCIENCE

Antioxidant Activity of the Dihydrochalcones Aspalathin and Nothofagin and Their Corresponding Flavones in Relation to Other Rooibos (Aspalathus linearis) Flavonoids, Epigallocatechin Gallate, and Trolox

(2009) Petra W. Snijman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery

(2009) Ajay Semalty et al.   JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

TheC-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans

(2009) Fraser L. Courts et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Influence of apple polyphenols on inflammatory gene expression

(2009) Mathias Jung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cross-coupling reaction of alcohols for carbon–carbon bond formation using pincer-type NHC/palladium catalysts

(2009) Osamu Kose et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Flavonoids of Tomatoes

(2008) Rune Slimestad et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbial transformations of flavanone by Aspergillus niger and Penicillium chermesinum cultures

(2008) Edyta Kostrzewa-Susłow et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside

(2008) Susanne Kreuz et al.   NUTRITION RESEARCH