Article
Pharmacology & Pharmacy
Yali Li, Liqun Wang, Qianyu Zhang, Li Tian, Cailing Gan, Hongyao Liu, Wenya Yin, Tinghong Ye
Summary: Blueberry juice can alleviate the pathological changes and collagen deposition in idiopathic pulmonary fibrosis by suppressing epithelial-mesenchymal transition and the TGF-beta 1/Smad signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sakura Fujiwara, Takeshi Izawa, Mutsuki Mori, Machi Atarashi, Jyoji Yamate, Mitsuru Kuwamura
Summary: Iron has been found to be involved in the development and progression of nonalcoholic fatty liver disease and dysmetabolic iron overload syndrome, but the specific role of iron in their pathogenesis remains unclear.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Summary: In this study, the effects of human adipose derived stem cells (hADSCs) on experimentally induced hepatic fibrosis and early cirrhosis in rats were evaluated. The results showed that treatment with hADSCs significantly improved liver functions and reduced hepatic fibrosis and early cirrhosis.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Xiao-Feng Chen, Shaoxiu Ji
Summary: Sorafenib exerts significant anti-fibrotic effects in fibrotic rats through mediating crotonylation-regulated enzymes and protein crotonylation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Cui Zhu, Xiaoyan Nie, Zhentao He, Taidi Xiong, Yaojie Li, Yinshan Bai, Huihua Zhang
Summary: This study investigated the protective effect of resveratrol (RES) on the hepatic antioxidant status and systemic inflammation in yellow-feathered broilers challenged with lipopolysaccharide (LPS). The results showed that dietary RES supplementation could improve the antioxidant capacity and attenuate LPS-induced inflammation in the liver of yellow-feathered broilers.
Article
Chemistry, Multidisciplinary
Danielle Galdino de Souza, Debora Silva Santos, Karina Smidt Simon, Jose Athayde Vasconcelos Morais, Luisa Coutinho Coelho, Thyago Jose Arruda Pacheco, Ricardo Bentes Azevedo, Anamelia Lorenzetti Bocca, Cesar Augusto Melo-Silva, Joao Paulo Figueiro Longo
Summary: Diets rich in omega-3 fatty acids, such as fish oil, can modulate inflammatory responses and cell membrane composition. This study found that the use of lipid nanoemulsion containing fish oil significantly reduced fibrotic progression and inflammation in an experimental model of pulmonary fibrosis.
Article
Food Science & Technology
Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga-Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka
Summary: Dietary supplementation with a synbiotic containing okara and Bacillus coagulans lilac-01 can improve hepatic lipid accumulation induced by cholic acid, by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Bin Li, Haikun Li, Baoge Song, Jinlong Tian, Ningxuan Gao, Ye Zhang, Chi Shu
Summary: Blueberry juice fermented with probiotics contains more active substances and has increased antioxidant capacity. The fermentation process increases the relative content of anthocyanins and polyphenols in the blueberry juice. Both blueberry juice and fermented blueberry juice can attenuate gastric injuries, suppress oxidative stress and inflammation through the inhibition of NF-κB pathway and induction of PGE2 level. The protective effects of fermented blueberry juice are significantly stronger than those of blueberry juice. This study demonstrates that blueberry juice can be used as a protective strategy against alcohol-induced gastric injuries, and the effects can be strengthened by fermentation with probiotics.
Article
Immunology
Lan Li, Dongqi Cheng, Xingxing An, Guangneng Liao, Ling Zhong, Jingping Liu, Younan Chen, Yujia Yuan, Yanrong Lu
Summary: The study demonstrated that MSCs treatment could reduce elevated levels of uric acid and improve kidney function in hyperuricemic nephropathy rat models. In vitro experiments also showed that MSCs could protect against uric acid-induced cell injury. These findings suggest that MSCs therapy may be a potential treatment for hyperuricemia-related renal diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Zohurul Islam, Jahidul Islam, Selim Reza Tony, Adiba Anjum, Rafia Ferdous, Apurba Kumar Roy, Shakhawoat Hossain, Kazi Abdus Salam, Farjana Nikkon, Khaled Hossain, Zahangir Alam Saud
Summary: Arsenic poisoning has caused a serious environmental catastrophe in Bangladesh, and this study found that mulberry leaves juice can protect against arsenic-induced neurobehavioral and hepatic dysfunctions.
FOOD SCIENCE & NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Kevin O'Gallagher, Sarah Borg Cardona, Callum Hill, Ali Al-Saedi, Fawzia Shahed, Christopher N. Floyd, Karen McNeill, Charlotte E. Mills, Andrew J. Webb
Summary: This study found that grapefruit juice enhanced the effect of beetroot juice on lowering systolic blood pressure and pulse pressure, despite decreasing plasma nitrite levels. This suggests more complex mechanisms at play and potential for maximizing the clinical benefits of dietary nitrate in targeting isolated systolic hypertension.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Immunology
Azusa Kobayashi, Ayaka Ito, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi-Takamura, Shoichi Maruyama, Takayoshi Suganami
Summary: Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with autoimmune diseases, but the mechanism by which fatty acid composition affects autoimmune responses remains unclear. Dietary supplementation of EPA has been found to ameliorate lupus manifestations by remodeling B cell membranes, preventing differentiation into autoantibody-producing plasma cells. These results highlight a potential therapeutic benefit of EPA supplementation for lupus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Floris Haijer, Shiva Koets-Shajari, Janette Heegsma, Sandra Serna-Salas, Tjasso Blokzijl, Manon Buist-Homan, Han Moshage, Klaas Nico Faber
Summary: Liver fibrosis is caused by excessive proliferation and collagen production by hepatic stellate cells (HSCs) due to chronic liver injury. Hydroxyurea, an anti-proliferative drug, showed inhibitory effects on HSC proliferation and fibrosis development in both in vitro and in vivo experiments. This study provides evidence for the therapeutic potential of hydroxyurea in treating liver fibrosis.
Article
Medicine, Research & Experimental
Tomohiro Shigematsu, Soichiro Tajima, Rao Fu, Mengyu Zhang, Yuuka Itoyama, Akihiro Tsuchimoto, Nobuaki Egashira, Ichiro Ieiri
Summary: Research shows that everolimus attenuates tacrolimus-induced renal interstitial fibrosis through the inhibition of mTOR signaling. This finding provides guidance for the concomitant use of everolimus and tacrolimus in clinical practice.
Article
Fisheries
Hui Liang, Yadong Xie, Yu Li, Mingxu Xie, Ming Li, Wei Zhou, Jie Chen, Zhen Zhang, Yalin Yang, Chao Ran, Zhigang Zhou
Summary: This study found that mannan can enhance the resistance of zebrafish to SVCV, inhibiting the replication and adsorption of the virus. Additionally, mannan alters the structure of zebrafish's intestinal microbiota, which also contributes to the antiviral effect of mannan.
