Fluorine‐Labelled Spiro[3.3]heptane‐Derived Building Blocks: Is Single Fluorine the Best?

Updating the CSIC Reaction (2003–2020)

(2021) Alexey V. Dobrydnev et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico‐Chemical Properties

(2021) Andrii Fedyk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings

(2020) David O'Hagan   CHEMISTRY-A EUROPEAN JOURNAL

What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein

(2020) Hannah Welte et al.   Scientific Reports

Development of a Scalable Synthesis of trans-4-Fluorocyclohexylamine via Directed Hydrogenation

(2020) Joyce C. Leung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

N–C Axially Chiral Compounds with an ortho-Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction

(2019) Asumi Iida et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorine‐Containing Drugs Approved by the FDA in 2018

(2019) Haibo Mei et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Fluorine gauche Effect and a Comparison with Other Halogens in 2-Halofluoroethanes and 2-Haloethanols

(2019) Francisco A. Martins et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Following Ramachandran 2: exit vector plot (EVP) analysis of disubstituted saturated rings

(2018) Oleksandr O. Grygorenko et al.   NEW JOURNAL OF CHEMISTRY

Bestmann-Ohira Reagent: A Convenient and Promising Reagent in the Chemical World

(2018) Manoj Dhameja et al.   Asian Journal of Organic Chemistry

Delivering Structural Information on the Polar Face of Membrane-Active Peptides: 19 F-NMR Labels with a Cationic Side Chain

(2016) Oleg M. Michurin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State 19 F NMR Spectroscopy

(2016) Serhii O. Kokhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

(2016) Ignacio Colomer et al.   CHEMICAL COMMUNICATIONS

Charting Biologically Relevant Spirocyclic Compound Space

(2016) Gerhard Müller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

(2016) Minghao Feng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The utilization of spirocyclic scaffolds in novel drug discovery

(2016) Ya-Jun Zheng et al.   Expert Opinion on Drug Discovery

The Fluorine Gauche Effect: A Brief History

(2016) Christian Thiehoff et al.   ISRAEL JOURNAL OF CHEMISTRY

Synthesis of fluorinated building blocks based on spiro[3.3]heptane scaffold

(2016) Anton V. Chernykh et al.   TETRAHEDRON

Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

(2016) Andriy V. Tymtsunik et al.   RSC Advances

Following Ramachandran: exit vector plots (EVP) as a tool to navigate chemical space covered by 3D bifunctional scaffolds. The case of cycloalkanes

(2016) Oleksandr O. Grygorenko et al.   RSC Advances

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

(2015) Keith E. Arntson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structural Analysis of Angular Monoprotected Diamines Based on Spiro[3.3]heptane Scaffold

(2015) Anton V. Chernykh et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent Developments in the Suzuki-Miyaura Reaction: 2010–2014

(2015) Irene Maluenda et al.   MOLECULES

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conformational restriction: an effective tactic in 'follow-on'-based drug discovery

(2014) Zengjun Fang et al.   Future Medicinal Chemistry

Design and Synthesis of Novel 19F-Amino Acid: A Promising 19F NMR Label for Peptide Studies

(2014) Dmytro Bandak et al.   ORGANIC LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Focused enumeration and assessing the structural diversity of scaffold libraries: conformationally restricted bicyclic secondary diamines

(2012) Oleksandr O. Grygorenko et al.   MOLECULAR DIVERSITY

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

(2011) Johannes A. Burkhard et al.   ORGANIC LETTERS

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A DFT study on the origin of the fluorine gauche effect in substituted fluoroethanes

(2010) David Y. Buissonneaud et al.   TETRAHEDRON

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY