A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool
Authors
Keywords
-
Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 45, Pages 7209-7212
Publisher
Royal Society of Chemistry (RSC)
Online
2016-05-05
DOI
10.1039/c6cc03244c
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library
- (2015) Monique Lüthy et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
- (2015) Daniel J. Foley et al. CHEMICAL COMMUNICATIONS
- A unified lead-oriented synthesis of over fifty molecular scaffolds
- (2015) Richard G. Doveston et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- The convergent total synthesis of cytotoxic homospisulosine and its 3-epi-analogue
- (2015) Kvetoslava Stanková et al. TETRAHEDRON-ASYMMETRY
- A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds
- (2014) Thomas James et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides
- (2014) Sergey V. Ryabukhin et al. ACS Combinatorial Science
- A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds
- (2013) Paul MacLellan et al. CHEMICAL COMMUNICATIONS
- Towards the realisation of lead-oriented synthesis
- (2013) Richard Doveston et al. DRUG DISCOVERY TODAY
- Modular, Gold-Catalyzed Approach to the Synthesis of Lead-like Piperazine Scaffolds
- (2013) Thomas James et al. ORGANIC LETTERS
- Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
- (2012) Alan Nadin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Plane of Best Fit: A Novel Method to Characterize the Three-Dimensionality of Molecules
- (2012) Nicholas C. Firth et al. Journal of Chemical Information and Modeling
- ZINC: A Free Tool to Discover Chemistry for Biology
- (2012) John J. Irwin et al. Journal of Chemical Information and Modeling
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway
- (2011) Diane Robbins et al. Chemical Science
- Molecular obesity, potency and other addictions in drug discovery
- (2011) Michael M. Hann MedChemComm
- Drug- and Lead-likeness, Target Class, and Molecular Diversity Analysis of 7.9 Million Commercially Available Organic Compounds Provided by 29 Suppliers
- (2010) Alexander Chuprina et al. Journal of Chemical Information and Modeling
- An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs
- (2010) Emanuele Perola JOURNAL OF MEDICINAL CHEMISTRY
- Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
- (2009) Michael J. Waring BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
- (2009) Timothy J. Ritchie et al. DRUG DISCOVERY TODAY
- Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
- (2009) Frank Lovering et al. JOURNAL OF MEDICINAL CHEMISTRY
- The influence of lead discovery strategies on the properties of drug candidates
- (2009) György M. Keserü et al. NATURE REVIEWS DRUG DISCOVERY
- Mild Conditions for Pd-Catalyzed Carboamination ofN-Protected Hex-4-enylamines and 1-, 3-, and 4-Substituted Pent-4-enylamines. Scope, Limitations, and Mechanism of Pyrrolidine Formation
- (2008) Myra Beaudoin Bertrand et al. JOURNAL OF ORGANIC CHEMISTRY
- Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry
- (2008) Alan H. Lipkus et al. JOURNAL OF ORGANIC CHEMISTRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started