The utilization of spirocyclic scaffolds in novel drug discovery

Robenidine Analogues as Gram-Positive Antibacterial Agents

(2016) Rebecca J. Abraham et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)

(2015) Alessio Lodola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

(2015) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of rolapitant in chemotherapy-induced emesis

(2015) Ian Olver   LANCET ONCOLOGY

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

(2015) Santhosh F. Neelamkavil et al.   ACS Medicinal Chemistry Letters

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR405838: An Optimized Inhibitor of MDM2-p53 Interaction That Induces Complete and Durable Tumor Regression

(2014) S. Wang et al.   CANCER RESEARCH

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

(2014) Erick M. Carreira et al.   CHEMICAL REVIEWS

Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine

(2014) Ian M. Bell   JOURNAL OF MEDICINAL CHEMISTRY

8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

(2014) Allen A. Thomas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

(2014) Thomas A. Dineen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Jing Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection

(2013) John O. Link et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Tofogliflozin, a Novel C-Arylglucoside with an O-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

(2012) Yoshihito Ohtake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain

(2011) Marvin J. Meyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine

(2010) Steffen Fischer et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Heteroaromatic Rings of the Future

(2009) William R. Pitt et al.   JOURNAL OF MEDICINAL CHEMISTRY