The expanding world of tissue‐resident macrophages

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

(2021) Alexandra C. McQuattie-Pimentel et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages inhibit and enhance endometriosis depending on their origin

(2021) Chloe Hogg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic Analysis of Rat Macrophages

(2021) Clare Pridans et al.   Frontiers in Immunology

Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection

(2021) Bibo Zhu et al.   IMMUNITY

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

(2021) P. A. Louwe et al.   Nature Communications

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury

(2021) Hengwei Jin et al.   Nature Communications

Dynamics of human monocytes and airway macrophages during healthy aging and after transplant

(2020) Adam J. Byrne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer

(2020) Min Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis

(2020) Sang Hun Lee et al.   Science Immunology

Determinants of Resident Tissue Macrophage Identity and Function

(2020) Camille Blériot et al.   IMMUNITY

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

(2020) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

(2020) C. C. Bain et al.   Science Immunology

Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection

(2020) Braedon McDonald et al.   Cell Host & Microbe

Commensal-driven immune zonation of the liver promotes host defence

(2020) Anita Gola et al.   NATURE

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

(2020) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity

(2019) Rejane Rua et al.   NATURE IMMUNOLOGY

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity

(2019) Nan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

(2019) Nicholas N. Jarjour et al.   NATURE IMMUNOLOGY

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

(2019) Matthew B. Buechler et al.   IMMUNITY

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury

(2019) Ivana R. Ferrer et al.   Science Immunology

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signaling in monocyte-derived alveolar macrophages

(2019) Nikita Joshi et al.   EUROPEAN RESPIRATORY JOURNAL

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Regulation of mononuclear phagocyte function by the microbiota at mucosal sites

(2019) Nicholas A. Scott et al.   IMMUNOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

(2018) Anna Baranska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System

(2018) Catherine A. Hawley et al.   JOURNAL OF IMMUNOLOGY

Neutrophil and macrophage cell surface CSF-1 shed by ADAM17 drives mouse macrophage proliferation in acute and chronic inflammation

(2018) Jingjing Tang et al.   MOLECULAR AND CELLULAR BIOLOGY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

(2018) Irene Soncin et al.   Nature Communications

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

(2018) Sharon M Campbell et al.   eLife

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

(2018) Charlotte L. Scott et al.   IMMUNITY

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

(2018) David E. Sanin et al.   IMMUNITY

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

(2018) Harald Lund et al.   Nature Communications

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

(2018) Anat Shemer et al.   Nature Communications

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells

(2017) Allison W. Roberts et al.   IMMUNITY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

(2017) Shruti Naik et al.   NATURE

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2

(2017) Justine Newson et al.   Cell Reports

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

(2017) Dominik Rückerl et al.   PLoS Pathogens

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha

(2016) Lucy H. Jackson-Jones et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

(2015) S. L. Gibbings et al.   BLOOD

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas

(2015) Naomi Van Gassen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

(2015) James C. Cronk et al.   IMMUNITY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

(2014) U. M. Gundra et al.   BLOOD

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage proliferation, provenance, and plasticity in macroparasite infection

(2014) Dominik Rückerl et al.   IMMUNOLOGICAL REVIEWS

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Homeostasis in the mononuclear phagocyte system

(2014) Stephen J. Jenkins et al.   TRENDS IN IMMUNOLOGY

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Multicolor fate mapping of Langerhans cell homeostasis

(2013) Clément Ghigo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

(2013) Luke C. Davies et al.   Nature Communications

Induction of IL-4R -dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

(2012) D. Ruckerl et al.   BLOOD

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

(2011) Elisa Tagliani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation

(2010) J. D. Milner et al.   BLOOD

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

(2009) K. J. Mylonas et al.   JOURNAL OF IMMUNOLOGY

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

(2008) Arnaud Didierlaurent et al.   JOURNAL OF EXPERIMENTAL MEDICINE