Targeting mutant p53 in cancer: a long road to precision therapy

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex

(2016) F Garibaldi et al.   ONCOGENE

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships

(2015) Fiamma Mantovani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer

(2015) Zhongwu Li et al.   Molecular Oncology

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4

(2015) Alla Polotskaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

PML tumour suppression and beyond: Therapeutic implications

(2014) Cristina Gamell et al.   FEBS LETTERS

Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

(2014) Thuy-Ai Nguyen et al.   HUMAN MUTATION

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients

(2013) F. Ganci et al.   ANNALS OF ONCOLOGY

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

(2013) Jacqueline L.Y. Chee et al.   CELL CYCLE

Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment

(2013) R. M. Connolly et al.   CLINICAL CANCER RESEARCH

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

(2013) Patricia A. J. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Increased Oxidative Metabolism in the Li–Fraumeni Syndrome

(2013) Ping-Yuan Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disarming mutant p53 oncogenic function

(2013) Javier E. Girardini et al.   PHARMACOLOGICAL RESEARCH

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

(2013) J. Zhuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

(2012) Eyal Kalo et al.   JOURNAL OF CELL SCIENCE

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

Wild-type and mutant p53 proteins interact with mitochondrial caspase-3

(2011) Amanda K. Frank et al.   CANCER BIOLOGY & THERAPY

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Multiple Stress Signals Activate Mutant p53 In Vivo

(2011) Y.-A. Suh et al.   CANCER RESEARCH

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Metformin, diet and breast cancer: An avenue for chemoprevention

(2011) Paola Muti et al.   CELL CYCLE

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A common gain of function of p53 cancer mutants in inducing genetic instability

(2009) D P Liu et al.   ONCOGENE

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants

(2008) A. Restle et al.   NUCLEIC ACIDS RESEARCH