PML tumour suppression and beyond: Therapeutic implications

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

(2013) Sue Haupt et al.   CELL CYCLE

Reprogramming and genome integrity: role of non-homologous end joining

(2013) P Salomoni   CELL DEATH AND DIFFERENTIATION

New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers

(2013) Kamil Wolyniec et al.   Frontiers in Oncology

PML: Not all about Tumor Suppression

(2013) Natalia Martin-Martin et al.   Frontiers in Oncology

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

(2012) K. Wolyniec et al.   BLOOD

The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA

(2012) A. Rabellino et al.   CANCER RESEARCH

PML regulates PER2 nuclear localization and circadian function

(2012) Takao Miki et al.   EMBO JOURNAL

Acute promyelocytic leukemia, arsenic, and PML bodies

(2012) Hugues de Thé et al.   JOURNAL OF CELL BIOLOGY

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks

(2012) Rebecca Ullmann et al.   MOLECULAR CELL

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

(2012) D Guan et al.   ONCOGENE

BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

(2012) Q Yang et al.   ONCOGENE

Role of the promyelocytic leukaemia protein in cell death regulation

(2012) P Salomoni et al.   Cell Death & Disease

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs

(2011) L Y Peche et al.   CELL DEATH AND DIFFERENTIATION

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

Development of Improved PPARβ/δ Inhibitors

(2011) Philipp M. Toth et al.   ChemMedChem

The nuclear bodies inside out: PML conquers the cytoplasm

(2011) Arkaitz Carracedo et al.   CURRENT OPINION IN CELL BIOLOGY

Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover

(2011) Jun Hee Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Protein Is Targeted by Arsenic for Degradation and Plays a Role in Arsenic-mediated Growth Suppression

(2011) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic trioxide — An old drug rediscovered

(2010) Ashkan Emadi et al.   BLOOD REVIEWS

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

(2010) Qingkai Yang et al.   CANCER CELL

SIRT1 stabilizes PML promoting its sumoylation

(2010) M Campagna et al.   CELL DEATH AND DIFFERENTIATION

Promyelocytic Leukemia Protein Controls Cell Migration in Response to Hydrogen Peroxide and Insulin-like Growth Factor-1

(2010) Erin L. Reineke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistance to Rabies Virus Infection Conferred by the PMLIV Isoform

(2010) Danielle Blondel et al.   JOURNAL OF VIROLOGY

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

PML-IV functions as a negative regulator of telomerase by interacting with TERT

(2009) W. Oh et al.   JOURNAL OF CELL SCIENCE

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Breast Cancer Molecular Subtypes in Patients With Locally Advanced Disease: Impact on Prognosis, Patterns of Recurrence, and Response to Therapy

(2009) Kathryn E. Huber et al.   SEMINARS IN RADIATION ONCOLOGY

New insights into the role of PML in tumour suppression

(2008) P Salomoni et al.   CELL RESEARCH

Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-β signalling

(2008) Nourdine Faresse et al.   EMBO JOURNAL

Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis

(2008) Fumihiko Hayakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of component exchange at PML nuclear bodies

(2008) S. Weidtkamp-Peters et al.   JOURNAL OF CELL SCIENCE

Histone Deacetylase 7 Promotes PML Sumoylation and Is Essential for PML Nuclear Body Formation

(2008) C. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

(2008) E Gresko et al.   ONCOGENE

PML enhances the regulation of p53 by CK1 in response to DNA damage

(2008) O Alsheich-Bartok et al.   ONCOGENE