Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth

(2016) D. M. Beauvais et al.   CANCER RESEARCH

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs

(2016) Ekaterina Petrovich et al.   FASEB JOURNAL

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology

(2016) Liliana Schaefer et al.   FEBS Journal

Syndecans - key regulators of cell signaling and biological functions

(2016) Nikolaos A. Afratis et al.   FEBS Journal

Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases

(2016) Silvia Rivara et al.   Future Medicinal Chemistry

An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches

(2016) Mayumi Sue et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype

(2016) Vishnu C. Ramani et al.   MATRIX BIOLOGY

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins

(2016) O Jung et al.   Oncogenesis

Function from within: Autophagy induction by HPSE/heparanase—new possibilities for intervention

(2015) Neta Ilan et al.   Autophagy

Syntenin and syndecan in the biogenesis of exosomes

(2015) Véronique Friand et al.   BIOLOGY OF THE CELL

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

(2015) C. Larrue et al.   BLOOD

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy

(2015) Anna Shteingauz et al.   CANCER RESEARCH

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

(2015) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains

(2015) Haiyao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental evidence of heparanase, Hsp70 and NF-κB gene expression on the response of anti-inflammatory drugs in TNBS-induced colonic inflammation

(2015) Ana E.V. Quaglio et al.   LIFE SCIENCES

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model

(2015) Adi Binder Gallimidi et al.   Oncotarget

Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer

(2015) Lixin Zhang et al.   NEOPLASIA

The Role of Heparanase in Pulmonary Cell Recruitment in Response to an Allergic but Not Non-Allergic Stimulus

(2015) Abigail Morris et al.   PLoS One

The potential of heparanase as a therapeutic target in cancer

(2014) Claudio Pisano et al.   BIOCHEMICAL PHARMACOLOGY

Heparanase as a Target in Cancer Therapy

(2014) Valentina Masola et al.   CURRENT CANCER DRUG TARGETS

Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy

(2014) R. Goldberg et al.   DIABETES

Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

(2014) Ivan K. H. Poon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Pancreatic Carcinoma: Role of Heparanase Enzyme

(2014) Esther Hermano et al.   JNCI-Journal of the National Cancer Institute

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

(2014) Edward Hammond et al.   Frontiers in Oncology

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models

(2013) G. Cassinelli et al.   BIOCHEMICAL PHARMACOLOGY

The Function of Heparanase in Diabetes and its Complications

(2013) Fang Wang et al.   Canadian Journal of Diabetes

Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice

(2013) J. J. Cha et al.   ENDOCRINOLOGY

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

(2013) Vishnu C. Ramani et al.   FEBS Journal

Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis

(2013) Alan C. Rapraeger   FEBS Journal

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Heparanase and Autoimmune Diabetes

(2013) Charmaine J. Simeonovic et al.   Frontiers in Immunology

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

(2012) Xiao Zhang et al.   ACTA NEUROPATHOLOGICA

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

(2012) Miry Blich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice

(2012) J. Axelsson et al.   BLOOD

Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding

(2012) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation in Diabetic Nephropathy

(2012) Andy K. H. Lim et al.   MEDIATORS OF INFLAMMATION

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice

(2012) Lili Li et al.   NEUROSCIENCE LETTERS

Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice

(2012) Sandrine Benhamron et al.   PLoS One

Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells

(2011) Fang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

The multiple roles of autophagy in cancer

(2011) M. T. Rosenfeldt et al.   CARCINOGENESIS

Exosomes and Cancer: A Newly Described Pathway of Immune Suppression

(2011) H.-G. Zhang et al.   CLINICAL CANCER RESEARCH

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Heparanase: a universal immunotherapeutic target in human cancers

(2011) Ya-Fei Zhang et al.   DRUG DISCOVERY TODAY

Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin

(2011) Bo Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation

(2011) Victoria Cohen-Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

(2011) Hamid Akbarshahi et al.   Journal of Translational Medicine

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

Targeting autophagy during cancer therapy to improve clinical outcomes

(2011) Jean M. Mulcahy Levy et al.   PHARMACOLOGY & THERAPEUTICS

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

(2010) A. Purushothaman et al.   BLOOD

Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL

(2010) Y. Yang et al.   CANCER RESEARCH

Post-transcriptional regulation of heparanase gene expression by a 3′ AU-rich element

(2010) Gil Arvatz et al.   FASEB JOURNAL

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity

(2010) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation

(2010) D. M. Beauvais et al.   JOURNAL OF CELL SCIENCE

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma

(2010) Itay Shafat et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macrophages and Diabetic Nephropathy

(2010) Greg H. Tesch   SEMINARS IN NEPHROLOGY

Enoxaparin Improves the Course of Dextran Sodium Sulfate-Induced Colitis in Syndecan-1-Deficient Mice

(2009) Martin Floer et al.   AMERICAN JOURNAL OF PATHOLOGY

Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion

(2009) Valentina Masola et al.   BMC CANCER

Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling

(2009) L. Fux et al.   CANCER RESEARCH

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heparanase expression of glioma in human and animal models

(2009) Xin Hong et al.   JOURNAL OF NEUROSURGERY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice

(2008) Aaron B. Baker et al.   CIRCULATION RESEARCH

Diabetic nephropathy: Important pathophysiologic mechanisms

(2008) G. Soldatos et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

(2008) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF CANCER

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

(2008) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function

(2008) Lars Bode et al.   JOURNAL OF CLINICAL INVESTIGATION

The anti-inflammatory effects of heparin and related compounds

(2007) Edward Young   THROMBOSIS RESEARCH