The Role of Heparanase in Pulmonary Cell Recruitment in Response to an Allergic but Not Non-Allergic Stimulus

Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

(2014) Rebecca Lever et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

(2014) Ivan K. H. Poon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults

(2014) Eric P. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

(2013) Marjolein Garsen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase)

(2011) Neha S Gandhi et al.   GLYCOBIOLOGY

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase

(2010) Ida Waern et al.   MOLECULAR IMMUNOLOGY

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Shed Syndecan-1 Restricts Neutrophil Elastase from α1-Antitrypsin in Neutrophilic Airway Inflammation

(2009) Stanley C. H. Chan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

(2009) Edward Hammond et al.   ANALYTICAL BIOCHEMISTRY

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer

(2009) M. Khasraw et al.   ANNALS OF ONCOLOGY

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Mouse Mast Cell Protease 4 Is the Major Chymase in Murine Airways and Has a Protective Role in Allergic Airway Inflammation

(2009) I. Waern et al.   JOURNAL OF IMMUNOLOGY

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

(2009) Eyal Zcharia et al.   PLoS One

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients?

(2007) Meital Cohen-Mazor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma

(2007) Simon C. Pitchford et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE