Protease-activated receptor 2 signaling in inflammation

Regulation of the Incorporation of Tissue Factor into Microparticles by Serine Phosphorylation of the Cytoplasmic Domain of Tissue Factor

(2011) Mary E. W. Collier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinase-Activated Receptor 2 Mediates Thermal Hyperalgesia and Is Upregulated in a Rat Model of Chronic Pancreatitis

(2011) Wei Zhang et al.   PANCREAS

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

(2011) L. M. Sevigny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

(2011) Simona Frateschi et al.   Nature Communications

Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium

(2010) Chang Lau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment

(2010) Toni M. Antalis et al.   BIOCHEMICAL JOURNAL

Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells

(2010) N. Magnus et al.   BLOOD

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice

(2010) R. Pawlinski et al.   BLOOD

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

(2010) F. Schaffner et al.   BLOOD

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2

(2010) Ping Wang et al.   BMC BIOCHEMISTRY

Colitis-Associated Cancer Is Dependent on the Interplay between the Hemostatic and Inflammatory Systems and Supported by Integrin αMβ2Engagement of Fibrinogen

(2010) Kris A. Steinbrecher et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Upregulation of Monocyte Tissue Factor Activity Is Significantly Associated With Low-Grade Chronic Inflammation and Insulin Resistance in Patients With Metabolic Syndrome

(2010) Akihiro Nakagomi et al.   CIRCULATION JOURNAL

Inflammation and coagulation

(2010) Marcel Levi et al.   CRITICAL CARE MEDICINE

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis

(2010) Eric Hyun et al.   INFLAMMATION RESEARCH

The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

(2010) Jennifer Disse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering of Substrate Selectivity for Tissue Factor·Factor VIIa Complex Signaling through Protease-activated Receptor 2

(2010) Katrine S. Larsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2

(2010) Maria Zoudilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

(2010) Anaïs Briot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor

(2010) Dong Hoon Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

(2010) Grant D. Barry et al.   JOURNAL OF MEDICINAL CHEMISTRY

The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice

(2010) Sachiyo Nishimura et al.   LIFE SCIENCES

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

(2010) Katiuchia Uzzun Sales et al.   NATURE GENETICS

Serine proteases and protease-activated receptor 2-dependent allodynia: A novel cancer pain pathway

(2010) D. K. Lam et al.   PAIN

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Matriptase Suppression Underlies Spint1 Mutation-Associated Ichthyosis and Postnatal Lethality

(2009) Roman Szabo et al.   AMERICAN JOURNAL OF PATHOLOGY

TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus

(2009) Shaoyong Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tissue Factor and PAR2 Signaling in the Tumor Microenvironment

(2009) Florence Schaffner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling

(2009) Fui Goon Goh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responsesin vitroandin vivo

(2009) T Kanke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity

(2009) Y. Rong et al.   CANCER RESEARCH

c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration

(2009) M. Provencal et al.   CARCINOGENESIS

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice

(2009) R. Szabo et al.   DEVELOPMENT

Inhibition of Thrombin Action Ameliorates Insulin Resistance in Type 2 Diabeticdb/dbMice

(2009) Masatomo Mihara et al.   ENDOCRINOLOGY

Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2

(2009) Burcu Hasdemir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Protease-activated Receptor-2 Differentially Regulates Desensitization and Internalization

(2009) Tiffany K. Ricks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition of Fungal Protease Activities Induces Cellular Activation and Eosinophil-Derived Neurotoxin Release in Human Eosinophils

(2009) Y. Matsuwaki et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN- -Dependent Pathway

(2009) K. Khoufache et al.   JOURNAL OF IMMUNOLOGY

Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: Involvement of pancreatic trypsin

(2009) Julien Demaude et al.   LIFE SCIENCES

Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains

(2009) R. A. Giacaman et al.   MICROBIOLOGY-SGM

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor

(2009) Mengqian Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of tissue factor/protease-activated receptor-2 signaling limits proliferation, migration and invasion of malignant glioma cells

(2009) F. Gessler et al.   NEUROSCIENCE

Alternatively spliced tissue factor induces angiogenesis through integrin ligation

(2009) Y. W. van den Berg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice

(2008) H. H. Versteeg et al.   CANCER RESEARCH

Tissue Factor Regulation by Epidermal Growth Factor Receptor and Epithelial-to-Mesenchymal Transitions: Effect on Tumor Initiation and Angiogenesis

(2008) C. C. Milsom et al.   CANCER RESEARCH

A novel secreted protease from Pseudomonas aeruginosa activates NF-κB through protease-activated receptors

(2008) Yutaka Kida et al.   CELLULAR MICROBIOLOGY

Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms

(2008) Nicolas Cenac et al.   GASTROENTEROLOGY

Protease-activated receptor-2 activation: a major actor in intestinal inflammation

(2008) E Hyun et al.   GUT

Protease-activated Receptor-2 Exerts Contrasting Model-specific Effects on Acute Experimental Pancreatitis

(2008) Johanna M. Laukkarinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mite and Cockroach Allergens Activate Protease-Activated Receptor 2 and Delay Epidermal Permeability Barrier Recovery

(2008) Se Kyoo Jeong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity

(2008) J. Apostolopoulos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists

(2008) L. R. Gardell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The contribution of PARs to inflammation and immunity to fungi

(2008) S Moretti et al.   Mucosal Immunology

Identification and immunohistochemical characterization of colospinal afferent neurons in the rat

(2008) S.K. Suckow et al.   NEUROSCIENCE

Role of Alternatively Spliced Tissue Factor in Pancreatic Cancer Growth and Angiogenesis

(2008) Maxim Signaevsky et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes

(2005) Scott R Macfarlane et al.   BRITISH JOURNAL OF PHARMACOLOGY