Allosteric antibody inhibition of human hepsin protease

Constraining Enzyme Conformational Change by an Antibody Leads to Hyperbolic Inhibition

(2011) David Oyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Allostery in trypsin-like proteases suggests new therapeutic strategies

(2011) David W. Gohara et al.   TRENDS IN BIOTECHNOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and mechanistic insight into how antibodies inhibit serine proteases

(2010) Rajkumar Ganesan et al.   BIOCHEMICAL JOURNAL

Substrate specificity and inhibitory study of human airway trypsin-like protease

(2010) M. Wysocka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

(2009) W. Li et al.   CANCER RESEARCH

Regulating transcription regulators via allostery and flexibility: Fig. 1.

(2009) Dorothy Beckett   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody

(2009) Rajkumar Ganesan et al.   STRUCTURE

How Na+ activates thrombin – a review of the functional and structural data

(2008) James A. Huntington   BIOLOGICAL CHEMISTRY

Allosteric Regulation of Proteases

(2008) Patrick Hauske et al.   CHEMBIOCHEM

Laminin-332 Is a Substrate for Hepsin, a Protease Associated with Prostate Cancer Progression

(2008) Manisha Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition

(2008) Christopher J. Farady et al.   JOURNAL OF MOLECULAR BIOLOGY

IMGT(R), the international ImMunoGeneTics information system(R)

(2008) M.-P. Lefranc et al.   NUCLEIC ACIDS RESEARCH