High-affinity Cyclic Peptide Matriptase Inhibitors

Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization

(2013) Heiko Fittler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural and Engineered Plasmin Inhibitors: Applications and Design Strategies

(2012) Joakim E. Swedberg et al.   CHEMBIOCHEM

Circular Micro-Proteins and Mechanisms of Cyclization

(2012) Brendon F. Conlan et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH

(2012) Olga Avrutina et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity

(2011) Łukajtis Rafał et al.   JOURNAL OF PEPTIDE SCIENCE

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

(2011) Joshua S Mylne et al.   Nature Chemical Biology

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1

(2011) Cai Yuan et al.   BMC STRUCTURAL BIOLOGY

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases

(2010) Anna Łęgowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumor therapies

(2010) Joanna Napp et al.   INTERNATIONAL JOURNAL OF CANCER

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

Loss of the matriptase inhibitor HAI-2 during prostate cancer progression

(2010) Christopher Bergum et al.   PROSTATE

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

(2010) Anna Legowska et al.   PROTEIN AND PEPTIDE LETTERS

Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4

(2009) Joakim E. Swedberg et al.   CHEMISTRY & BIOLOGY

Dynamics of the Streptavidin−Biotin Complex in Solution and in Its Crystal Lattice: Distinct Behavior Revealed by Molecular Simulations

(2009) David S. Cerutti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Serine peptidases: Classification, structure and function

(2008) M. J. Page et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Automated structure determination from NMR spectra

(2008) Peter Güntert   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

(2008) B. L. Barbeta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA