The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Matriptase Suppression Underlies Spint1 Mutation-Associated Ichthyosis and Postnatal Lethality

(2009) Roman Szabo et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY

Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition

(2009) Jehng-Kang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Glycosylphosphatidylinositol-Anchored Serine Protease PRSS21 (Testisin) Imparts Murine Epididymal Sperm Cell Maturation and Fertilizing Ability1

(2009) Sarah Netzel-Arnett et al.   BIOLOGY OF REPRODUCTION

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

(2009) L. Silvestri et al.   BLOOD

Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis

(2009) Joanna Selzer-Plon et al.   BMC CANCER

Suppression of the hepcidin-encoding geneHamppermits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

(2009) Jaroslav Truksa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dysfunctional Corin I555(P568) Allele Is Associated With Impaired Brain Natriuretic Peptide Processing and Adverse Outcomes in Blacks With Systolic Heart Failure

(2009) J. Eduardo Rame et al.   Circulation-Heart Failure

Autosomal recessive ichthyosis with hypotrichosis syndrome: further delineation of the phenotype

(2009) L Avrahami et al.   CLINICAL GENETICS

Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin–Darby canine kidney epithelial cells

(2009) Nobuhito Murai et al.   CYTOTECHNOLOGY

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice

(2009) R. Szabo et al.   DEVELOPMENT

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1

(2009) Carole Planès et al.   EMBO Molecular Medicine

Haematologic data, iron parameters and molecular findings in two new cases of iron-refractory iron deficiency anaemia

(2009) Isabelle Tchou et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides

(2009) François Béliveau et al.   FEBS Journal

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms

(2009) Andrew J. Ramsay et al.   HUMAN MOLECULAR GENETICS

Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity

(2009) Aya Koda et al.   HYPERTENSION RESEARCH

ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases

(2009) Thomas R. Kleyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease

(2009) K. Coote et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation

(2009) Sheau-Ling Lee et al.   MECHANISMS OF DEVELOPMENT

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor

(2009) Mengqian Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Urinary Prostasin: A Possible Biomarker for Renal Pressure Natriuresis in Black Adolescents

(2009) Haidong Zhu et al.   PEDIATRIC RESEARCH

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells

(2009) Li-Mei Chen et al.   PROSTATE

Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations

(2009) Glen Spraggon et al.   PROTEIN SCIENCE

Type II transmembrane serine proteases in cancer and viral infections

(2009) So-Young Choi et al.   TRENDS IN MOLECULAR MEDICINE

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

Prostasin: A Possible Candidate Gene for Human Hypertension

(2008) H. Zhu et al.   AMERICAN JOURNAL OF HYPERTENSION

Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1/Serine Protease Inhibitor, Kunitz Type 1 (Hai-1/Spint1) Leads to Ichthyosis-Like Condition and Abnormal Hair Development in Mice

(2008) Koki Nagaike et al.   AMERICAN JOURNAL OF PATHOLOGY

Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1

(2008) I-Chu Tseng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis

(2008) Mike M. Myerburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

α1-Antitrypsin Inhibits the Activity of the Matriptase Catalytic DomainIn Vitro

(2008) Sabina Janciauskiene et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

N-Glycosylation modulates the cell-surface expression and catalytic activity of corin

(2008) Inna P. Gladysheva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2in vitro

(2008) Robert Stallmach et al.   BIOCHEMICAL JOURNAL

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)

(2008) Andrew J. Ramsay et al.   BIOLOGICAL CHEMISTRY

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design

(2008) David C. Tully et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substrate Specificities of Porcine and Bovine Enteropeptidases toward the Peptide Val-(Asp)4-Lys-Ile-Val-Gly and Its Analogs

(2008) Yong-Tae KIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

(2008) F. Guillem et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Corin Variant Associated With Hypertension and Cardiac Hypertrophy Exhibits Impaired Zymogen Activation and Natriuretic Peptide Processing Activity

(2008) Wei Wang et al.   CIRCULATION RESEARCH

Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment

(2008) Misuzu Yamashita et al.   GENES TO CELLS

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

(2008) M. A. Melis et al.   HAEMATOLOGICA

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model

(2008) Jiangyong Miao et al.   INTERNATIONAL JOURNAL OF CANCER

Mutation G827R in Matriptase Causing Autosomal Recessive Ichthyosis with Hypotrichosis Yields an Inactive Protease

(2008) Antoine Désilets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Human Prostasin, a Target for the Regulation of Hypertension

(2008) Keith W. Rickert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laminin-332 Is a Substrate for Hepsin, a Protease Associated with Prostate Cancer Progression

(2008) Manisha Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation

(2008) Marcelo D. Carattino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity

(2008) Roman Szabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic upregulation of matriptase‐2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation

(2008) Andrew J. Sanders et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ENaC Proteolytic Regulation by Channel-activating Protease 2

(2008) Agustín García-Caballero et al.   JOURNAL OF GENERAL PHYSIOLOGY

Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension

(2008) Ai Maekawa et al.   JOURNAL OF HYPERTENSION

Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing

(2008) Thomas Alef et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma

(2008) JM Lucas et al.   JOURNAL OF PATHOLOGY

Clinical significance of low expression ofProstasinmRNA in human gastric cancer

(2008) Katsuya Sakashita et al.   JOURNAL OF SURGICAL ONCOLOGY

Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

(2008) Y. Shirogane et al.   JOURNAL OF VIROLOGY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

GeneCAT—novel webtools that combine BLAST and co-expression analyses

(2008) Marek Mutwil et al.   NUCLEIC ACIDS RESEARCH

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase–Prostasin serine protease cascade in cultured epithelial cells

(2007) Mengqian Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The MEROPS batch BLAST: A tool to detect peptidases and their non-peptidase homologues in a genome

(2007) Neil D. Rawlings et al.   BIOCHIMIE

MSPL/TMPRSS13

(2007) Hiroshi Kido   Frontiers in Bioscience-Landmark

MT-SP1 proteolysis and regulation of cell-microenvironment interactions

(2007) Molly et al.   Frontiers in Bioscience-Landmark

Zymogen activation, inhibition, and ectodomain shedding of matriptase

(2007) Chen-Yong Lin   Frontiers in Bioscience-Landmark

TMPRSS3, a type II transmembrane serine protease mutated in non-syndromic autosomal recessive deafness

(2007) Michel Guipponi   Frontiers in Bioscience-Landmark

The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

(2007) Andrew et al.   Frontiers in Bioscience-Landmark

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Corin is co-expressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms

(2007) Inna P. Gladysheva et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY