Prenatal Androgen Exposure Alters KNDy Neurons and Their Afferent Network in a Model of Polycystic Ovarian Syndrome

Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model

(2020) Lourdes A Esparza et al.   ENDOCRINOLOGY

Kisspeptin Influence on Polycystic Ovary Syndrome—a Mini Review

(2020) Bruna Silva Araújo et al.   Reproductive Sciences

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

(2020) Elisabet Stener-Victorin et al.   ENDOCRINE REVIEWS

Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome

(2020) Karolina Skorupskaite et al.   HUMAN REPRODUCTION

Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders

(2020) Ali Abbara et al.   JOURNAL OF CLINICAL INVESTIGATION

Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse

(2019) Shel-Hwa Yeo et al.   PLoS One

Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents

(2019) R. Anthony DeFazio et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells as integrators of diverse internal and external cues: evidence from viral-based monosynaptic tract-tracing in mice

(2019) Aleisha M. Moore et al.   Scientific Reports

Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome

(2019) A Romero-Ruiz et al.   HUMAN REPRODUCTION

Pathological pulses in PCOS

(2019) Christopher Coyle et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

(2019) Sanjiv Risal et al.   NATURE MEDICINE

The influence of maternal androgen excess on the male reproductive axis

(2019) Sarah Holland et al.   Scientific Reports

Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?

(2019) A. Szeliga et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Evidence from animal models on the pathogenesis of PCOS

(2018) K.A. Walters et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Prepubertal Development of GABAergic Transmission to Gonadotropin-Releasing Hormone (GnRH) Neurons and Postsynaptic Response Are Altered by Prenatal Androgenization

(2018) Tova Berg et al.   JOURNAL OF NEUROSCIENCE

Dominant neuropeptide co-transmission in kisspeptin-GABA regulation of GnRH neuron firing driving ovulation

(2018) Richard Piet et al.   JOURNAL OF NEUROSCIENCE

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

(2018) Brooke Tata et al.   NATURE MEDICINE

Polycystic Ovary Syndrome

(2018) Ricardo Azziz   OBSTETRICS AND GYNECOLOGY

Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons

(2018) Qiaoyun Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Erratum. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

(2018) Helena J Teede et al.   HUMAN REPRODUCTION

Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats

(2018) Lindsey B. Kuiper et al.   NEUROPSYCHOPHARMACOLOGY

Glutamatergic Transmission to Hypothalamic Kisspeptin Neurons Is Differentially Regulated by Estradiol through Estrogen Receptor α in Adult Female Mice

(2017) Luhong Wang et al.   JOURNAL OF NEUROSCIENCE

A Novel Ultrasensitive In Situ Hybridization Approach to Detect Short Sequences and Splice Variants with Cellular Resolution

(2017) Larissa Erben et al.   MOLECULAR NEUROBIOLOGY

Definition of the hypothalamic GnRH pulse generator in mice

(2017) Jenny Clarkson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain

(2016) Peyton W. Weems et al.   ENDOCRINOLOGY

Criteria, prevalence, and phenotypes of polycystic ovary syndrome

(2016) Daria Lizneva et al.   FERTILITY AND STERILITY

Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

(2016) Jyothis T. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

(2016) Jian Qiu et al.   eLife

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome

(2015) Daniel A. Dumesic et al.   ENDOCRINE REVIEWS

Prenatal Testosterone Treatment Leads to Changes in the Morphology of KNDy Neurons, Their Inputs, and Projections to GnRH Cells in Female Sheep

(2015) Maria Cernea et al.   ENDOCRINOLOGY

Haplosufficient Genomic Androgen Receptor Signaling Is Adequate to Protect Female Mice From Induction of Polycystic Ovary Syndrome Features by Prenatal Hyperandrogenization

(2015) A.S.L. Caldwell et al.   ENDOCRINOLOGY

Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

(2015) Su Young Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human

(2015) Katalin Skrapits et al.   Frontiers in Cellular Neuroscience

Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats

(2014) Xiaonan Yan et al.   JOURNAL OF ENDOCRINOLOGY

GABAergic Transmission to Kisspeptin Neurons Is Differentially Regulated by Time of Day and Estradiol in Female Mice

(2014) Richard A. DeFazio et al.   JOURNAL OF NEUROSCIENCE

Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome

(2014) Aleisha M. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estradiol Negative and Positive Feedback in a Prenatal Androgen-Induced Mouse Model of Polycystic Ovarian Syndrome

(2012) Aleisha M. Moore et al.   ENDOCRINOLOGY

Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome women

(2012) Manuel Maliqueo et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

(2011) Yong Xu et al.   Cell Metabolism

Evidence that the Arcuate Nucleus Is an Important Site of Progesterone Negative Feedback in the Ewe

(2011) Robert L. Goodman et al.   ENDOCRINOLOGY

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep

(2009) Guanliang Cheng et al.   ENDOCRINOLOGY

Metabolic and Reproductive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome

(2009) Teresa Sir-Petermann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

(2009) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction

(2009) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in Prodynorphin Gene Expression and Neuronal Morphology in the Hypothalamus of Postmenopausal Women

(2008) A. M. Rometo et al.   JOURNAL OF NEUROENDOCRINOLOGY