Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?

Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves

(2019) P.A. Parker et al.   THERIOGENOLOGY

Central precocious puberty: From genetics to treatment

(2018) Rebecca Schneider Aguirre et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The role of kisspeptin/neurokinin B/dynorphin neurons in pathomechanism of vasomotor symptoms in postmenopausal women: from physiology to potential therapeutic applications

(2018) Anna Szeliga et al.   GYNECOLOGICAL ENDOCRINOLOGY

Neurokinin 3 receptor antagonism rapidly improves vasomotor symptoms with sustained duration of action

(2018) Julia K. Prague et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Effect of kisspeptin antagonist on goat in vitro Leydig cell steroidogenesis

(2018) Haney Samir et al.   THERIOGENOLOGY

The neurokinin B pathway in the treatment of menopausal hot flushes

(2018) R. A. Anderson et al.   CLIMACTERIC

Neurokinin 3 receptor antagonism – a novel treatment for menopausal hot flushes

(2018) Manish Modi et al.   NEUROENDOCRINOLOGY

The direct and indirect effects of kisspeptin-54 on granulosa lutein cell function

(2017) L A Owens et al.   HUMAN REPRODUCTION

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial

(2017) Julia K Prague et al.   LANCET

Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women

(2017) Karolina Skorupskaite et al.   NEUROENDOCRINOLOGY

In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation

(2017) C. H. J. Albers-Wolthers et al.   PLoS One

Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

(2016) Jyothis T. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch

(2016) C.H.J. Albers-Wolthers et al.   THERIOGENOLOGY

Ovarian hyperstimulation syndrome in the 21st century

(2015) Lise Thomsen et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy

(2015) Ali Abbara et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gonadotropin and Estradiol Levels after Leuprolide Stimulation Tests in Brazilian Girls with Precocious Puberty

(2015) Flavia R.R. Junqueira et al.   Journal of Pediatric and Adolescent Gynecology

The Role of Kisspeptin in the Onset of Puberty and in the Ovulatory Mechanism: A Mini-review

(2015) Manuel E. Cortés et al.   Journal of Pediatric and Adolescent Gynecology

Role of a neurokinin B receptor antagonist in the regulation of ovarian function in healthy women

(2015) Karolina Skorupskaite et al.   LANCET

Kisspeptin receptor agonist (FTM080) increased plasma concentrations of luteinizing hormone in anestrous ewes

(2015) Brian K. Whitlock et al.   PeerJ

Neurokinin B Administration Induces Hot Flushes in Women

(2015) Channa N. Jayasena et al.   Scientific Reports

The kisspeptin-GnRH pathway in human reproductive health and disease

(2014) Karolina Skorupskaite et al.   HUMAN REPRODUCTION UPDATE

Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54

(2014) Channa N. Jayasena et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders

(2013) Cintia Tusset et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

(2013) Naomi E. Rance et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Kisspeptins and the reproductive axis: potential applications to manage reproduction in farm animals

(2012) A. Caraty et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications

(2012) Jacques Young et al.   NEUROENDOCRINOLOGY

Activation of Neurokinin 3 Receptors in the Median Preoptic Nucleus Decreases Core Temperature in the Rat

(2011) Penny A. Dacks et al.   ENDOCRINOLOGY

Evidence from the Agonadal Juvenile Male Rhesus Monkey (Macaca mulatta) for the View that the Action of Neurokinin B to Trigger Gonadotropin-Releasing Hormone Release Is Upstream from the Kisspeptin Receptor

(2011) Suresh Ramaswamy et al.   NEUROENDOCRINOLOGY

Kisspeptin antagonists: Unraveling the role of kisspeptin in reproductive physiology

(2010) Robert P. Millar et al.   BRAIN RESEARCH

Neurokinin B and the hypothalamic regulation of reproduction

(2010) Naomi E. Rance et al.   BRAIN RESEARCH

TAC3andTACR3Defects Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans

(2010) Jacques Young et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interaction of Kisspeptin and the Somatotropic Axis

(2010) B.K. Whitlock et al.   NEUROENDOCRINOLOGY

Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist

(2009) R. Pineda et al.   ENDOCRINOLOGY

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics

(2009) Lee A. Dawson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation

(2009) A. K. Roseweir et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

(2009) Xiao-Feng Li et al.   PLoS One

The role of kisspeptin in the control of gonadotrophin secretion

(2008) A.K. Roseweir et al.   HUMAN REPRODUCTION UPDATE

Development of Novel G-Protein-Coupled Receptor 54 Agonists with Resistance to Degradation by Matrix Metalloproteinase

(2008) Kenji Tomita et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS