Article
Genetics & Heredity
Su Liu, Ling Hong, Ruochun Lian, Shan Xiao, Yuye Li, Lianghui Diao, Yong Zeng
Summary: The aim of this study was to identify the transcriptomic characteristics of the endometrium in normoweight and overweight/obese polycystic ovary syndrome (PCOS), and it was found that there are different gene expression patterns between these two subtypes of PCOS, which may affect endometrial functions in PCOS patients.
FRONTIERS IN GENETICS
(2022)
Article
Engineering, Multidisciplinary
Jingshu Gao, Hongli Ma, Yu Wang, Xinming Yang, Yijuan Cao, Bei Zhang, Conghui Han, Xiaoke Wu
Summary: Genetic, lifestyle, and environmental factors contribute to the etiology of polycystic ovary syndrome (PCOS) in women. Higher body mass index (BMI) exacerbates reproductive and metabolic parameters, reducing fecundity of women with PCOS. The study conducted in China reveals differences in phenotypic features between Northern and Southern PCOS patients, mainly driven by discrepancies in BMI and ovulation rates.
Article
Medicine, General & Internal
Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang
Summary: This study found a genetic correlation between PCOS and obesity-related traits, including adult BMI, childhood BMI, and WHR. Cross-trait meta-analysis identified shared loci between PCOS and obesity-related traits. Mendelian randomization supported the causal role of adult BMI and childhood BMI in PCOS, but not WHR or WHRadjBMI. These findings provide insights into the shared genetic basis of obesity and PCOS and emphasize the role of weight management in PCOS prevention.
Article
Endocrinology & Metabolism
Mingze Du, Junwei Zhang, Xiaona Yu, Yichun Guan
Summary: There was no significant difference in preterm birth rate among PCOS patients with a BMI <24 kg/m(2) in different AMH level groups. However, for PCOS patients with a BMI >= 24 kg/m(2), an AMH level >6.45 ng/ml was significantly associated with a higher risk of preterm birth, indicating it as an independent risk factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Nihan Cakir Bicer, Asime Aleyna Ermis, Dilsat Bas
Summary: This study evaluated different anthropometric indices for their use in PCOS and MetS risk assessment. The results showed that VAI and WC were strong predictors of PCOS, while WC, LAP index, and BRI were strong predictors of MetS.
Article
Obstetrics & Gynecology
Jiaying Lin, Haiyan Guo, Bian Wang, Qiuju Chen, Qianqian Zhu
Summary: This study found that women with PCOS have higher odds of preterm birth after FET, but lower odds of low birth weight and SGA, especially in the subgroup with normal BMI.
FERTILITY AND STERILITY
(2021)
Review
Cardiac & Cardiovascular Systems
Chenchen Zhuang, Xufei Luo, Wenjuan Wang, Runmin Sun, Miaomiao Qi, Jing Yu
Summary: PCOS is associated with cardiovascular risk, and lipid levels and blood pressure are increased in women of reproductive age with PCOS, regardless of BMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Haiyan Guo, Bian Wang, Hongyuan Gao, Qianqian Zhu
Summary: This study aimed to investigate the impact of body mass index (BMI) on neonatal outcomes in patients with polycystic ovary syndrome (PCOS) following frozen embryo transfer (FET). The results showed that underweight mothers had a lower rate of large for gestational age (LGA) babies, while overweight mothers had a higher rate of high birth weight infants. Maternal underweight was a protective factor against LGA infants, while maternal overweight was an adverse factor.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Samata Sai Patnaik, Ramasatyasri Kotipalli, Mahesh Kumar Jerald, Kathirvel Muralidharan
Summary: The study aimed to investigate the therapeutic effect of recombinant GDF9 and Cetrorelix on DHEA-induced PCOS in rat pups. The combinational treatment normalized biochemical parameters, improved estrus irregularity, and altered sex hormones and glucose metabolism. Molecular markers expression confirmed the improvement in inflammatory and folliculogenesis genes associated with PCOS. rGDF-9 in combination with Cetrorelix could be a potential therapeutic agent for metabolic and reproductive phenotypes in PCOS.
Article
Public, Environmental & Occupational Health
Nadia Barberis, Danilo Calaresi, Marco Cannavo, Valeria Verrastro
Summary: This study found that weight issues, dysmorphic concerns, and eating disorder symptoms are common among individuals with polycystic ovary syndrome (PCOS) and are associated with poor quality of life. Dysmorphic concerns and eating disorder symptoms mediate the relationship between body mass index (BMI) and quality of life. These findings highlight the importance of harmful relationships with one's own body and food.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Hui-Juan Guan, Lin-Qing Pan, Hang Song, Huai-Yun Tang, Li-Sha Tang
Summary: This study evaluated the effects of BMI on pregnancy outcomes in PCOS patients undergoing COS and IUI, finding that obese women may require higher doses of medication and longer treatment duration to achieve pregnancy, with a potentially increased risk of gestational diabetes as BMI increases. The number of treatment cycles and type of infertility may also have predictive value for pregnancy outcomes.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Isha Rajbanshi, Vijay Kumar Sharma, Eans Tara Tuladhar, Aseem Bhattarai, Mithileshwar Raut, Raju Kumar Dubey, Poonam Koirala, Apeksha Niraula
Summary: This study aimed to assess the metabolic and hormonal profile of patients with polycystic ovarian syndrome attending a tertiary care hospital. The results showed that PCOS is most commonly prevalent in young women of the reproductive age group, which can lead to long-term reproductive, metabolic, and oncological complications. Early diagnosis and treatment of PCOS in the adolescent age group are recommended.
Article
Nutrition & Dietetics
Anna Bizon, Sylwia Placzkowska, Justyna Niepsuj, Marta Czwojdzinska, Marcin Lesniewski, Artur Nowak, Dagmara Pluta, Pawel Madej, Agnieszka Piwowar, Grzegorz Franik
Summary: This study found that women with Polycystic Ovary Syndrome (PCOS) did not show significant differences in body composition parameters compared to those without PCOS, but they had higher hormone concentrations, with sex hormone binding globulin and free testosterone correlating with all investigated body composition parameters only in the PCOS group. Additionally, logistic regression identified that the concentration of Anti-Mullerian hormones and body mass index could be useful parameters in differentiating women with PCOS from those with other disorders.ROC analysis further confirmed the concentration of Anti-Mullerian hormones as a powerful parameter for categorizing women as suffering from PCOS.
Review
Physiology
Zhu Xue, Juanli Li, Jiaxing Feng, Han Han, Jing Zhao, Jiao Zhang, Yanhua Han, Xiaoke Wu, Yuehui Zhang
Summary: The endometrium is shed periodically in response to hormone secretion, with PCOS patients at risk for disrupted endometrial function due to endocrine and metabolic abnormalities. This can lead to various complications associated with PCOS.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Psychiatry
Guopeng Li, Di Zhao, Qing Wang, Miao Zhou, Linghua Kong, Mei Fang, Ping Li
Summary: This study found that infertile women with PCOS have poor quality of life. Infertility-related stress is negatively associated with quality of life. In addition, body mass index (BMI) moderates the association between infertility-related stress and quality of life, with higher BMI exacerbating the effect of stress on quality of life.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Pathology
Juliana Pierobon Gomes da Cunha, Rodrigo Goncalves, Fernando Silva, Fernando Nalesso Aguiar, Bruna Salani Mota, Bruna Bello Chequim, Jose Maria Soares, Edmund C. Baracat, Jose Roberto Filassi
Summary: This study investigated the correlation between the Residual Cancer Burden (RCB) index and overall survival (OS) and disease-free survival (DFS) in women undergoing neoadjuvant chemotherapy for breast cancer. The results showed a significant relationship between the RCB index and the risk of relapse and death, suggesting the potential of RCB classification as a prognostic indicator.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Geriatrics & Gerontology
Giulia Paiva Oliveira Costa, Edson Santos Ferreira-Filho, Ricardo dos Santos Simoes, Jose Maria Soares-Junior, Edmund Chada Baracat, Gustavo Arantes Rosa Maciel
Summary: Women with premature ovarian insufficiency have lower bone density compared to healthy women. Hormone therapy with estrogen + progestin has a protective effect on bone mass. Higher doses of estrogen and continuous use of oral contraceptives also have a positive impact. Interrupting hormone therapy for more than a year is associated with significant bone loss.
Editorial Material
Medicine, General & Internal
Luciana C. Delamuta, Pedro A. A. Monteleone, Edson S. Ferreira-Filho, Vanessa Heinrich-Oliveira, Jose Maria Soares-Junior, Edmund C. Baracat, Gustavo Arantes Rosa Maciel
Article
Medicine, General & Internal
Daniele Carvalho Calvano Mendes, Carlos Marino Cabral Calvano Filho, Natalia Garcia, Marcos Desiderio Ricci, Jose Maria Soares Junior, Katia Candido Carvalho, Edmund Chada Baracat
Summary: The expression levels of miR-96-5p and miR-182-5p have been found to be upregulated in breast cancer, while the protein expression of FOXO3A is decreased. This phenomenon is more prominent in triple-negative breast cancer, suggesting the important role of these molecules in the biology and clinical behavior of this tumor type. These findings provide new perspectives for alternative target therapy options for breast cancer patients expressing both FOXO3A and its regulatory miRNAs.
Article
Endocrinology & Metabolism
Andrea Ramos de Castro Moreira, Ericka Trarbach, Cristina Bellotti Formiga Bueno, Anna Louise Stellfeld Monteiro, Isabella Pacetti Pajaro Grande, Mario Padula, Gustavo Arantes Rosa Maciel, Andrea Glezer
Summary: In this study, six PRL-R variants associated with prolactinomas were identified, with two variants showing higher frequency in patients compared to the genomic database. These variants were associated with male sex, higher serum PRL levels, larger tumors, and cabergoline resistance. These findings suggest the involvement of the prolactin/prolactin receptor system in prolactinoma tumorigenesis and resistance to cabergoline.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Paulo Evaristo de Andrade, Juliana Zangirolami-Raimundo, Tassiane Cristina Morais, Luiz Carlos De Abreu, Carlos Eduardo Siqueira, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Junior, Rodrigo Daminello Raimundo
Summary: The aim of this study was to analyze the autonomic modulation of heart rate in hypertensive elderly individuals during and after a session of aerobic exercise, and to compare it with elderly individuals without cardiovascular or metabolic disease. The results showed that after exercise, elderly individuals without cardiovascular and metabolic diseases had a decrease in parasympathetic modulation and global heart rate variability, but it restored within 30 minutes of post-exercise recovery. We concluded that there was no difference in autonomic modulation and global heart rate variability between elderly individuals without cardiovascular and metabolic diseases and hypertensive individuals after a bout of aerobic exercise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Maria Candida P. Baracat, Edmund C. Baracat, Ricardo S. Simoes, Manuel J. Simoes, Gustavo A. R. Maciel, Ricardo Azziz, Jose Maria Soares Jr
Summary: Our study aimed to investigate the effects of hormonal and metabolic factors on endometrial quality and progesterone action. Subjects were recruited from an outpatient reproductive endocrinology clinic. Endometrial biopsies were performed before and after progesterone treatment, and metabolic and hormonal serum levels were evaluated. The endometrium of women with PCOS in the second phase showed histomorphometric abnormalities, which were associated with androgen and insulin levels despite progesterone supplementation.
Article
Obstetrics & Gynecology
J. Zangirolami-Raimundo, R. D. Raimundo, P. R. E. Silva Noll, W. S. dos Santos, C. Leone, E. C. Baracat, I. C. E. Sorpreso, J. M. Soares Junior
Summary: This study aimed to assess whether prior knowledge of computer use determines performance of virtual reality tasks by postmenopausal women and whether menopausal symptoms, sociodemographic factors, lifestyle and cognition modify or interfere with their performance. The study found that postmenopausal computer users performed better in virtual reality games than non-users, and computer users experienced more severe vasomotor symptoms. Age, cognitive function, and headache symptoms were the best predictors affecting the postmenopausal women's performance in virtual reality tasks.
Review
Genetics & Heredity
Ana Berquo Peleja Eller, Dani Ejzenberg, Pedro Augusto Araujo Monteleone, Jose Maria Soares Jr, Edmund Chada Baracat
Summary: This review aims to assess the relationship between serum vitamin D levels and in vitro fertilization (IVF) results. The selected 18 articles showed mixed results, with some indicating a positive correlation, some lacking any association, and one exhibiting a negative correlation. Non-Hispanic White patients may be more affected by vitamin D deficiency compared to Asian patients. Vitamin D levels may play a role in the follicular fluid levels and immune system, impacting embryo implantation and pregnancy.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Cristiane Lima Roa, Jose Cipolla-Neto, Russel J. Reiter, Iara Moreno Linhares, Ana Paula Lepique, Lana Maria de Aguiar, Isadora Braga Seganfredo, Edson Santos Ferreira-Filho, Sebastiao Freitas de Medeiros, Edmund Chada Baracat, Jose Maria Soares-Jr
Summary: This study aimed to evaluate the action of melatonin, acyclovir, or the combination of melatonin with acyclovir as a suppressive treatment for recurrent genital herpes. The findings suggest that melatonin may be an effective alternative for the suppressive therapy of recurrent genital herpes.
Article
Medicine, General & Internal
Alexandra Carolina Canonica, Angelica Castilho Alonso, Guilherme Carlos Brech, Mark Peterson, Natalia Mariana Silva Luna, Alexandre Leopold Busse, Wilson Jacob-Filho, Juliana Leme Rosa, Jose Maria Soares-Junior, Edmund Chada Baracat, Julia Maria D'Aandrea Greve
Summary: This study aimed to analyze the adaptation of older adults and middle-aged adults in a driving simulator, and identify predictors of safe performance. The results showed that age, sex, and distraction play a role in the adaptation process, and certain factors such as muscle strength and postural balance are important predictors of braking time.
Article
Medicine, General & Internal
Joji Ueno, Renato De Mayrinck Salgado, Dani Ejzenberg, Filomena Marilia Henriques Carvalho, Eduardo Carvalho de Arruda Veiga, Jose Maria Soares Junior, Edmund Chada Baracat
Summary: This study aims to evaluate the influence of time and endometrial injury on pregnancy success. The results showed that the pregnancy rate was higher in the group with an interval of less than 90 days compared to the group with an interval of more than 90 days.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Biochemistry & Molecular Biology
Laura Gonzalez dos Anjos, Bruna Cristine de Almeida, Edmund Chada Baracat, Ayman Al-Hendy, Qiwei Yang, Katia Candido Carvalho
Summary: This study evaluated samples from patients with submucosal leiomyomas in metropolitan and Sao Paulo city regions, focusing on genes related to tumor development and infertility. The results showed differential gene expression between women living in metropolitan areas and Sao Paulo city, with certain genes being associated with contraceptive use, ethnicity, and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
