Review
Endocrinology & Metabolism
Aleisha M. Moore
Summary: PCOS is a common endocrinopathy and cause of infertility in women, with central neuroendocrine circuits potentially playing a key role in driving the syndrome's symptoms. Research suggests that impairments in steroid hormone feedback within the central network controlling GnRH pulse generation may be at the core of PCOS pathophysiology.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanling Wu, Belen Chanclon, Peter Micallef, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: The study demonstrates that elevated levels of adiponectin in utero can improve insulin sensitivity, reduce body weight and fat mass gain in adult offspring, and protect against PNA-induced visceral adiposity in the offspring.
Review
Biochemistry & Molecular Biology
Mauro S. B. Silva, Paolo Giacobini
Summary: Research on the physiological actions of anti-Mullerian hormone (AMH) has expanded beyond its classical role in male sexual differentiation to include regulation of ovarian function, clinical use in reproductive health, and its potential as a biomarker for polycystic ovary syndrome (PCOS). Recent studies have shown that AMH can have effects throughout the Hypothalamic-Pituitary-Gonadal (HPG) axis, providing new insights into reproductive disorders and potentially contributing to the pathophysiology of diseases such as PCOS.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Anne-Laure Barbotin, Nour El Houda Mimouni, Gregory Kuchcinski, Renaud Lopes, Romain Viard, Sowmyalakshmi Rasika, Daniele Mazur, Mauro S. B. Silva, Virginie Simon, Angele Boursier, Jean-Pierre Pruvo, Qiang Yu, Michael Candlish, Ulrich Boehm, Federica Dal Bello, Claudio Medana, Pascal Pigny, Didier Dewailly, Vincent Prevot, Sophie Catteau-Jonard, Paolo Giacobinia
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive-endocrine disorder. This study investigates the brain structure and function in PCOS patients and reveals the role of AMH in regulating fertility and neuroendocrine dysfunction.
Article
Medicine, General & Internal
Mauro S. B. Silva, Laurine Decoster, Gaspard Delpouve, Tori Lhomme, Gaetan Ternier, Vincent Prevot, Paolo Giacobini
Summary: The study manipulated GnRH neurons in adult female mice to investigate the impact of chronic overactivation on PCOS-like hormonal and reproductive impairments. The results showed that hyperactivity of hypothalamic GnRH neurons is a major driver of reproductive and hormonal impairments in PCOS, and antagonizing the aberrant GnRH signaling could be an efficient therapeutic venue for the treatment of PCOS.
Article
Cell Biology
Siva Prasad Panda, Adarsh Kesharwani, Gaurav Deep Singh, D. S. N. B. K. Prasanth, Bhaskara Raju Vatchavai, P. V. Kamala Kumari, Sunil Kumar Panda, Sarada Prasanna Mallick
Summary: The interaction of KISS1/KISS1R in the hypothalamus plays a regulatory role in the reproductive stage, and its decrease with ageing may lead to dysfunction. KNDy neurons are crucial for the release of GnRH and neuroendocrine function.
AGEING RESEARCH REVIEWS
(2023)
Article
Obstetrics & Gynecology
Shabnam Salemi, Azar Yahyaei, Samira Vesali, Firouzeh Ghaffari
Summary: This study investigated the effects of GnRH agonist pre-treatment in patients with PCOS undergoing vitrified-warmed embryo transfer. The results showed that there were no significant differences in pregnancy outcomes between patients receiving GnRH agonist and those who did not, indicating that both methods provide similar results in endometrial preparation for frozen-thawed embryo transfer.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Endocrinology & Metabolism
Akanksha Garg, Bijal Patel, Ali Abbara, Waljit S. Dhillo
Summary: PCOS is the most common endocrine disorder in women of reproductive age, and its increased GnRH pulsatility is caused by various factors. Targeting the activity of KNDy neurons using pharmaceutical agents is being researched as a potential method to alleviate symptoms of PCOS. Neurokinin 3 receptor antagonists show promise in reducing GnRH pulsatility and relieving PCOS symptoms.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinhuai Liu, Robert Porteous, Allan E. Herbison
Summary: GABAergic inputs to the distal dendron of GnRH neurons are regulated in a sex- and estrous cycle-dependent manner, with robust GABA(B) receptor-mediated inhibition being the primary mode of signaling. This provides a new, kisspeptin-independent, pathway for the regulation of pulsatile and surge modes of GnRH secretion in rodents.
Article
Medicine, General & Internal
Bin Wang, Zhiling Li
Summary: The dual-trigger regime has shown advantages over the HCG-only trigger regime in reproductive outcomes for PCOS couples undergoing COS and IUI. The dual-trigger group had higher live birth rate, clinical pregnancy rate, and beta-HCG positive rate compared to the HCG-only group, with lower early miscarriage rate and multiple pregnancy rate.
Article
Biochemical Research Methods
Enrica Mecarelli, Riccardo Aigotti, Alberto Asteggiano, Paolo Giacobini, Manon Chasles, Yves Tillet, Federica Dal Bello, Claudio Medana
Summary: This study presents a validated nano-high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS) method for quantifying GnRH in ewe plasma samples. The method includes protein precipitation and solid-phase extraction (SPE) pre-treatment steps to purify and enrich GnRH and internal standard. The validation process confirmed the feasibility of using a surrogate matrix and achieved acceptable values for parameters such as selectivity, accuracy, precision, recovery, and matrix effect. The developed nano-HPLC-HRMS technique successfully measured GnRH in ewe plasma, making it suitable for quantifying GnRH in various matrices and species.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Bradley B. B. Jamieson, Aleisha M. M. Moore, Dayanara B. B. Lohr, Simone X. X. Thomas, Lique M. M. Coolen, Michael N. N. Lehman, Rebecca E. E. Campbell, Richard Piet
Summary: Polycystic ovary syndrome (PCOS) is characterized by elevated androgen and luteinizing hormone (LH) secretion and ovulation dysfunction. A study found that elevated androgens in PCOS impair the feedback regulation of LH secretion, as well as the preovulatory LH surge. Using a mouse model of PCOS, the study showed that elevated androgens change neural circuits involved in regulating the preovulatory surge, which may contribute to ovulation dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Aleisha M. Moore, Dayanara B. Lohr, Lique M. Coolen, Michael N. Lehman
Summary: Alterations in gene expression within KNDy neurons and reduced synaptic inputs from steroid hormone-responsive hypothalamic regions may contribute to defects in negative feedback in PCOS. The specific roles of these changes in contributing to the neuroendocrine phenotype seen in PCOS, as well as the involvement of specific sets of upstream KNDy afferents in the process, remain to be determined.
Article
Endocrinology & Metabolism
Aleisha M. Moore, Dayanara B. Lohr, Lique M. Coolen, Michael N. Lehman
Summary: PCOS, the most common endocrinopathy affecting women worldwide, is characterized by impaired negative feedback. This study explored the role of KNDy neurons in PCOS pathogenesis, revealing potential defects in negative feedback due to changes in gene expression within KNDy neurons and synaptic inputs from steroid hormone-responsive hypothalamic regions. Further research is needed to determine the specific contributions of these alterations to the neuroendocrine phenotype seen in PCOS.
Article
Endocrinology & Metabolism
Ali Abbara, Maria Phylactou, Pei Chia Eng, Sophie A. Clarke, Toan D. Pham, Tuong M. Ho, Kah Yan Ng, Edouard G. Mills, Kate Purugganan, Tia Hunjan, Rehan Salim, Alexander N. Comninos, Lan N. Vuong, Waljit S. Dhillo
Summary: This study compared the endocrine response to triptorelin in women with different reproductive conditions. It found that women with PCOS had a lesser increase in FSH levels compared to healthy women and HA women after triptorelin administration. Additionally, women with polycystic ovaries had lower FSH levels after triptorelin, both with and without ovarian stimulation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Behavioral Sciences
Daniella C. Buonfiglio, Angela M. Ramos-Lobo, Marina A. Silveira, Isadora C. Furigo, Lothar Hennighausen, Renata Frazao, Jose Donato
HORMONES AND BEHAVIOR
(2015)
Article
Endocrinology & Metabolism
Marina A. Silveira, Laura L. Burger, Anthony DeFazio, Elizabeth R. Wagenmaker, Suzanne M. Moenter
Article
Endocrinology & Metabolism
Joao A. B. Pedroso, Marina A. Silveira, Leandro B. Lima, Isadora C. Furigo, Thais T. Zampieri, Angela M. Ramos-Lobo, Daniella C. Buonfiglio, Pryscila D. S. Teixeira, Renata Frazao, Jose Donato
Article
Cell Biology
Tabata M. Bohlen, Marina A. Silveira, Thais T. Zampieri, Renata Frazao, Jose Donato
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Cell Biology
Marina Augusto Silveira, Isadora C. Furigo, Thais T. Zampieri, Tabata M. Bohlen, Daniella G. de Paula, Celso Rodrigues Franci, Jose Donato, Renata Frazao
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Article
Neurosciences
Leandro Bueno Lima, Fernanda Tais Haubenthal, Marina Augusto Silveira, Tabata Mariz Bohlen, Martin Metzger, Jose Donato Jr, Renato Frazao
NEUROSCIENCE LETTERS
(2018)
Article
Endocrinology & Metabolism
Tabata Mariz Bohlen, Marina Augusto Silveira, Daniella do Carmo Buonfiglio, Hildebrando Candido Ferreira-Neto, Jose Cipolla-Neto, Jose Donato, Renata Frazao
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Endocrinology & Metabolism
Suzanne M. Moenter, Marina A. Silveira, Luhong Wang, Caroline Adams
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Biology
David Goyer, Marina A. Silveira, Alexander P. George, Nichole L. Beebe, Ryan M. Edelbrock, Peter T. Malinski, Brett R. Schofield, Michael T. Roberts
Article
Neurosciences
Marina A. Silveira, Thais T. Zampieri, Isadora C. Furigo, Fernando Abdulkader, Jose Donato, Renata Frazao
Article
Neurosciences
Marina A. Silveira, Justin D. Anair, Nichole L. Beebe, Pooyan Mirjalili, Brett R. Schofield, Michael T. Roberts
JOURNAL OF NEUROSCIENCE
(2020)