Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

(2020) Patrick Lüningschrör et al.   Cell Reports

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

(2020) M. Eugenia Dieterle et al.   Cell Host & Microbe

In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

(2020) Xiao-Jing Zhang et al.   Cell Metabolism

Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

(2020) Eskild Petersen et al.   LANCET INFECTIOUS DISEASES

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

(2020) Yuan-Lin Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients

(2020) Lori B. Daniels et al.   AMERICAN JOURNAL OF CARDIOLOGY

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Can Activation of NRF2 Be a Strategy against COVID-19?

(2020) Antonio Cuadrado et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

(2019) Mike Flint et al.   Nature Communications

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

(2019) Philip V'kovski et al.   eLife

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

(2019) Ruben J. G. Hulswit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in Bunyavirus entry

(2019) Frank W. Charlton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio

(2018) Sarah Edie et al.   G3-Genes Genomes Genetics

The exocyst complex

(2018) Kunrong Mei et al.   CURRENT BIOLOGY

TMEM41B is a novel regulator of autophagy and lipid mobilization

(2018) Francesca Moretti et al.   EMBO REPORTS

Network propagation: a universal amplifier of genetic associations

(2017) Lenore Cowen et al.   NATURE REVIEWS GENETICS

A CRISPR toolbox to study virus–host interactions

(2017) Andreas S. Puschnik et al.   NATURE REVIEWS MICROBIOLOGY

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice

(2017) Zoe A. Klein et al.   NEURON

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin

(2016) Radu Rapiteanu et al.   TRAFFIC

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

(2016) Maxime WC Rousseaux et al.   eLife

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Combating emerging viral threats

(2015) E. Bekerman et al.   SCIENCE

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

(2015) Lara M. Kleinfelter et al.   mBio

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection

(2014) Josiah Petersen et al.   PLoS Pathogens

Glycan Engagement by Viruses: Receptor Switches and Specificity

(2014) Luisa J. Ströh et al.   Annual Review of Virology

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

(2011) K. T. Beier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLay: community structure analysis of biological networks

(2010) G. Su et al.   BIOINFORMATICS

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Pathway Commons, a web resource for biological pathway data

(2010) E. G. Cerami et al.   NUCLEIC ACIDS RESEARCH

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

(2009) Shinji Kamisuki et al.   CHEMISTRY & BIOLOGY

Identification of the Neuroblastoma-amplified Gene Product as a Component of the Syntaxin 18 Complex Implicated in Golgi-to-Endoplasmic Reticulum Retrograde Transport

(2009) Takehiro Aoki et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals

(2008) J. L. Hawkins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

(2008) Yusuke Maeda et al.   NATURE CELL BIOLOGY