Emerging single-cell technologies for functional proteomics in oncology

Multifunctional Hydrogel Microparticles by Polymer-Assisted Photolithography

(2016) Bin Li et al.   ACS Applied Materials & Interfaces

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma

(2016) Wei Wei et al.   CANCER CELL

Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells

(2015) Yu Zhang et al.   ANALYTICAL CHEMISTRY

Unraveling cell populations in tumors by single-cell mass cytometry

(2015) Serena Di Palma et al.   CURRENT OPINION IN BIOTECHNOLOGY

Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells

(2015) Min Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-cell analysis tools for drug discovery and development

(2015) James R. Heath et al.   NATURE REVIEWS DRUG DISCOVERY

Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

(2015) Yao Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Western Blotting after Whole-Cell Imaging to Assess Cancer Chemotherapeutic Response

(2014) Chi-Chih Kang et al.   ANALYTICAL CHEMISTRY

Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications

(2014) Jing Yu et al.   Annual Review of Analytical Chemistry

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

(2014) Jimmy L. Zhao et al.   Cell Stem Cell

A microchip platform for interrogating tumor–macrophage paracrine signaling at the single-cell level

(2014) Meltem Elitas et al.   LAB ON A CHIP

SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations

(2014) Francesca Mateo et al.   Molecular Cancer

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

(2014) Allison S. Cleary et al.   NATURE

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Single-cell western blotting

(2014) Alex J Hughes et al.   NATURE METHODS

Single-cell in situ RNA profiling by sequential hybridization

(2014) Eric Lubeck et al.   NATURE METHODS

Glioblastoma cellular architectures are predicted through the characterization of two-cell interactions

(2014) N. Kravchenko-Balasha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-reactivity in antibody microarrays and multiplexed sandwich assays: shedding light on the dark side of multiplexing

(2013) David Juncker et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fast Metabolic Response to Drug Intervention Through Analysis on a Miniaturized, Highly Integrated Molecular Imaging System

(2013) J. Wang et al.   JOURNAL OF NUCLEAR MEDICINE

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Single-Cell Analysis Reveals Isotype-Specific Autoreactive B Cell Repertoires in Sjögren’s Syndrome

(2013) Cuong Q. Nguyen et al.   PLoS One

Hypoxia induces a phase transition within a kinase signaling network in cancer cells

(2013) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy

(2013) Chao Ma et al.   Cancer Discovery

Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research

(2013) Wei Wei et al.   Genome Medicine

Microarray-to-Microarray Transfer of Reagents by Snapping of Two Chips for Cross-Reactivity-Free Multiplex Immunoassays

(2012) Huiyan Li et al.   ANALYTICAL CHEMISTRY

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells

(2012) Jun Wang et al.   NANO LETTERS

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving

(2012) N. Varadarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling

(2011) Young Shik Shin et al.   BIOPHYSICAL JOURNAL

An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition

(2011) Lauren MF Merlo et al.   BMC CANCER

Heterogeneity Maintenance in Glioblastoma: A Social Network

(2011) R. Bonavia et al.   CANCER RESEARCH

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

(2011) Navin Varadarajan et al.   JOURNAL OF CLINICAL INVESTIGATION

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

(2011) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Chemistries for Patterning Robust DNA MicroBarcodes Enable Multiplex Assays of Cytoplasm Proteins from Single Cancer Cells

(2010) Young Shik Shin et al.   CHEMPHYSCHEM

Massively parallel detection of gene expression in single cells using subnanolitre wells

(2010) Yuan Gong et al.   LAB ON A CHIP

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Quantum Dots for Live Cell and In Vivo Imaging

(2009) Maureen Walling et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model

(2009) Gagliano   ONCOLOGY REPORTS

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

(2008) Rong Fan et al.   NATURE BIOTECHNOLOGY