Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Microfluidic Chips for Immunoassays

(2013) Kwi Nam Han et al.   Annual Review of Analytical Chemistry

Single-Cell Analysis Reveals Isotype-Specific Autoreactive B Cell Repertoires in Sjögren’s Syndrome

(2013) Cuong Q. Nguyen et al.   PLoS One

Hypoxia induces a phase transition within a kinase signaling network in cancer cells

(2013) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue

(2013) M. J. Gerdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell DNA-Methylation Analysis Reveals Epigenetic Chimerism in Preimplantation Embryos

(2013) C. Lorthongpanich et al.   SCIENCE

Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy

(2013) Chao Ma et al.   Cancer Discovery

Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research

(2013) Wei Wei et al.   Genome Medicine

Digital Microfluidics

(2012) Kihwan Choi et al.   Annual Review of Analytical Chemistry

Turning single cells into microarrays by super-resolution barcoding

(2012) L. Cai   Briefings in Functional Genomics

Mass spectrometry-based proteomics: existing capabilities and future directions

(2012) Thomas E. Angel et al.   CHEMICAL SOCIETY REVIEWS

Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

(2012) J. S. Logue et al.   GENES & DEVELOPMENT

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells

(2012) Yvonne J. Yamanaka et al.   Integrative Biology

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells

(2012) Alexis J. Torres et al.   LAB ON A CHIP

Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells

(2012) Jun Wang et al.   NANO LETTERS

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Predicting rates of cell state change caused by stochastic fluctuations using a data-driven landscape model

(2012) D. R. Sisan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective and single cell behavior in epithelial contact inhibition

(2012) A. Puliafito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving

(2012) N. Varadarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Protein Determination Using Droplet-Based Immunoassays

(2011) Chiara Martino et al.   ANALYTICAL CHEMISTRY

High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications

(2011) Udi Vermesh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell chip array for microfluidic proteomics enabling rapid in situ assessment of intracellular protein phosphorylation

(2011) Shannon L. Faley et al.   Biomicrofluidics

Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling

(2011) Young Shik Shin et al.   BIOPHYSICAL JOURNAL

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments

(2011) K. D. Gibbs et al.   BLOOD

Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

(2011) Tina L. Yuan et al.   CURRENT BIOLOGY

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

(2011) Navin Varadarajan et al.   JOURNAL OF CLINICAL INVESTIGATION

A microchamber array for single cell isolation and analysis of intracellular biomolecules

(2011) Klaus Eyer et al.   LAB ON A CHIP

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

(2011) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A robotics platform for automated batch fabrication of high density, microfluidics-based DNA microarrays, with applications to single cell, multiplex assays of secreted proteins

(2011) Habib Ahmad et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology

(2010) Ashleigh B. Theberge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic Platforms for Single-Cell Analysis

(2010) Richard N. Zare et al.   Annual Review of Biomedical Engineering

Response definition criteria for ELISPOT assays revisited

(2010) Z. Moodie et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens

(2010) J. Sun et al.   CANCER RESEARCH

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Chemistries for Patterning Robust DNA MicroBarcodes Enable Multiplex Assays of Cytoplasm Proteins from Single Cancer Cells

(2010) Young Shik Shin et al.   CHEMPHYSCHEM

Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving

(2010) Qing Han et al.   LAB ON A CHIP

Massively parallel detection of gene expression in single cells using subnanolitre wells

(2010) Yuan Gong et al.   LAB ON A CHIP

Measurement of single-cell dynamics

(2010) David G. Spiller et al.   NATURE

Population robustness arising from cellular heterogeneity

(2010) P. Paszek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

(2009) Shannon L. Faley et al.   LAB ON A CHIP

Nano-imaging with STORM

(2009) Xiaowei Zhuang   Nature Photonics

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies

(2008) Elizabeth M. Bradshaw et al.   CLINICAL IMMUNOLOGY

Optimization of the surfaces used to capture antibodies from single hybridomas reduces the time required for microengraving

(2008) Jehnna L. Ronan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

(2008) Rong Fan et al.   NATURE BIOTECHNOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Nanotechnology and Cancer

(2007) James R. Heath et al.   Annual Review of Medicine