Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 6, Pages 4158-4164Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11883
Keywords
photoresist; photolithography; multilayer; hydrogel; microarray
Funding
- Presidential Initiatives Fund for Research and Scholarship
- University at Albany, State University of New York
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Although standard lithography has been the most common technique in micropatteming, ironically it has not been adopted to produce multifunctional hydrogel microparticles, which are highly useful for bioassays. We address this issue by developing a negative photoresist-like polymer system, which is basically comprised of polyethylene glycol (PEG) triacrylate as cross-linking units and long-chain polyvinylpyrrolidone (PVP) as the supporting scaffold. We leverage standard lithography to manufacture multilayer microparticles that are intrinsically hydrophilic, low-autofluorescent, and chemically reactive. The versatility of the microparticles is demonstrated to be color-encoded, pore controllable, bioactive, and potentially used as a DNA bioassay.
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