AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke

Microglial/Macrophage polarization and function in brain injury and repair after stroke

(2021) Junxuan Lyu et al.   CNS Neuroscience & Therapeutics

Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia

(2021) Hansen Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2020) Neda Haghayegh Jahromi et al.   Frontiers in Immunology

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice

(2020) Saifudeen Ismael et al.   MOLECULAR NEUROBIOLOGY

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

(2020) Uddalak Bharadwaj et al.   PHARMACOLOGICAL REVIEWS

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

(2020) Judith Hauptmann et al.   ACTA NEUROPATHOLOGICA

Telmisartan Inhibits TNF-Alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells

(2020) Changhwan Jang et al.   Biomolecules & Therapeutics

Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

(2020) Qiao‐sheng Wang et al.   CNS Neuroscience & Therapeutics

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair

(2020) Hila Israelov et al.   Journal of Neuroinflammation

Therapeutic role of inflammasome inhibitors in neurodegenerative disorders

(2020) Behnaz Lahooti et al.   BRAIN BEHAVIOR AND IMMUNITY

Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway

(2019) Yanni Lv et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke

(2019) Pin-yi Liu et al.   Frontiers in Cellular Neuroscience

Rosiglitazone ameliorates tissue plasminogen activator‐induced brain hemorrhage after stroke

(2019) Yan Li et al.   CNS Neuroscience & Therapeutics

The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome

(2019) Mei‐Juan Zhang et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Signaling Is Involved in Impaired Blood–Brain Barrier Function in Ischemia–Reperfusion Injury

(2019) Shinsuke Nakagawa et al.   MOLECULAR NEUROBIOLOGY

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

The IL-6/STAT3 pathway regulates adhesion molecules and cytoskeleton of endothelial cells in thromboangiitis obliterans

(2018) Zheng Wei et al.   CELLULAR SIGNALLING

SNHG12 Promotes Angiogenesis Following Ischemic Stroke via Regulating miR-150/VEGF Pathway

(2018) Mian Zhao et al.   NEUROSCIENCE

β1-integrin–matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability

(2017) Yoshikane Izawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage

(2017) Biying Ji et al.   Translational Stroke Research

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

(2016) Rojo A Ratsimandresy et al.   Cellular & Molecular Immunology

Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy

(2016) Jang-Hyuk Yun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit

(2015) Islam N. Mohamed et al.   ANTIOXIDANTS & REDOX SIGNALING

Relation between stroke severity, patient characteristics and CT-perfusion derived blood-brain barrier permeability measurements in acute ischemic stroke

(2015) Alexander D. Horsch et al.   Clinical Neuroradiology

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Acute Ischemic Stroke

(2014) Nathan W. Manning et al.   STROKE

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effects of preconditioning on tight junction and cell adhesion of cerebral endothelial cells

(2009) Ping An et al.   BRAIN RESEARCH