Sphingosine 1-Phosphate Signaling Is Involved in Impaired Blood–Brain Barrier Function in Ischemia–Reperfusion Injury

Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke

(2019) Angélica Salas-Perdomo et al.   Scientific Reports

Functional morphology of the blood–brain barrier in health and disease

(2018) Stefan Liebner et al.   ACTA NEUROPATHOLOGICA

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MicroRNA-149-5p regulates blood–brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes

(2018) Yan Wan et al.   FASEB JOURNAL

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

(2018) Christina Christoffersen et al.   Cell Reports

Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet

(2018) John CL Mamo et al.   Diabetes & Vascular Disease Research

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice

(2016) Yeon Suk Jung et al.   ACTA PHARMACOLOGICA SINICA

The Translational Significance of the Neurovascular Unit

(2016) Heather L. McConnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets

(2016) Na Sun et al.   Translational Stroke Research

Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke

(2016) Wentao Li et al.   Frontiers in Neurology

Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors

(2016) Rachael Wiltshire et al.   Scientific Reports

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia

(2015) Shuli Zheng et al.   EXPERIMENTAL NEUROLOGY

Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood-Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner

(2015) P. Reeson et al.   JOURNAL OF NEUROSCIENCE

Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood–Brain Barrier and White Matter Damage After Stroke

(2015) Xu Cui et al.   STROKE

Sphingosine 1-phosphate signaling at the blood–brain barrier

(2015) Briana Prager et al.   TRENDS IN MOLECULAR MEDICINE

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia

(2014) Fernando D. Testai et al.   JOURNAL OF NEUROCHEMISTRY

Cilostazol attenuates ischemia–reperfusion-induced blood–brain barrier dysfunction enhanced by advanced glycation endproducts via transforming growth factor-β1 signaling

(2014) Tomonori Takeshita et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular and physiological functions of sphingosine 1-phosphate transporters

(2013) Tsuyoshi Nishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipopolysaccharide Disrupts the Milk-Blood Barrier by Modulating Claudins in Mammary Alveolar Tight Junctions

(2013) Ken Kobayashi et al.   PLoS One

Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury

(2013) Emmanuel E. Egom et al.   Frontiers in Physiology

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding

(2012) Ryusuke Takechi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Probucol and atorvastatin in combination protect rat brains in MCAO model: Upregulating Peroxiredoxin2, Foxo3a and Nrf2 expression

(2012) Yuanyuan Du et al.   NEUROSCIENCE LETTERS

LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells

(2012) Jing Du et al.   PATHOLOGY RESEARCH AND PRACTICE

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining

(2012) Estelle Rousselet et al.   Jove-Journal of Visualized Experiments

Pharmacologic Suppression of Hepatic ATP-Binding Cassette Transporter 1 Activity in Mice Reduces High-Density Lipoprotein Cholesterol Levels but Promotes Reverse Cholesterol Transport

(2011) Shigenori Yamamoto et al.   CIRCULATION

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia–reperfusion

(2011) Yanjun Shi et al.   JOURNAL OF HEPATOLOGY

Combinatorial Effect of Probucol and Cilostazol in Focal Ischemic Mice with Hypercholesterolemia

(2011) J. H. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Where are we with probucol: A new life for an old drug?

(2009) Shizuya Yamashita et al.   ATHEROSCLEROSIS

Vessel microport technique for applications in cerebrovascular research

(2009) Lei Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

In Situ Mouse Carotid Perfusion Model: Glucose and Cholesterol Transport in the Eye and Brain

(2008) Julie Cattelotte et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL