The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome

HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

(2019) Qiuchen Zhao et al.   Journal of Neuroinflammation

HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection

(2018) Jian Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Microbiome and Risk for Atherosclerosis

(2018) Anthony L. Komaroff   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPARγ activity in vitro

(2018) Qiuchen Zhao et al.   JOURNAL OF NEUROCHEMISTRY

HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals

(2017) Josef Večeřa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

(2017) Mingxu Xia et al.   NEURAL PLASTICITY

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

(2016) Chiara Angiolilli et al.   ANNALS OF THE RHEUMATIC DISEASES

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

(2016) Niek G.J. Leus et al.   BIOCHEMICAL PHARMACOLOGY

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Post-translational regulation of inflammasomes

(2016) Jie Yang et al.   Cellular & Molecular Immunology

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type

(2016) Daojing Li et al.   FASEB JOURNAL

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

(2016) Xiaoyu Yang et al.   Frontiers in Molecular Neuroscience

AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice

(2016) Pei-Jung Wu et al.   Scientific Reports

DNA sensors are expressed in astrocytes and microgliain vitroand are upregulated during gliosis in neurodegenerative disease

(2015) Donal J. Cox et al.   GLIA

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

(2014) M. A. Hoeksema et al.   EMBO Molecular Medicine

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

(2014) Hyo-Kyoung Choi et al.   HUMAN MOLECULAR GENETICS

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

(2014) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

Regulation of STAT signaling by acetylation

(2013) Shougang Zhuang   CELLULAR SIGNALLING

HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation

(2013) G. A. Rogge et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

(2013) M. Malvaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection

(2012) Yan-Ting Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

(2012) Haiqun Jia et al.   NEUROBIOLOGY OF DISEASE

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE