Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site

Understanding STAT3 signaling in cardiac ischemia

(2016) K. E. O’Sullivan et al.   BASIC RESEARCH IN CARDIOLOGY

Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury

(2016) Yang Yang et al.   BASIC RESEARCH IN CARDIOLOGY

Melatonin: the dawning of a treatment for fibrosis?

(2016) Wei Hu et al.   JOURNAL OF PINEAL RESEARCH

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

(2016) Zhenxing Liang et al.   PROGRESS IN NEUROBIOLOGY

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling

(2015) Daichi Enomoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury

(2015) Karol Szczepanek et al.   BASIC RESEARCH IN CARDIOLOGY

Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice

(2015) Carlota Recio et al.   BASIC RESEARCH IN CARDIOLOGY

Interleukin-27, a novel cytokine induced by ischemia–reperfusion injury in rat hearts, mediates cardioprotective effects via the gp130/STAT3 pathway

(2015) Ming-Chieh Ma et al.   BASIC RESEARCH IN CARDIOLOGY

IL-9 aggravates the development of atherosclerosis in ApoE-/- mice

(2015) W. Zhang et al.   CARDIOVASCULAR RESEARCH

Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

(2015) G. Heusch   CIRCULATION RESEARCH

Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement PathwaysNovelty and Significance

(2015) Andreas Skyschally et al.   CIRCULATION RESEARCH

Remote Ischemic Conditioning

(2015) Gerd Heusch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

(2015) Borja Ibáñez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

(2015) Jong Hyun Lee et al.   Oncotarget

The RIPOST-MI study, assessing remote ischemic perconditioning alone or in combination with local ischemic postconditioning in ST-segment elevation myocardial infarction

(2014) Fabrice Prunier et al.   BASIC RESEARCH IN CARDIOLOGY

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction

(2014) Julia Müller et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3 : cardiovascular topic

(2014) Roisin F. Kelly-Laubscher et al.   Cardiovascular Journal of Africa

STAT3, a key regulator of cell-to-cell communication in the heart

(2014) Arash Haghikia et al.   CARDIOVASCULAR RESEARCH

Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis

(2014) Ding Ai et al.   CIRCULATION RESEARCH

Loss of STAT3 in mouse embryonic fibroblasts reveals its Janus-like actions on mitochondrial function and cell viability

(2014) Fouad A. Zouein et al.   CYTOKINE

Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis

(2014) S. Saravanan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration

(2014) D. Zhang et al.   JOURNAL OF CELL SCIENCE

Cardiovascular remodelling in coronary artery disease and heart failure

(2014) Gerd Heusch et al.   LANCET

Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart

(2014) Karol A. Kamiński et al.   Pharmacological Reports

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits

(2013) Yoshihisa Yamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

S-Propargyl-Cysteine, a Novel Water-Soluble Modulator of Endogenous Hydrogen Sulfide, Promotes Angiogenesis Through Activation of Signal Transducer and Activator of Transcription 3

(2013) Juntao Kan et al.   ANTIOXIDANTS & REDOX SIGNALING

HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity

(2013) Miguel A. Frias et al.   ATHEROSCLEROSIS

The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

(2013) Kerstin Boengler et al.   CURRENT PHARMACEUTICAL DESIGN

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

(2013) Annalisa Camporeale et al.   EMBO Molecular Medicine

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury

(2013) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced preservation of the rat heart after prolonged hypothermic ischemia with erythropoietin-supplemented Celsior solution

(2013) Alasdair J. Watson et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

(2013) Maren Leifheit-Nestler et al.   Journal of Translational Medicine

Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2

(2013) Ewa Przybyt et al.   Journal of Translational Medicine

New Role of JAK2/STAT3 Signaling in Endothelial Cell Oxidative Stress Injury and Protective Effect of Melatonin

(2013) Weixun Duan et al.   PLoS One

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

(2013) Gerardo G. Mackenzie et al.   PLoS One

The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death

(2013) G Wang et al.   Cell Death & Disease

Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart

(2012) Masanori Obana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway

(2012) Weixun Duan et al.   BASIC RESEARCH IN CARDIOLOGY

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway

(2012) Antonio Cittadini et al.   CARDIOVASCULAR RESEARCH

Regulation of JAK/STAT signalling by SOCS in the myocardium

(2012) J. Shi et al.   CARDIOVASCULAR RESEARCH

Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB

(2012) Suresh Kumar Verma et al.   CIRCULATION

Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells

(2012) Myriam Elschami et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Melatonin in cardiovascular disease

(2012) Alberto Dominguez-Rodriguez   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

Thrombopoietin improved ventricular function and regulated remodeling genes in a rat model of myocardial infarction

(2012) Kathy Yuen Yee Chan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol induces nuclear factor-κB activity in human cardiac cells

(2012) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury

(2012) Hong Ma et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction

(2012) Toyoharu Oba et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardioprotection: chances and challenges of its translation to the clinic

(2012) Gerd Heusch   LANCET

Erythropoietin alleviates post-ischemic injury of rat hearts by attenuating nitrosative stress

(2012) Ming-Jen Lu et al.   LIFE SCIENCES

STAT3 Regulates Monocyte TNF-Alpha Production in Systemic Inflammation Caused by Cardiac Surgery with Cardiopulmonary Bypass

(2012) Petrus R. de Jong et al.   PLoS One

Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling

(2012) Coert J. Zuurbier et al.   PLoS One

Leptin attenuates ischemia-reperfusion injury in the rat liver

(2012) Marco Carbone et al.   TRANSPLANT INTERNATIONAL

Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

(2012) Karol Szczepanek et al.   TRENDS IN CELL BIOLOGY

Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy

(2011) Hyun Ah Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury

(2011) Chunyan Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning

(2011) Sophie Tamareille et al.   BASIC RESEARCH IN CARDIOLOGY

H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload

(2011) Hongyu Qiu et al.   CIRCULATION

Mitochondrial STAT3 Activation and Cardioprotection by Ischemic Postconditioning in Pigs With Regional Myocardial Ischemia/Reperfusion

(2011) Gerd Heusch et al.   CIRCULATION RESEARCH

Interleukin-10 Deficiency Impairs Bone Marrow–Derived Endothelial Progenitor Cell Survival and Function in Ischemic Myocardium

(2011) Prasanna Krishnamurthy et al.   CIRCULATION RESEARCH

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

(2011) Karol Szczepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism

(2011) Wei Ge et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Ischemia/reperfusion injury: The benefit of having STAT3 in the heart

(2011) Kerstin Boengler   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

(2011) Roberto Bolli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

(2011) Réka Skoumal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium

(2011) Adam B. Stein et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection

(2011) Kim T. Lamont et al.   JOURNAL OF PINEAL RESEARCH

Intracoronary Mesenchymal Stem Cells Promote Postischemic Myocardial Functional Recovery, Decrease Inflammation, and Reduce Apoptosis via a Signal Transducer and Activator of Transcription 3 Mechanism

(2011) Jeffrey A. Poynter et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Curcumin Inhibits Neuronal and Vascular Degeneration in Retina after Ischemia and Reperfusion Injury

(2011) Leilei Wang et al.   PLoS One

Neuroprotection by leptin in a rat model of permanent cerebral ischemia: effects on STAT3 phosphorylation in discrete cells of the brain

(2011) D Amantea et al.   Cell Death & Disease

Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore

(2010) Christopher C. T. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection

(2010) Gerd Heusch et al.   BASIC RESEARCH IN CARDIOLOGY

Ethanolamine is a novel STAT-3 dependent cardioprotective agent

(2010) Roisin F. Kelly et al.   BASIC RESEARCH IN CARDIOLOGY

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Postconditioning and protection from reperfusion injury: where do we stand? * Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

(2010) M. Ovize et al.   CARDIOVASCULAR RESEARCH

Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice

(2010) Kenneth R. McGaffin et al.   CARDIOVASCULAR RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

(2010) Denise Hilfiker-Kleiner et al.   CIRCULATION

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

(2010) Masanori Obana et al.   CIRCULATION

Rebuilding the Damaged Heart

(2010) Nirat Beohar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New role of Notch-mediated signaling pathway in myocardial ischemic preconditioning

(2010) Yang Yang et al.   MEDICAL HYPOTHESES

Cardioprotection by ischemic postconditioning is abolished in depressed rats: role of Akt and signal transducer and activator of transcription-3

(2010) Chuanjun Zhuo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling

(2009) Matthias J. Merkel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ischemic postconditioning: experimental models and protocol algorithms

(2009) Andreas Skyschally et al.   BASIC RESEARCH IN CARDIOLOGY

STAT3 deletion sensitizes cells to oxidative stress

(2009) Seán P. Barry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy

(2009) Hong Yue et al.   CARDIOVASCULAR RESEARCH

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway

(2009) Lydia Lacerda et al.   CARDIOVASCULAR RESEARCH

The protective role of curcumin in cardiovascular diseases

(2009) Wanwarang Wongcharoen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Postinfarct Treatment With Oxytocin Improves Cardiac Function and Remodeling via Activating Cell-survival Signals and Angiogenesis

(2009) Hiroyuki Kobayashi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

(2009) Lin Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Mn-Superoxide Dismutase Activity and Neuroprotection by STAT3 in Mice after Cerebral Ischemia

(2009) J. E. Jung et al.   JOURNAL OF NEUROSCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion

(2009) Meijing Wang et al.   SURGERY

Regulating RISK: a role for JAK-STAT signaling in postconditioning?

(2008) Michael D. Goodman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success

(2008) Michael V. Cohen et al.   BASIC RESEARCH IN CARDIOLOGY

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

(2008) Britt N. Fuglesteg et al.   BASIC RESEARCH IN CARDIOLOGY

Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair

(2008) H. Kobayashi et al.   CARDIOVASCULAR RESEARCH

Mechanisms of Sex Differences in TNFR2-Mediated Cardioprotection

(2008) M. Wang et al.   CIRCULATION

Cardioprotection

(2008) Gerd Heusch et al.   CIRCULATION

Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury

(2008) Jarkko Piuhola et al.   CLINICAL SCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

The myocardial JAK/STAT pathway: From protection to failure

(2008) K BOENGLER et al.   PHARMACOLOGY & THERAPEUTICS

Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice

(2007) Kerstin Boengler et al.   CIRCULATION RESEARCH