STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

STAT3 can serve as a hit in the process of malignant transformation of primary cells

(2012) M Demaria et al.   CELL DEATH AND DIFFERENTIATION

Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity

(2012) John A. Jansen et al.   Circulation-Arrhythmia and Electrophysiology

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy

(2012) Veronika Nindl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

(2012) Annalisa Camporeale   Frontiers in Bioscience-Landmark

Complement regulation of T cell immunity

(2012) Wing-hong Kwan et al.   IMMUNOLOGIC RESEARCH

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis

(2011) Tomomi Yamashita et al.   CARDIOVASCULAR RESEARCH

Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias

(2011) Toshitaka Yajima et al.   CIRCULATION

The management of myocarditis

(2011) H.-P. Schultheiss et al.   EUROPEAN HEART JOURNAL

Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy

(2011) Michel Noutsias et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Transcription Factor STAT3 Is Required for T Helper 2 Cell Development

(2011) Gretta L. Stritesky et al.   IMMUNITY

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

(2010) Xiaolei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

(2010) Denise Hilfiker-Kleiner et al.   CIRCULATION

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

(2010) G. Christian Baldeviano et al.   CIRCULATION RESEARCH

Myeloid Differentiation Factor-88/Interleukin-1 Signaling Controls Cardiac Fibrosis and Heart Failure Progression in Inflammatory Dilated Cardiomyopathy

(2009) Przemyslaw Blyszczuk et al.   CIRCULATION RESEARCH

Myocarditis: Infection Versus Autoimmunity

(2009) Noel R. Rose   JOURNAL OF CLINICAL IMMUNOLOGY

Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity

(2008) Melvin D. Daniels et al.   AUTOIMMUNITY