An overview of molecular hybrids in drug discovery

Protein–Gold Hybrid Nanocubes for Cell Imaging and Drug Delivery

(2015) Han Ding et al.   ACS Applied Materials & Interfaces

Design, Synthesis andIn VitroAntiproliferative Activity of Novel Isatin-Quinazoline Hybrids

(2015) Mohamed Fares et al.   ARCHIV DER PHARMAZIE

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities

(2015) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemotherapy of leishmaniasis part XIII: Design and synthesis of novel heteroretinoid-bisbenzylidine ketone hybrids as antileishmanial agents

(2015) Avinash Tiwari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents

(2015) Li-Ying Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNA-binding affinity and anticancer activity of β-carboline–chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis

(2015) Nagula Shankaraiah et al.   BIOORGANIC CHEMISTRY

Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives

(2015) Deepti Pandita et al.   DRUG DISCOVERY TODAY

New heterocyclic hybrids of pyrazole and its bioisosteres: Design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents

(2015) Adnan A. Bekhit et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents

(2015) Wenbo Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design, synthesis and anti-proliferative evaluation of novel 1,4-benzoxazine-[1,2,3]triazole hybrids

(2015) Rajitha Bollu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents

(2015) Jun Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel hybrid DHPM-fatty acids: Synthesis and activity against glioma cell growth in vitro

(2015) Tamara G.M. Treptow et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies

(2015) Muhammad Taha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors

(2015) Xuan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Antitumor Carbazole-Amonafide Structural Hybrids

(2015) Alex Rozovsky et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents

(2015) Yiqiang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Novel ACK1/TNK2 Inhibitors Using a Fragment-Based Approach

(2015) Harshani R. Lawrence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents

(2015) Li-Ying Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

(2015) Li-Jun Wang et al.   Marine Drugs

C5-curcuminoid-4-aminoquinoline based molecular hybrids: design, synthesis and mechanistic investigation of anticancer activity

(2015) Shamseer Kulangara Kandi et al.   NEW JOURNAL OF CHEMISTRY

Design, synthesis, and biological and docking studies of novel epipodophyllotoxin–chalcone hybrids as potential anticancer agents

(2015) Abid Hussain Banday et al.   MedChemComm

Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

(2014) Ankita Rathore et al.   ARCHIV DER PHARMAZIE

Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

(2014) Arun A. Yadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and molecular modeling of biquinoline–pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors

(2014) Chetan B. Sangani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multisubstituted indole–acrylonitrile hybrids as potential cytotoxic agents

(2014) Shaoyong Ke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological effects of new hybrid compounds composed of benzylguanidines and the alkylating group of busulfan on neuroblastoma cells

(2014) Thomas Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors

(2014) S.G. Alegaon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Butyl-4-chloroimidazole based substituted piperazine-thiosemicarbazone hybrids as potent inhibitors of Mycobacterium tuberculosis

(2014) Anvesh Jallapally et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety

(2014) Kai Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytotoxicity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with one amino side chain

(2014) Guanhai Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids

(2014) Nagula Shankaraiah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytotoxicity and DNA binding property of triphenylethylene–coumarin hybrids with two amino side chains

(2014) Lian Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in Vitro Biological Evaluation of Hybrids from Tetrahydro-β-carboline and Hydroxylcinnamic Acid as Antitumor Carcinoma Agents

(2014) Ying Lin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Cyclometalated Ir(iii) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

(2014) Rui-Rong Ye et al.   CHEMICAL COMMUNICATIONS

Phase I, Dose-Escalation Study of the Targeted Cytotoxic LHRH Analog AEZS-108 in Patients with Castration- and Taxane-Resistant Prostate Cancer

(2014) S. V. Liu et al.   CLINICAL CANCER RESEARCH

Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents

(2014) Li-Ying Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin

(2014) Sheng-Feng Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity

(2014) Concepción Vilanova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents

(2014) Koneni V. Sashidhara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole–quinoline hybrids against cancer and primary endothelial cells

(2014) Kuldeep Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimycobacterial evaluation of 1-(4-(2-substitutedthiazol-4-yl)phenethyl)-4-(3-(4-substitutedpiperazin-1-yl)alkyl)piperazine hybrid analogues

(2014) Hunsur Nagendra Nagesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents

(2014) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells

(2014) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and molecular modeling of pyrazole–quinoline–pyridine hybrids as a new class of antimicrobial and anticancer agents

(2014) Chetan B. Sangani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarin derivatives: an updated patent review (2012 – 2014)

(2014) Anna-Maria Katsori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

(2014) Qi-Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin

(2014) Concepción Vilanova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hybrid pharmacophore-based drug design, synthesis, and antiproliferative activity of 1,4-dihydropyridines-linked alkylating anticancer agents

(2014) Rajesh K. Singh et al.   MEDICINAL CHEMISTRY RESEARCH

A review on pharmacophoric designs of antiproliferative agents

(2014) Anil Rana et al.   MEDICINAL CHEMISTRY RESEARCH

Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach

(2014) Mingfeng Shao et al.   MOLECULAR DIVERSITY

Hybrid Curcumin Compounds: A New Strategy for Cancer Treatment

(2014) Marie-Hélène Teiten et al.   MOLECULES

QSAR-Based Models for Designing Quinazoline/Imidazothiazoles/Pyrazolopyrimidines Based Inhibitors against Wild and Mutant EGFR

(2014) Jagat Singh Chauhan et al.   PLoS One

Discovery of novel steroidal pyran–oxindole hybrids as cytotoxic agents

(2014) Bin Yu et al.   STEROIDS

Design, synthesis and molecular docking of novel bipyrazolyl thiazolone scaffold as a new class of antibacterial agents

(2014) Piyush N. Kalaria et al.   MedChemComm

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

(2013) Chandraiah Lagisetti et al.   ACS Chemical Biology

Tumour vasculature targeting agents in hybrid/conjugate drugs

(2013) E. M. Prokopiou et al.   ANGIOGENESIS

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

(2013) Gabriele Montanaro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

(2013) Xuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

(2013) Xuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents

(2013) Imran Ahmad et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anti-parasitic activity of a novel quinolinone–chalcone series

(2013) Marina Roussaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and anti-tumor activities of novel triphenylethylene–coumarin hybrids, and their interactions with Ct-DNA

(2013) Hua Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

(2013) Xiaohua Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities

(2013) Palwinder Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce Pro-apoptosis in Human Hormone-independent Prostate Cancer Cell Lines

(2013) Dominique Brossard et al.   Chemical Biology & Drug Design

Rationally Designed Multitarget Anti-HIV Agents

(2013) P. Zhan et al.   CURRENT MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

(2013) Xue-Quan Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarin chalcone fibrates: A new structural class of lipid lowering agents

(2013) Koneni V. Sashidhara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The development of bis(hydroxymethyl)pyrrole analogs as bifunctional DNA cross-linking agents and their chemotherapeutic potential

(2013) Tsann-Long Su et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole–dithiocarbamate–urea hybrids

(2013) Ying-Chao Duan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents

(2013) Ying-Chao Duan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

(2013) Rahul P. Modh et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Fimbrolide–Nitric Oxide Donor Hybrids as Antimicrobial Agents

(2013) Samuel K. Kutty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins

(2013) Yuta Tanaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities

(2013) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability

(2013) Junjie Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Steroid-linked nitrogen mustards as potential anticancer therapeutics: A review

(2013) Pijus Saha et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hybrid anticancer 1,2-diazine derivatives with multiple mechanism of action. Part 3 [4,5]

(2013) Vasilichia Antoci et al.   MEDICAL HYPOTHESES

Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

(2013) Bhaveshkumar D. Dhorajiya et al.   MEDICINAL CHEMISTRY RESEARCH

Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

(2013) Xin Zhai et al.   MOLECULES

The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors

(2013) Xuan Zhang et al.   MOLECULES

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma

(2013) Kai Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cell-targeted cytotoxics: a new generation of cytotoxic agents for cancer treatment

(2013) Christian Bailly   PHYTOCHEMISTRY REVIEWS

Functional polypeptide and hybrid materials: Precision synthesis via α-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

(2013) Chao Deng et al.   PROGRESS IN POLYMER SCIENCE

DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers

(2012) Jimmy Suryadi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Using a Build-and-Click Approach for Producing Structural and Functional Diversity in DNA-Targeted Hybrid Anticancer Agents

(2012) Song Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

(2011) Qi-Yin Chen et al.   ACS Medicinal Chemistry Letters